检索结果-南通市图书馆

Pharmacological and Immunological Aspects of phage therapy

Infectious Microbes & Diseases 2019年第2期1卷 34-42页

作者： Prasanth Manohar Ashok.J.Tamhankar Sebastian Leptihn Nachimuthu Ramesh Antibiotic Resistance and phage therapy Laboratory Department of Biomedical SciencesSchool of Biosciences and TechnologyVellore Institute of Technology(VIT)Vellore 632014Tamil NaduIndia Global Health Health Systems and Policy:Medicines-focusing AntibioticsDepartment of Public Health SciencesKarolinska InstitutetStockholmSweden Indian Initiative for Management of Antibiotic resistance Department of Environmental MedicineRuxmaniben Deepchand Gardi Medical CollegeUjjainIndia Zhejiang University School of Medicine Zhejiang University-Edinburgh University(ZJU-UoE)InstituteInternational CampusZhejiang UniversityHainingZhejiang 314400China Department of Infectious Diseases Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouChina.

Bacteriophages,or viruses of microbes,when used as a medical strategy,might be able to solve the current crisis mankind faces with the increasing number of pathogens being antibiotic-resistant,where chemical drugs seized to show any therapeutic *** socalled phage therapy may be one of the most promising alternatives to treat infections caused by antibiotic-resistant bacteria,which are killed after infection by a *** phages that destroy the host by lysis are chosen for therapy,many pharmacological and immunological aspects of phages as medicines have not been established so *** immune system plays an important role in a process called phage acceptance where both,innate and adaptive immune responses of the host are ***,not only medical aspects but also social ones such as lacking public awareness or acceptance,and lack of structured regulatory guidelines are challenges that have to be addressed in the near future to establish phage therapy as a reliable and safe alternative for the treatment of *** review focuses on the unique pharmacological and immunological aspects of phages used in therapy.

关键词： phage therapy phage immune response phage stability bacteriophages phage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defense and anti-defense mechanisms of bacteria and bacteriophages

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 181-196页

作者： Xiaoqing WANG Sebastian LEPTIHN School of Medicine Lishui UniversityLishui 323000China University of Edinburgh Medical School Biomedical SciencesCollege of Medicine&Veterinary MedicineThe University of EdinburghEdinburgh EH89JZUK HMU Health and Medical University Am Anger 64/73-99084 ErfurtGermany

In the post-antibiotic era,the overuse of antimicrobials has led to a massive increase in antimicrobial resistance,leaving medical doctors few or no treatment options to fight infections caused by *** use of bacteriophages is a promising alternative to treat infections,supplementing or possibly even replacing *** phages for therapy is possible,since these bacterial viruses can kill bacteria specifically,causing no harm to the normal ***,bacteria have developed a multitude of sophisticated and complex ways to resist infection by phages,including abortive infection and the clustered regularly interspersed short palindromic repeats(CRISPR)/CRISPR-associated(Cas)*** also can evolve and acquire new anti-defense strategies to continue *** in-depth exploration of both defense and anti-defense mechanisms would contribute to optimizing phage therapy,while we would also gain novel insights into the microbial *** this paper,we summarize recent research on bacterial phage resistance and phage anti-defense mechanisms,as well as collaborative win-win systems involving both virus and host.

关键词： Bacteriophage phage resistance Abortive infection phage therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A review on re-emerging bacteriophage therapy in the era of XDR

引用

生物细胞(英文) 2023年第9期47卷 1915-1930页

作者： POOJA BHADORIYA RICHA SHARMA REKHA MEHROTRA SIMRAN KAUR ISHA SRIVASTAVA MUKUL JAIN PRASHANT KAUSHIK Department of Microbiology Shaheed Rajguru College of Applied Sciences for WomenUniversity of DelhiVasundhara EnclaveNew Delhi110096India Lab-209 Cell&Developmental biology labCenter of Research for DevelopmentParul UniversityVadodara391760GujaratIndia Instituto de Conservacióny Mejora de la Agrodiversidad Valenciana Universitat Politècnica de ValènciaValencia46022Spain

In the present medicine world antibiotic resistance is one of the key threats to universal health *** continue to work hard to combat this global health *** therapy,an age-old practice during the early twentieth century,was outshined by the discovery of *** the advent of widespread antibiotic resistance,phage therapy has again redeemed itself as a potential alternative owing to its adeptness to target bacteria *** side effects,the ability to migrate to different body organs,a distinct mode of action,and proliferation at the infection site,make phages a profitable candidate to replace conventional *** progressive outcome of numerous in vitro studies and case reports has validated the clinical efficacy of phage *** bright perspective of using phages to treat bacterial infections has fueled enormous medical research to exploit their potential as *** gaps in the information about phages and the lack of consent for clinical trials is major hurdle for consideration of phage *** phage therapy as a reality in medicine requires a coordinated effort from different *** this review,we aim to emphasize the importance of phage therapy in modern *** review explains their historical journey,basic phage biology,cross-talk with the host immunity,obstacles with phage therapy,and their possible *** data on the various significant clinical trials of phage therapy has been *** evaluated the efficacy of antibiotics and phage therapy in part and in combination,along with recent progress and future perspectives of phage therapy.

