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World Journal of Gastroenterology 2017年第21期23卷 3907-3914页

作者： Jun Yao Lu-Lin Zhang Xu-Mei Huang Wen-Yao Li She-Gan Gao Henan Key Laboratory of Cancer Epigenetics Cancer Institute the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology Simmons Comprehensive Cancer Center UT Southwestern Medical Center

AIM To detect the expression of pleiotrophin(PTN) and N-syndecan in pancreatic cancer and analyze their association with tumor progression and perineural invasion(PNI).METHODS An orthotopic mouse model of pancreatic cancer was created by injecting tumor cells subcapsularly in a root region of the pancreas beneath the spleen. Pancreatic cancer tissues were taken from 36 mice that survived for more than 90 d. PTN and N-syndecan proteins were detected by immunohistochemistry and analyzed for their correlation with pathological features, PNI, and *** The expression rates of PTN and N-syndecan proteinswere 66.7% and 61.1%, respectively, in cancer tissue. PTN and N-syndecan expression was associated with PNI(P = 0.019 and P = 0.032, respectively). High PTN expression was closely associated with large bloody ascites(P = 0.009), liver metastasis(P = 0.035), and decreased survival time(P = 0.022). N-syndecan expression was significantly associated with tumor size(P = 0.025), but not with survival time(P = 0.539). CONCLUSION High PTN and N-syndecan expression was closely associated with metastasis and poor prognosis, suggesting that they may promote tumor progression and PNI in the orthotopic mouse model of pancreatic cancer.

关键词： Pleiotrophin N-syndecan Pancreatic cancer perineural invasion

Preoperative prediction of lymphovascular and perineural invasion in gastric cancer using spectral computed tomography imaging and machine learning

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World Journal of Gastroenterology 2024年第6期30卷 542-555页

作者： Hui-Ting Ge Jian-Wu Chen Li-Li Wang Tian-Xiu Zou Bin Zheng Yuan-Fen Liu Yun-Jing Xue Wei-Wen Lin Department of Radiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Digestive Hematological and Breast MalignanciesClinical Research Center for Radiology and Radiotherapy of Fujian ProvinceFuzhou 350001Fujian ProvinceChina Department of Radiation Oncology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Department of Diagnostic Radiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina School of Electrical and Computer Engineering University of OklahomaOklahomaOK 73019United States

BACKGROUND Lymphovascular invasion(LVI)and perineural invasion(PNI)are important prognostic factors for gastric cancer(GC)that indicate an increased risk of metastasis and poor *** preoperative prediction of LVI/PNI status could help clinicians identify high-risk patients and guide treatment ***,prior models using conventional computed tomography(CT)images to predict LVI or PNI separately have had limited *** CT provides quantitative enhancement parameters that may better capture tumor *** hypothesized that a predictive model combining clinical and spectral CT parameters would accurately preoperatively predict LVI/PNI status in GC *** To develop and test a machine learning model that fuses spectral CT parameters and clinical indicators to predict LVI/PNI status *** This study used a retrospective dataset involving 257 GC patients(training cohort,n=172;validation cohort,n=85).First,several clinical indicators,including serum tumor markers,CT-TN stages and CT-detected extramural vein invasion(CT-EMVI),were extracted,as were quantitative spectral CT parameters from the delineated tumor ***,a two-step feature selection approach using correlation-based methods and information gain ranking inside a 10-fold cross-validation loop was utilized to select informative clinical and spectral CT parameters.A logistic regression(LR)-based nomogram model was subsequently constructed to predict LVI/PNI status,and its performance was evaluated using the area under the receiver operating characteristic curve(AUC).RESULTS In both the training and validation cohorts,CT T3-4 stage,CT-N positive status,and CT-EMVI positive status are more prevalent in the LVI/PNI-positive group and these differences are statistically significant(P<0.05).LR analysis of the training group showed preoperative CT-T stage,CT-EMVI,single-energy CT values of 70 keV of venous phase(VP-70 keV),and the ratio of standardized iodine co

关键词： Spectral computed tomography Gastric cancer Lymphovascular invasion perineural invasion

Prediction of the lymphatic,microvascular,and perineural invasion of pancreatic neuroendocrine tumors using preoperative magnetic resonance imaging

