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Papillary cystadenoma of the parotid gland: A case report

World Journal of Clinical Cases 2019年第3期7卷 366-372页

作者： Li Wang Shi-Kun Zhang Ying Ma Patrick K Ha Zhi-Ming Wang Department of Oral and Maxillofacial Surgery Shengjing Hospital of China Medical University Department of Pathology Shengjing Hospital of China Medical University Division of Head and Neck Oncologic and Endocrine Surgery Department of Otolaryngology-Head and Neck Surgery University of California-San Francisco

BACKGROUND Papillary cystadenoma is a rare benign epithelial tumor of the salivary gland,which is characterized by papillary structures and oncocytic cells with rich eosinophilic cytoplasm. We found only one case of papillary cystadenoma in nearly 700 cases of salivary gland tumors. Our case was initially mistaken for a tumor of the right temporomandibular joint(TMJ) capsule rather than of parotid gland origin. Preoperative magnetic resonance imaging(MRI) and computed tomography(CT) should be carefully studied, which allows for appropriate preoperative counseling and operative *** SUMMARY Here, we report an unusual case of a 54-year-old woman with a parotid gland papillary cystadenoma(PGPC) that was misdiagnosed as a tumor of the right TMJ capsule. She was initially admitted to our hospital due to a mass anterior to her right ear inadvertently found 5 d ago. Preoperative CT and MRI revealed a well circumscribed tumor that was attached to the right TMJ capsule. The patient underwent a resection through an incision for TMJ, but evaluation of an intraoperative frozen section revealed a benign tumor of the parotid gland. Then we removed part of the parotid gland above the temporal facial trunk. The facial nerve was preserved. Postoperative histopathological findings revealed that the tumor was PGPC. No additional treatment was performed. There was no recurrence during a 20-mo follow-up *** The integrity of the interstitial space around the condyle in MRI or CT should be carefully evaluated for parotid gland or TMJ tumors.

关键词： Papillary cystadenoma parotid gland Temporomandibular joint Case report

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parotid swelling due to Hoshino strain following MMR vaccination in iranian immunization program

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Asian Pacific Journal of Tropical Medicine 2008年第3期1卷 79-82页

作者： Majid Avijgan Mandana Moghni Seyyed Kamyar Mostafavi Zadeh Department of Infectious And Tropical diseases Isfahan University of Medical Sciences Shahr-e-kord University of Medical Sciences Department of Infectious And Tropical disease Isfahan University of Medical Sciences

This paper reports two seronegative cases of parotid swelling following MMR vaccination,which contains Hoshino strain of mumps *** study showed a high,(5%) potential reactogenicity induced by Hoshino strain of current MMR vaccine administered in Iranian *** rate of complication of parotid swelling following national immunization against mumps is more than natural *** on the results of this report, there is the first report of occurrence of parotid swelling 31 days following MMR *** reaction or complication may not be dependent on the vaccine dose,because one of cases presented parotid swelling following taking one fifth of conventional dose of *** must be considered this strain may be with high rate of complication and be the subject of change of mumps strain of this vaccine in national immunization program of Iran.

关键词： mumps MMR parotid swelling reaction vaccine vaccine dose

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Diffuse large B-cell lymphoma arising from follicular lymphoma with warthin’s tumor of the parotid gland-immunophenotypic and genetic features: A case report

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World Journal of Clinical Cases 2019年第22期7卷 3895-3903页

作者： Chang-Song Wang Xia Chu Di Yang Lei Ren Nian-Long Meng Xue-Xia Lv Tian Yun Yan-Sha Cao Department of Pathology 989th Hospital of PLALuoyang 471000Henan ProvinceChina Department of Pathology 988^th Hospital of PLAZhengzhou 450042Henan ProvinceChina Department of Pathology Sanmenxia center HospitalSanmenxia 472000Henan ProvinceChina Department of Pathology Luoyang First People’s HospitalLuoyang 471000Henan ProvinceChina

