Development and validation of an online calculator to predict the pathological nature of colorectal tumors
作者机构：Department of GastroenterologyBeijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of GastroenterologyBeijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseasesBeijing Digestive Disease CenterBeijing Key Laboratory for Precancerous Lesion of Digestive DiseasesBeijing 100050China Department of GastroenterologyBeijing Shijitan Hospitalthe Ninth Clinical Medicine Peking UniversityBeijing 100038China
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2023年第15卷第7期
页 面：1271-1282页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Capital’s Funds for Health Improvement and Research,No.2020-4-2085 Beijing Science and Technology Plan Project,No.Z211100002921028
主 题：Pathological nature Colorectal tumors White-light endoscopy Online calculator Early colorectal cancer
摘 要：BACKGROUND No single endoscopic feature can reliably predict the pathological nature of colorectal tumors(CRTs).AIM To establish and validate a simple online calculator to predict the pathological nature of CRTs based on white-light *** This was a single-center *** the identification stage,530 consecutive patients with CRTs were enrolled from January 2015 to December 2021 as the derivation *** regression analysis was performed.A novel online calculator to predict the pathological nature of CRTs based on white-light images was established and verified *** the validation stage,two series of 110 images obtained using white-light endoscopy were distributed to 10 endoscopists[five highly experienced endoscopists and five less experienced endoscopists(LEEs)]for external validation before and after systematic *** A total of 750 patients were included,with an average age of 63.6±10.4 *** colorectal cancer(ECRC)was detected in 351(46.8%)*** size,left semicolon site,rectal site,acanthosis,depression and an uneven surface were independent risk factors for *** C-index of the ECRC calculator prediction model was 0.906(P=0.225,Hosmer-Lemeshow test).For the LEEs,significant improvement was made in the sensitivity,specificity and accuracy(57.6%vs 75.5%;72.3%vs 82.4%;64.2%vs 80.2%;P0.05),respectively,after training with the ECRC online calculator prediction *** A novel online calculator including tumor size,location,acanthosis,depression,and uneven surface can accurately predict the pathological nature of ECRC.
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