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2809-2819页

作者： Yu-Liang Liu Hai-Bin Zhu Mai-Lin Chen Wei Sun Xiao-Ting Li Ying-Shi Sun Department of Radiology Peking University Cancer Hospital and InstituteBeijing 100142China Department of Pathology Peking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND Significant correlation between lymphatic,microvascular,and perineural invasion(LMPI)and the prognosis of pancreatic neuroendocrine tumors(PENTs)was confirmed by previous *** was no previous study reported the relationship between magnetic resonance imaging(MRI)parameters and *** To determine the feasibility of using preoperative MRI of the pancreas to predict LMPI in patients with non-functioning PENTs(NFPNETs).METHODS A total of 61 patients with NFPNETs who underwent MRI scans and lymphadenectomy from May 2011 to June 2018 were included in this retrospective *** patients were divided into group 1(n=34,LMPI negative)and group 2(n=27,LMPI positive).The clinical characteristics and qualitative MRI features were *** order to predict LMPI status in NF-PNETs,a multivariate logistic regression model was *** performance was evaluated by calculating the receiver operator characteristic(ROC)curve with area under ROC,sensitivity,specificity,positive predictive value(PPV),negative predictive value(NPV)and *** There were significant differences in the lymph node metastasis stage,tumor grade,neuron-specific enolase levels,tumor margin,main pancreatic ductal dilatation,common bile duct dilatation,enhancement pattern,vascular and adjacent tissue involvement,synchronous liver metastases,the long axis of the largest lymph node,the short axis of the largest lymph node,number of the lymph nodes with short axis>5 or 10 mm,and tumor volume between two groups(P<0.05).Multivariate analysis showed that tumor margin(odds ratio=11.523,P<0.001)was a predictive factor for LMPI of *** area under the receiver value for the predictive performance of combined predictive factors was *** sensitivity,specificity,PPV,NPV and accuracy of the model were 48.1%(14/27),97.1%(33/34),97.1%(13/14),70.2%(33/47)and 0.754,*** Using preoperative MRI,ill-defined tumor margins can effectively predict LMPI in

关键词： Pancreatic neuroendocrine tumors Magnetic resonance imaging Lymphatic invasion Microvascular invasion perineural invasion

Preliminary study correlating CX3CL1/CX3CR1 expression with gastric carcinoma and gastric carcinoma perineural invasion

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World Journal of Gastroenterology 2014年第15期20卷 4428-4432页

作者： Cheng-Yu Lv Tao Zhou Wei Chen Xin-Dao Yin Jian-Hong Yao Yi-Fan Zhang Department of General Surgery Nanjing Hospital Affiliated to Nanjing Medical University

AIM: To study the relationship between the CX3CL1 chemokine, its receptor CX3CR1, and gastric carcinoma/gastric carcinoma perineural invasion (PNI).

关键词： Gastric carcinoma perineural invasion CX3CL1 CX3CR1

Muscarinic acetylcholine receptor M3 in proliferation and perineural invasion of cholangiocarcinoma cells

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 418-423页

作者： Yu-Jie Feng,Bing-Yuan Zhang,Ru-Yong Yao and Yun LuSecond Department of General Surgery and Central Laboratory of Molecular Biology,Affiliated Medical College Hospital,Qingdao University,Qingdao 266003,China [a] Second Department of General Surgery Affiliated Medical College Hospital Qingdao University Qingdao 266003 China [b] Second Department of General Surgery and Central Laboratory of Molecular Biology Affiliated Medical College Hospital Qingdao University Qingdao 266003 China

BACKGROUND:Cholangiocarcinoma,a type of malignant tumor,originates from epithelial cells of the bile *** invasion is common path for cholangiocarcinoma metastasis,and it is highly correlated with postoperative recurrence and poor *** has been reported that muscarinic acetylcholine receptor M3(mAChR M3) is widely expressed in digestive tract cancer,and may play an important role in the proliferation,differentiation,transformation and carcinogenesis of *** study was to explore the effect of mAChR M3 on the growth of cholangiocarcinoma cells in vitro and provide a new approach to the pathogenesis and treatment of ***:Streptavidin-biotin complex immunohistochemistry was carried out to assess the expression of mAChR M3 in surgical specimens of cholangiocarcinomas(40 cases) and normal bile duct tissues(9),as well as to investigate nerve *** cholangiocarcinoma cells were treated with different concentrations of selective M-receptor agonist pilocarpine and M-receptor blocker atropine sulfate to induce changes in cell *** experimental data were analyzed by the Chi-square ***:The strongly-positive expression rate of mAChR M3 was much higher in poorly-differentiated(69%,9/13) than in well-and moderately-differentiated cholangiocarcinomas(30%,8/27)(χ 2 =5.631,P<0.05).The strongly-positive mAChR M3 expression rate in hilar cholangiocarcinoma(50%,14/28) was higher than that in cholangiocarcinomas from the middle and lower common bile duct(25%,3/12)(χ 2 =2.148,P<0.05).Cholangiocarcinomas with distant metastasis had a stronglypositive expression rate(75%,9/12),which was much higher than those without distant metastasis(29%,8/28)(χ 2 =7.410,P<0.01).The absorbance value in the pilocarpine+atropine group was significantly higher than the corresponding value in the pilocarpine ***:The expression of mAChR M3 is influenced by the extent of differentiation,distant metastasis and the site

