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Current trends in perioperative treatment of resectable gastric cancer

World Journal of Gastrointestinal Surgery 2023年第3期15卷 323-337页

作者： İbrahim Yıldız Leyla Özer Elif Şenocak Taşçı İbrahim Vedat Bayoglu Erman Aytac Department of Medical Oncology Acıbadem MAA Universityİstanbul 34567Turkey Department of Medical Oncology Acıbadem Universityİstanbul 34567Turkey Department of Medical Oncology Marmara Universityİstanbul 12345Turkey Department of Surgery Acibadem University School of MedicineIstanbul 34567Turkey

In the last few decades,the treatment strategy for locally advanced resectable gastric cancer(GC)has shifted to a multimodal approach,which potentially decreases recurrence risk and improves survival *** therapy leads to downstaging,increased curative resection rates,and prolonged disease-free and overall survival,by preventing micrometastases in patients with resectable *** of neoadjuvant therapy provides information about tumor biology and in vivo sensitivity.A consensus regarding the therapeutic approach for non-metastatic GC does not exist,and many clinical trials aim to clarify this *** in precision medicine and the role of immunotherapy have been the focus of research in GC ***,the current status and possible future developments of perioperative therapy for locally advanced resectable GC are reviewed,based on the most recent randomized clinical trials.

关键词： perioperative treatment Immunotherapy Neoadjuvant Chemotherapy Gastric cancer Adjuvant

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perioperative treatment of liver transplantation

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Discussion of Clinical Cases 2014年第1期1卷 12-18页

作者： Shengbin Zhang Rui Liu Shipeng Song Weiqing Wang Jin Zhao Xiaoshi Dong The Third Affiliated Hospital of Inner Mongolia Medical University HohhotChina

A case of liver transplantation in the department of general surgery of the third affiliated hospital of Inner Mongolia medical school was collected and analyzed on the basis of diagnosis,physical examination and *** transplantation was very complicated,accompanied by various postoperative *** this paper aims to share experience of perioperative management of liver transplantation among physicians.

关键词： Liver transplantation perioperative treatment perioperative management

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perioperative treatment options in resectable pancreatic cancer-how to improve long-term survival

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World Journal of Gastrointestinal Oncology 2016年第3期8卷 248-257页

作者： Marianne Sinn Marcus Bahra Timm Denecke Sue Travis Uwe Pelzer Hanno Riess Department of Medical Oncology and Haematology Charité-Universitatsmedizin Berlin Department of General Visceral and Transplantation SurgeryCharité-Universitatsmedizin Berlin Institute of Radiology Charité-Universitatsmedizin Berlin

Surgery remains the only chance of cure for pancreatic cancer, but only 15%-25% of patients present with resectable disease at the time of primary diagnosis. Important goals in clinical research must therefore be to allow early detection with suitable diagnostic procedures, to further broaden operation techniques and to determine the most effective perioperative treatment of either chemotherapy and/or radiation therapy. More extensive operations involving extended pancreatectomy, portal vein resection and pancreatic resection in resectable pancreatic cancer with limited liver metastasis, performed in specialized centers seem to be the surgical procedures with a possible impact on survival. After many years of stagnation in pharmacological clinical research on advanced pancreatic ductal adenocarcinomas(PDAC)- since the approval of gemcitabine in 1997- more effective cytotoxic substances(nab-paclitaxel) and combinations(FOLFIRINOX) are now available for perioperative treatment. Additionally, therapies with a broader mechanism of action are emerging(stroma depletion, immunotherapy, antiinflammation), raising hopes for more effective adjuvant and neoadjuvant treatment concepts, especially in the context of "borderline resectability". Only multidisciplinary approaches including radiology, surgery, medical and radiation oncology as the backbones of the treatment of potentially resectable PDAC may be able to further improve the rate of cure in the future.

关键词： Pancreatic cancer perioperative treatment perioperative radiology Chemotherapy

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Efficacy and safety of perioperative therapy for locally resectable gastric cancer:A network meta-analysis of randomized clinical trials

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1046-1058页

作者： Zi-Yu Kuang Qian-Hui Sun Lu-Chang Cao Xin-Yi Ma Jia-Xi Wang Ke-Xin Liu Jie Li Graduate College Beijing University of Traditional Chinese MedicineBeijing 100029China Oncology Department Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

BACKGROUND Gastric cancer(GC)is the fifth most commonly diagnosed malignancy worldwide,with over 1 million new cases per year,and the third leading cause of cancer-related *** To determine the optimal perioperative treatment regimen for patients with locally resectable *** A comprehensive literature search was conducted,focusing on phase II/III randomized controlled trials(RCTs)assessing perioperative chemotherapy and chemoradiotherapy in treating locally resectable *** R0 resection rate,overall survival(OS),disease-free survival(DFS),and incidence of grade 3 or higher nonsurgical severe adverse events(SAEs)associated with various perioperative regimens were analyzed.A Bayesian network meta-analysis was performed to compare treatment regimens and rank their *** Thirty RCTs involving 8346 patients were included in this *** XELOX plus neoadjuvant radiotherapy and neoadjuvant CF were found to significantly improve the R0 resection rate compared with surgery alone,and the former had the highest probability of being the most effective option in this *** plus adjuvant FLOT was associated with the highest probability of being the best regimen for improving *** to limited data,no definitive ranking could be determined for *** nonsurgical SAEs,FLO has emerged as the safest treatment *** This study provides valuable insights for clinicians when selecting perioperative treatment regimens for patients with locally resectable *** studies are required to validate these findings.

关键词： Gastric cancer perioperative treatment Network meta-analysis Efficacy and safety

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