关键词： Bacteriophages Antibiotic resistance phage biology phage therapy phage therapy clinical trials phage therapy in India

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Characterization of bacteriophage BUCT631 lytic for K1 Klebsiella pneumoniae and its therapeutic efficacy in Galleria mellonella larvae

引用

Virologica Sinica 2023年第5期38卷 801-812页

作者： Pengjun Han Mingfang Pu Yahao Li Huahao Fan Yigang Tong College of Life Science and Technology Beijing University of Chemical TechnologyBeijing100029China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijing100029China

Severe infections caused by multidrug-resistant Klebsiella pneumoniae(***)highlight the need for new therapeutics with activity against this *** therapy is an alternative treatment approach for multidrug-resistant *** ***,we report a novel bacteriophage(phage)BUCT631 that can specifically lyse capsule-type K1 *** characterization revealed that phage BUCT631 could rapidly adsorb to the surface of *** and form an obvious halo ring,and it had relatively favorable thermal stability(4–50C)and pH tolerance(pH?4–12).In addition,the optimal multiplicity of infection(MOI)of phage BUCT631 was 0.01,and the burst size was approximately 303 PFU/*** analysis showed that phage BUCT631 has double-stranded DNA(total length of 44,812 bp)with a G t C content of 54.1%,and the genome contains 57 open reading frames(ORFs)and no virulence or antibiotic resistance related *** on phylogenetic analysis,phage BUCT631 could be assigned to a new species in the genus Drulisvirus of the subfamily *** addition,phage BUCT631 could quickly inhibit the growth of *** within 2 h in vitro and significantly elevated the survival rate of *** infected Galleria mellonella larvae from 10%to 90%in *** studies suggest that phage BUCT631 has promising potential for development as a safe alternative for control and treatment of multidrug-resistant *** infection.

关键词： Bacteriophage BUCT631 Klebsiella pneumoniae Genomic analysis phage therapy Galleria mellonella

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

phage engineering： how advances in molecular biology and synthetic biology are being utilized to enhance the therapeutic potential of bacteriophages

引用

Frontiers of Electrical and Electronic Engineering in China 2017年第1期5卷 42-54页

作者： Russell Brown Andreas Lengeling Baojun Wang School of Biological Sciences University of Edinburgh Edinburgh EH9 3FF UK Centre for Synthetic and Systems Biology University of Edinburgh Edinburgh EH9 3FF UK Infection and Immunity Division The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh Edinburgh EH25 9RG UK

Background： The therapeutic potential of bacteriophages has been debated since their first isolation and characterisation in the early 20th century. However, a lack of consistency in application and observed efficacy during their early use meant that upon the discovery of antibiotic compounds research in the field of phage therapy quickly slowed. The rise of antibiotic resistance in bacteria and improvements in our abilities to modify and manipulate DNA, especially in the context of small viral genomes, has led to a recent resurgence of interest in utilising phage as antimicrobial therapeutics. Results： In this article a number of results from the literature that have aimed to address key issues regarding the utility and efficacy of phage as antimicrobial therapeutics utilising molecular biology and synthetic biology approaches will be introduced and discussed, giving a general view of the recent progress in the field. Conclusions： Advances in molecular biology and synthetic biology have enabled rapid progress in the field of phage engineering, with this article highlighting a number of promising strategies developed to optimise phages for the treatment of bacterial disease. Whilst many of the same issues that have historically limited the use of phages as therapeutics still exist, these modifications, or combinations thereof, may form a basis upon which future advances can be built. A focus on rigorous in vivo testing and investment in clinical trials for promising candidate phages may be required for the field to truly mature, but there is renewed hope that the potential benefits of phage therapy may finally be realised.

关键词： bacteriophage phage therapy phage engineering synthetic biology

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bacteriophages as antimicrobial agents against major pathogens in swine： a review

引用

Journal of Animal Science and Biotechnology 2016年第1期7卷 50-56页

作者： Jiancheng Zhang Zhen Li Zhenhui Cao Lili Wang Xiaoyu Li Shuying Li Yongping Xu School of Life Science and Biotechnology Dalian University of TechnologyDalian 116024China Ministry of Education Center for Food Safety of Animal Origin Dalian 116600China Faculty of Animal Science and Technology Yunnan Agricultural UniversityKunming 650201China Dalian SEM Bio-Engineering Technology Co.Ltd. Dalian 116620China

In recent years, the development of antibiotic resistant bacteria has become a global concern which has prompted research into the development of alternative disease control strategies for the swine industry. Bacteriophages （viruses that infect bacteria） offer the prospect of a sustainable alternative approach against bacterial pathogens with the flexibility of being applied therapeutically or for biological control purposes. This paper reviews the use of phages as an antimicrobial strategy for controlling critical pathogens including Salmonella and Eschefich[a coli with an emphasis on the application of phages for improving performance and nutrient digestibility in swine operations as well as in controlling zoonotic human diseases by reducing the bacterial load spread from pork products to humans through the meat,

关键词： Antibiotic resistance Bacteriophage Food safety phage therapy Swine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：