Preliminary study on modelling, fabrication by photo-chemical etching and in vivo testing of biodegradable magnesium AZ31 stents

作     者：Bala Subramanya Pavan Kumar Kandala Guangqi Zhang Capucine LCorriveau Mark Paquin Madeleine Chagnon Dana Begun Vesselin Shanov 

作者机构：Department of Mechanical and Materials EngineeringUniversity of CincinnatiOH45221USA Department of Chemical and Environmental EngineeringUniversity of CincinnatiOH45221USA Charles River Laboratories Montreal ULCBoisbriandQuebecJ7H 1N8Canada Medical Products Market ConsultingIncIndianapolisIN46202USA Waygate TechnologiesBaker HughesCincinnatiOH45241USA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2021年第6卷第6期

页      面：1663-1675页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：The authors would like to acknowledge the financial support provided by the NSF ERC for Revolutionizing Biomaterials through grant EEC-EEC-0812348 We would like to thank Dr.Sarah Pixley for helping us with the sample fixation for the micro-CT analysis and for proofreading the manuscript The help of Dr.Melodie Fickenscher with the SEM imaging and EDS analysis of the corroded stents is appreciated 

主　　题：Magnesium alloy FEA modelling Stents Photo-chemically etching Micro-CT Histology 

摘      要：Magnesium metal(Mg)is a promising material for stent applications due to its biocompatibility and ability to be resorbed by the *** of stents by laser cutting has become an industry *** alternative approach uses photo-chemical etching to transfer a pattern of the stent onto a Mg *** this study,we present three stages of creating and validating a stent prototype,which includes design and simulation using finite element analysis(FEA),followed by fabrication based on AZ31 alloy and,finally,in vivo testing in peripheral arteries of domestic *** to the preliminary character of this study,only six stents were implanted in two domestic farm pigs weighing 25-28 kg and they were evaluated after 28 days,with an interim follow-up on day *** left and right superficial femoral,the left iliac,and the right renal artery were selected for this *** diameters of the stented artery segments were evaluated at the time of implantation,on day 14 and then,finally,on day 28,by quantitative vessel analysis(QVA)using fluoroscopic *** Coherence Tomography(OCT)imaging displayed some malposition,breaks,stacking,and protrusion into the lumen at the proximal,distal,and mid-sections of the stented *** stents degraded with time,but simultaneously became embedded in the *** 28 days,the animals were euthanized,and explanted vessels were fixed for micro-CT imaging and histology ***-CT imaging revealed stent morphological and volumetric changes due to the in-body *** in vivo corrosion rate of 0.75 mm/year was obtained by the CT *** histology suggested no-life threatening effects,although moderate injury,inflammation,and endothelialization scores were observed.