Atypical miller-fisher syndrome after COVID-19 and sleeve gastrectomy:Contribution of neurochemical markers to early diagnosis

作     者：Souheil Zayet Hajer Zahra Nabil Belfeki Timothée Klopfenstein Beate Hagenkötter Souheil Zayet;Hajer Zahra;Nabil Belfeki;Timothée Klopfenstein;Beate Hagenk?tter

作者机构：Infectious Diseases DepartmentNord Franche-ComtéHospitalFrance Diabetology DepartmentNord Franche-ComtéHospitalFrance Internal Medicine DepartmentGroupe Hospitalier Sud Ile de FranceMelunFrance Neurology DepartmentNord Franche-ComtéHospitalFrance 

出 版 物：《Infectious Medicine》 (感染医学（英文）)

年 卷 期：2022年第1卷第2期

页      面：140-142页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：COVID-19 Miller-fisher syndrome Wernicke encephalopathy Bariatric surgery Phosphorylated neurofilament heavy chain Protein 

摘      要：Background:The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),began in late *** recently,there have been sporadic case reports on devel-opment of Miller-Fisher Syndrome,a rare variant of Guillain-BarréSyndrome in COVID-19 *** report:We reported herein the case of a French young women presenting with ophtalmoplegia,cerebellar ataxia,and universal areflexia following a bariatric surgery(sleeve gastrectomy).A concomitant COVID-19 diagnosis was retained based on microbiological *** patient was successfully treated after high-dose intravenous thiamine,but areflexia *** COVID-19 related Miller-Fisher Syndrome was established on physical examination and confirmed by pathologic neurophysiological findings and elevated level of phosphorylated neurofilament heavy chain protein in cerebrospinal fluid ***:Guillain-BarréSyndrome and its variants after SARS-CoV-2 infection are extremely *** mea-surement of phosphorylated neurofilament heavy chain protein should be considered as an easy tool to detect an early affection of the peripheral nervous system.