关键词： cholangiocarcinoma mAChR M3 immunohistochemistry perineural invasion proliferation

perineural invasion:a potential reason of hepatocellular carcinoma bone metastasis

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Continuous Low-dose-rate Irradiation of Iodine-125 Seeds Inhibiting perineural invasion in Pancreatic Cancer

2015年浙江省骨科学学术年会

作者： Xuanwei Wang Tong Shen Pengcheng Gu Fang Guo Xiangjin Lin

The nervous system plays an important role in the regulation of epithelial homeostasis and has also been postulated to play a role in *** invasion(PNI) is the only interaction between cancer cells and nerves studied to *** is a symbiotic relationship between cancer cells and nerves that result in growth advantage for *** potential association between HCC bone metastases and PNI is *** this study,we investigate the nerve density in HCC and paired bone metastases to reveal the potential association of HCC bone metastases and *** nerve density was evaluated by immunohistochemistry in formalin-fixed paraffin embedded(FFPE) hepatocellular carcinoma(HCC) and paired bone metastases tissues from 13 HCC patients with synchronous or metachronous bone metastases that underwent surgical *** specimens of HCC bone metastases tissues express higher perineural density than HCC tissues,pointing to a potential role of the PNI in bone metastases from *** is the first description of the potential association of PNI and HCC bone metastases.

关键词： Hepatocellular carcinoma bone metastasis perineural invasion nerve density

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Chinese Medical Journal 2016年第20期129卷 2460-2468页

作者： Zheng Lu Teng-Hui Dong Pei-Ren Si Wei Shen Yi-Liang Bi Min Min Xin Chen Yan Liu Liver Cirrhosis Diagnosis and Therapy Center 302 Hospital of People's Liberation ArmyBeijing 100039China Department of Gastroenterology and Hepatology 307 Hospital of People's Liberation ArmyAcademy of Military Medical SciencesBeijing 100071China Department of Gastroenterology and Hepatology 107 Hospital of People's Liberation ArmyYantaiShandong 264002China Department of Bioengineering and Therapeutic Sciences University of CaliforniaSan FranciscoCA 94143-0912USA

Background：perineural invasion （PNI） is a histopathological characteristic of pancreatic cancer （PanCa）.The aim of this study was to observe the treatment effect of continuous low-dose-rate （CLDR） irradiation to PNI and assess the PNI-related pain relief caused by iodine-125 （125I） seed ***：The in vitro PNI model established by co-culture with dorsal root ganglion （DRG） and cancer cells was interfered under 2 and 4 Gy of 125I seeds CLDR *** orthotopic models of PNI were established,and 125I seeds were implanted in *** PNI-related molecules were *** 30 patients with panCa,the pain relief was assessed using a visual analog scale （VAS）.Pain intensity was measured before and 1 week,2 weeks,and 1,3,and 6 months after 125I seed ***：The co-culture of DRG and PanCa cells could promote the growth of PanCa cells and DRG *** co-culture groups,the increased number of DRG neurites and pancreatic cells in radiation group was significantly *** orthotopic models,the PNI-positive rate in radiation and control group was 3/11 and 7/11;meanwhile,the degrees of PNI between radiation and control groups was significant difference （P 〈 0.05）.At week 2,the mean VAS pain score in patients decreased by 50% and significantly improved than the score at baseline （P 〈 0.05）.The pain scores were lower in all patients,and the pain-relieving effect was retained about 3 ***：The CLDR irradiation could inhibit PNI of PanCa with the value of further *** CLDR irradiation could do great favor in preventing local recurrence and alleviating pain.

