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Cathepsin C promotes the progression of periapical periodontitis

Science Bulletin 2020年第11期65卷 951-957,M0004页

作者： Wei Yin Ming Dong Dandan Ye Qicheng Liu Shuo Liu Chun Shi Hua Bai Qian Wang Xue Yang Lina Wang Weidong Niu The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine(Ministry of Education) School&Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Biomedical Data Science Geisel School of Medicine at Dartmouth CollegeOne Medical Center DriveLebanonNH 03756USA School of Stomatology Dalian Medical UniversityDalian 116044China Hospital of Stomatology Yiwu CityJinhua 322005China

Although the role of cathepsin C (Cat C) in inflammation is gradually being elucidated, its function in periapical periodontitis, which is one of the most common infectious diseases worldwide, has not been studied. This study evaluated a surgically-induced model of periapical periodontitis in cathepsin C (Cat C) knock-down (KD) mice, which was constructed with a tetracycline operator, to evaluate the role of Cat C in the pathogenesis and progression of periapical periodontitis. Our results showed, for the first time, that there was a statistically significant increase in the expression of Cat C as periapical periodontitis progressed;this increase started from 1 week after surgery and reached a peak at 3 weeks after surgery, before gradually decreasing. The volume of periapical bone resorption in Cat C KD mice was significantly smaller than that in wild-type mice at 3 and 4 weeks after surgery (P<0.05). Inflammatory cell infiltration into the apical tissues of wild-type mice was also significantly higher than that of Cat C KD mice. The expression of receptor activator of nuclear factor-j B ligand (RANKL) in wild-type mice was also higher than that in Cat C KD mice. The difference in the number of osteoclasts in the apical area between the two groups was statistically significant after 2 weeks. Correlation analysis showed that there was a significant correlation between Cat C and RANKL expression (r= 0.835). Therefore, our data indicated that Cat C promoted the apical inflammation and bone destruction in mice.

关键词： Cathepsin C Receptor activator of nuclear factor-B ligand periapical periodontitis Tartrate resistant acid phosphatase

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Root canal therapy combined with endoscopic sinus surgery for odontogenic sinusitis:Efficacy comparison in a cohort study

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World Journal of Clinical Cases 2025年第5期13卷 13-21页

作者： Jun-Wen Xiao Ping Yu Zhang Zhao Department of Stomatology Wuhan No.9 HospitalWuhan 430081Hubei ProvinceChina Department of Otorhinolaryngology People's Hospital of Xishui CountyHuanggang 438200Hubei ProvinceChina Department of Otorhinolaryngology Hubei No.3 People’s Hospital of Jianghan UniversityWuhan 430033Hubei ProvinceChina

BACKGROUND Odontogenic maxillary sinusitis,often triggered by dental issues like periapical periodontitis,significantly contributes to chronic sinusitis,mainly affecting adults around 50 years old,emphasizing the need for a multidisciplinary diagnostic and treatment *** To investigate the therapeutic effect and clinical value of root canal therapy combined with nasal endoscopic surgery compared with simple root canal the-rapy in the treatment of severe odontogenic maxillary sinusitis caused by peria-pical *** The clinical data,diagnosis,and treatment of 200 patients with severe odonto-genic maxillary sinusitis caused by periapical periodontitis from October 2020 to October 2021 were analyzed *** them,63 patients were treated with simple root canal therapy as the control group,and 137 patients were treated with root canal therapy combined with nasal endoscopic surgery as the observation *** therapeutic effect,Lund-Kennedy endoscopic score,paranasal sinus Lund-Mackay score,complication rate,recurrence rate,and patient satisfaction were compared between the two *** First,we compared the effective rates:23 cases were cured,22 were improved,and 8 were ineffective in the control group,yielding a total effective rate of 84.90%.Meanwhile,97 cases were cured,34 improved,and 6 were ineffective in the observation group,resulting in a total effective rate of 95.62%.The observation group had a higher total effective rate compared with the control group(P0.05)was observed in this score between the two *** treatment,the Lund–Kennedy endoscopic score decreased in both *** Lund–Kennedy endoscopic score of the observation group at 3 and 6 mo after treatment was lower compared to that of the control group(P<0.05).Third,we compared the Lund–Mackay score of paranasal *** treatment,there was no si

关键词： Root canal therapy Nasal endoscopic surgery periapical periodontitis Odontogenic maxillary sinusitis Therapeutic effect Clinical value

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Root Canal Treatment Outcome and Restorative Condition of Teeth Treated by Undergraduates—A Clinical and Radiographic Evaluation

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Open Journal of Stomatology 2023年第9期13卷 257-270页

作者： Gabriela Tonet Bassani Bartelle Dianeia Miranda dos Reis Thiago Oliveira Gamba Fabiana Vieira Vier-Pelisser School of Dentistry UCS—Caxias do Sul University Caxias do Sul Brazil School of Dentistry UFRGS—Federal University of Rio Grande do Sul Porto Alegre Brazil

Background: The aim was to evaluate the nonsurgical Root Canal Treatment (nRCT) outcome, the restorative condition and the relationship between the coronal restoration quality and the outcome of teeth endodontic treated by undergraduates at the University of Caxias do Sul School of Dentistry (UCS-SD), Brazil, between 2019 and 2021. Materials and Methods: Data from the endodontically treated cases were retrieved, and the patients were recalled for a follow-up appointment at the university. The endodontic diagnosis, radiographs, and the presence of definitive restorations were analyzed in the clinical records. During the follow-up appointment, endodontically treated teeth were classified as present or absent. The nRCT was classified as successful (complete or incomplete healing) or failure (uncertain or unsatisfactory healing). Coronal restoration was classified as absent or present. When it was present, it was classified as permanent or temporary, and its quality as adequate or inadequate restoration. The results were presented as percentages. Results: A total of 257 teeth were endodontically treated. The most prevalent diagnosis was Chronic Apical periodontitis (33.33%) and the most commonly treated teeth were premolars (46.15%). A total of 52 (21%) treated teeth were clinically and radiographically reexamined. The success rate for the nRCT was 98.08%. About 61.54% of this sample had a definitive composite resin restoration. Conclusion: The nRCT success rate was high. Special attention should be given to the presence and quality of the definitive restoration. Clinical Implications: There was no statistically significant impact between the coronal restoration and the nRCT success (P > 0.05).

关键词： periapical periodontitis Permanent Dental Restoration Permanent Dental Filling Root Canal Obturation Treatment Outcome

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