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Development and validation of an online calculator to predict the pathological nature of colorectal tumors

World Journal of Gastrointestinal Oncology 2023年第7期15卷 1271-1282页

作者： Ya-Dan Wang Jing Wu Bo-Yang Huang Chun-Mei Guo Cang-Hai Wang Hui Su Hong Liu Miao-Miao Wang Jing Wang Li Li Peng-Peng Ding Ming-Ming Meng Department of Gastroenterology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseasesBeijing Digestive Disease CenterBeijing Key Laboratory for Precancerous Lesion of Digestive DiseasesBeijing 100050China Department of Gastroenterology Beijing Shijitan Hospitalthe Ninth Clinical Medicine Peking UniversityBeijing 100038China

BACKGROUND No single endoscopic feature can reliably predict the pathological nature of colorectal tumors(CRTs).AIM To establish and validate a simple online calculator to predict the pathological nature of CRTs based on white-light *** This was a single-center *** the identification stage,530 consecutive patients with CRTs were enrolled from January 2015 to December 2021 as the derivation *** regression analysis was performed.A novel online calculator to predict the pathological nature of CRTs based on white-light images was established and verified *** the validation stage,two series of 110 images obtained using white-light endoscopy were distributed to 10 endoscopists[five highly experienced endoscopists and five less experienced endoscopists(LEEs)]for external validation before and after systematic *** A total of 750 patients were included,with an average age of 63.6±10.4 *** colorectal cancer(ECRC)was detected in 351(46.8%)*** size,left semicolon site,rectal site,acanthosis,depression and an uneven surface were independent risk factors for *** C-index of the ECRC calculator prediction model was 0.906(P=0.225,Hosmer-Lemeshow test).For the LEEs,significant improvement was made in the sensitivity,specificity and accuracy(57.6%vs 75.5%;72.3%vs 82.4%;64.2%vs 80.2%;Ppathological nature of ECRC.

关键词： pathological nature Colorectal tumors White-light endoscopy Online calculator Early colorectal cancer

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