关键词： Continuous Low-dose-rate Irradiation Pancreatic Cancer perineural invasion Radioactive Seeds

perineural invasion:a potential reason of hepatocellular carcinoma bone metastasis

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Treatment Recommendations among Radiation Oncologists in the Treatment of Cutaneous Squamous Cell Carcinoma with perineural invasion

2016年浙江省骨科学学术年会

作者：王宣伟顾鹏程郭方童翔林向进浙江大学医学院附属第一医院

关键词： Hepatocellular carcinoma bone metastasis perineural invasion nerve density

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Journal of Cancer Therapy 2016年第11期7卷 824-835页

作者： Upendra Parvathaneni Madhu Shetti Daniel Berg Seesha Takagishi George E. Laramore Chrysalyne D. Schmults Anokhi Jambusaria-Pahlajani Stephen D. Hess Marvin Heyboer III Jay J. Liao University of Washington Medical Center Seattle Washington USA Brigham and Women’s Hospital Harvard Medical School Boston Massachusetts USA University of Pennsylvania Philadelphia Pennsylvania USA State University of New York (SUNY) Syracuse New York USA

Purpose: Post-operative radiotherapy (PORT) for resected cutaneous squamous cell carcinoma (CSCC) with perineural invasion (PNI) is controversial. Therefore, we conducted a survey to review treatment recommendations among Radiation Oncologists (ROs) in the management of CSCC with PNI. Materials & Methods: In March 2011, we contacted all ROs and trainees in the US through email addresses listed in the 2009 ASTRO directory. Our web-based survey presented clinical vignettes involving Mohs micrographically resected CSCC with microscopic PNI (mPNI) or clinical PNI (cPNI). For each vignette, ROs were asked to indicate if PORT was appropriate and to further specify the dose and volume to treat. Results: Three hundred fifty two responses were completed and analyzed. The majority of ROs (72%) had over 10 years of post residency experience. 64% of the sampled ROs had a special interest in treating head and neck cancers, and 64% treated 4 or more cases per year. Approximately 95% recommended PORT for cPNI whereas 59% recommended PORT for mPNI. Post residency experience (10+ yrs vs. <10 yrs) was associated with a greater propensity to recommend PORT for mPNI (48% vs. 30%, p = 0.005) and for mPNI of deep subcutaneous non-named nerve involvement (80% vs. 60%, p = 0.001). ROs treating 8 or more cases per year (vs. <7) were more likely to recommend PORT for mPNI in immunocompromised patients (74% vs. 57%, p = 0.01). Conclusions: Our study demonstrates significant variability among ROs in the management of CSCC with mPNI. For cases of cPNI, an overwhelming majority recommended PORT. In cases of mPNI, there was no consensus for recommending PORT, although experienced practitioners had a lower threshold for offering treatment. These results indicate the need for prospective clinical studies to clarify the role of PORT in CSCC patients with mPNI.

关键词： Cutaneous Squamous Cell Carcinoma perineural invasion Head and Neck Post Operative Radiation Therapy

Preoperative perineural invasion in rectal cancer based on deep learning radiomics stacking nomogram: A retrospective study

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Artificial Intelligence in Medical Imaging 2024年第1期5卷 1-12页

作者： Zhi-Chun Zhao Jia-Xuan Liu Ling-Ling Sun Department of Interventional Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Radiology The fourth Affiliated Hospital of China Medical UniversityShenyang 110032Liaoning ProvinceChina

BACKGROUND The presence of perineural invasion(PNI)in patients with rectal cancer(RC)is associated with significantly poorer ***,traditional diagnostic modalities have many *** To develop a deep learning radiomics stacking nomogram model to predict preoperative PNI status in patients with *** We recruited 303 RC patients and separated them into the training(n=242)and test(n=61)datasets on an 8:2 scale.A substantial number of deep learning and hand-crafted radiomics features of primary tumors were extracted from the arterial and venous phases of computed tomography(CT)*** machine learning models were used to predict PNI status in RC patients:support vector machine,k-nearest neighbor,logistic regression,and multilayer *** stacking nomogram was created by combining optimal machine learning models for the arterial and venous phases with predicting clinical *** With an area under the curve(AUC)of 0.964[95%confidence interval(CI):0.944-0.983]in the training dataset and an AUC of 0.955(95%CI:0.900-0.999)in the test dataset,the stacking nomogram demonstrated strong performance in predicting PNI *** the training dataset,the AUC of the stacking nomogram was greater than that of the arterial support vector machine(ASVM),venous SVM,and CT-T stage models(P<0.05).Although the AUC of the stacking nomogram was greater than that of the ASVM in the test dataset,the difference was not particularly noticeable(P=0.05137).CONCLUSION The developed deep learning radiomics stacking nomogram was effective in predicting preoperative PNI status in RC patients.

关键词： Rectal cancer perineural invasion Radiomics Deep learning Machine learning