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Current application of neurofilaments in amyotrophic lateral sclerosis and future perspectives

Neural Regeneration Research 2021年第10期16卷 1985-1991页

作者： Yuri Matteo Falzone Tommaso Russo Teuta Domi Laura Pozzi Angelo Quattrini Massimo Filippi Nilo Riva Neuropathology Unit Institute of Experimental NeurologyDivision of NeuroscienceSan Raffaele Scientific InstituteMilanItaly Neurology and Neurorehabilitation Unit IRCCS SanRaffaele Scientific InstituteMilanItaly Neurophysiology Unit IRCCS San Raffaele Scientific InstituteMilanItaly Neuroimaging Research Unit Institute of Experimental NeurologyDivision of NeuroscienceIRCCS San Raffaele Scientific InstituteMilanItaly Vita-Salute San Rafaele University MilanItaly

Motor neuron disease includes a heterogeneous group of relentless progressive neurological disorders defined and characterized by the degeneration of motor *** lateral sclerosis is the most common and aggressive form of motor neuron disease with no effective treatment so ***,diagnostic and prognostic biomarkers are lacking in clinical *** are fundamental structural components of the axons and neurofilament light chain and phosphorylated neurofilament heavy chain can be measured in both cerebrospinal fluid and *** light chain and phosphorylated neurofilament heavy chain levels are elevated in amyotrophic lateral sclerosis,reflecting the extensive damage of motor neurons and ***,neurofilaments are now increasingly recognized as the most promising candidate biomarker in amyotrophic lateral *** potential usefulness of neurofilaments regards various aspects,including diagnosis,prognosis,patient stratification in clinical trials and evaluation of treatment *** this review paper,we review the body of literature about neurofilaments measurement in amyotrophic lateral *** also discuss the open issues concerning the use of neurofilaments clinical practice,as no overall guideline exists to date;finally,we address the most recent evidence and future perspectives.

关键词： amyotrophic lateral sclerosis biomarkers motor neuron disease neurofilament light chain phosphorylated neurofilament heavy chain

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Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy:Contribution of neurochemical markers to early diagnosis

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Infectious Medicine 2022年第2期1卷 140-142页

作者： Souheil Zayet Hajer Zahra Nabil Belfeki Timothée Klopfenstein Beate Hagenkötter Infectious Diseases Department Nord Franche-ComtéHospitalFrance Diabetology Department Nord Franche-ComtéHospitalFrance Internal Medicine Department Groupe Hospitalier Sud Ile de FranceMelunFrance Neurology Department Nord Franche-ComtéHospitalFrance

Background:The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in late *** recently,there have been sporadic case reports on devel-opment of Miller-Fisher Syndrome,a rare variant of Guillain-BarréSyndrome in COVID-19 *** report:We reported herein the case of a French young women presenting with ophtalmoplegia,cerebellar ataxia,and universal areflexia following a bariatric surgery(sleeve gastrectomy).A concomitant COVID-19 diagnosis was retained based on microbiological *** patient was successfully treated after high-dose intravenous thiamine,but areflexia *** COVID-19 related Miller-Fisher Syndrome was established on physical examination and confirmed by pathologic neurophysiological findings and elevated level of phosphorylated neurofilament heavy chain protein in cerebrospinal fluid ***:Guillain-BarréSyndrome and its variants after SARS-CoV-2 infection are extremely *** mea-surement of phosphorylated neurofilament heavy chain protein should be considered as an easy tool to detect an early affection of the peripheral nervous system.

关键词： COVID-19 Miller-fisher syndrome Wernicke encephalopathy Bariatric surgery phosphorylated neurofilament heavy chain Protein

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