BACKGROUND Warthin’s tumor(WT)is composed of several cysts that are lined with tall,bilayered oncocytic columnar cells and lymphoid *** WT,the two components rarely transform into carcinoma or lymphoma,and when it does,carcinoma is the most common *** 28 cases of lymphoma with WT have been reported,most of which were non-Hodgkin lymphomas,and only a few cases were Hodgkin *** the present report,we studied a case of diffuse large B cell lymphoma(DLBCL)arising from follicular lymphoma(FL)with WT in the parotid gland and its immunophenotypic and genetic *** SUMMARY A 67-year-old man presented with a slowly enlarging right cheek mass for 12 years,and the mass began to change in size over a 2-mo time *** time,the patient felt mild local pain and right cheek *** medical history included a hepatitis B virus infection for 20 years and 30 years of *** examination of the excised specimen showed a gray-red and gray-white appearance and a soft texture lobulated external surface neoplasm that measured 9 cm×8 cm×7 cm and was well circumscribed by relative normal parotid gland *** cross section,the cut surfaces of the neoplasm were multicystic and had a homogeneous scaly appearance.A small fluid was discovered in the *** oxyphilic,cuboidal or polygonal epithelium cells and lymphoid intraparenchymal components were *** medium-to large-sized lymphoid cells were observed diffusely in part of the neoplasm,and a few secondary lymphoid follicles were observed at the center or edge of the *** staining showed that the columnar oncocytic cells were positive for AE1/AE3;neoplastic cells located in coarctate follicular were positive for CD20,Pax-5,bcl-2 and bcl-6;and the adjacent diffusely medium-to large-sized lymphoid cells were positive for Pax-5,bcl-6,CD20,MUM-1,bcl-2 and *** bcl-6(3q27)break-apart rearrangement was observed,and an Epstein Barr virus test was

关键词： Diffuse large B cell lymphoma Warthin’s tumor parotid gland Follicularlymphoma Case report Genetic feature

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A large basal cell adenoma extending to the ipsilateral skull base and mastoid in the right parotid gland: A case report

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World Journal of Clinical Cases 2019年第11期7卷 1351-1357页

作者： Lu-Yang Du Xiu-Hong Weng Zhen-Yu Shen Bo Cheng Department of Stomatology Union Hospital Tongji Medical College HuaZhong University of Science and Technology Wuhan 430022 Hubei Province China Department of Stomatology Zhongnan Hospital of Wuhan University Wuhan 430071 Hubei Province China

BACKGROUND Basal cell adenoma (BCA) is a rare benign tumour that has unique histological characteristics and primarily arises in the parotid glands. According to published reports, nearby tissue destruction by BCA seems impossible. CASE SUMMARY We presented a case of a 54-year-old woman with a mass in the deep lobe of the right parotid gland involving the ipsilateral skull base and mastoid. The patient exhibited gradual right facial swelling but no other obvious symptoms. Combined resection of the total right parotid gland and partial skull base excision were performed. The biopsy conducted before the surgery and sections cut from intraoperatively obtained tissues were not definitive for identifying the character of the neoplasm. A final diagnosis of tubular BCA without malignant elements was established based on postoperative pathology results and immunohistochemical analysis. The tumour did not recur during the 12-mo follow-up period. CONCLUSION A diagnosis of BCA can only be established based on a histopathological examination after an excisional biopsy, and tubular BCA should carefully be considered as a destructive type.

关键词： Basal cell adenoma Mastoid parotid gland Skull base Total parotidectomy Case report

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Bilateral parotid enlargement following snake bite:A rare sign

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Asian Pacific Journal of Tropical Biomedicine 2013年第2期3卷 154-155页

作者： Madi Deepak Achappa Basavaprabhu John T Ramapuram Chowta Nithyananda Soundarya Mahalingam Department of Medicine Kasturba Medical CollegeMangalore(Manipal University) Department of Paediatrics Kasturba Medical CollegeMangalore(Manipal University)

Snakebite is a common medical emergency in *** complications may occur after viper *** parotid enlargement after viper bite is a rare *** 18-year old gentleman presented to our hospital with history of viper *** examination he had cellulitis of right lower *** developed swelling of both the parotid glands 12 h after *** developed coagulopathy,acute renal failure and died within 48 h of hospital *** of parotid swelling after snake bite is associated with poor *** case is found worth reporting as it is an unusual complication having prognostic value.

关键词： Snakebite parotid swelling Coagulopathy

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parotid Lipoma: A Case Report

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Case Reports in Clinical Medicine 2014年第7期3卷 437-442页

作者： Massimo Mesolella Filippo Ricciardiello Flavia Oliva Teresa Abate Antonella Miriam Di Lullo Anna Marino ENT Department University “Federico II” Naples Italy

Lipoma is a common benign tumor affecting the soft tissues arising in every location where fat is normally present. About 15% of lipomas occur in head and neck region. The lipoma of parotid gland is a rare entity, comprising 0.6% - 4.4% of all parotid tumors. The etiology remains unclear. The case described a lipoma of the superficial lobe of the parotid gland in a 46-year-old male.

关键词： Lipoma parotid Gland parotidectomy

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parotid lymph node metastasis in a patient with tongue cancer

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Case Reports in Clinical Medicine 2014年第1期3卷 23-27页

作者： Kenji Yamagata Naomi Ishibashi Kanno Hiroyuki Ito Shogo Hasegawa Toru Yanagawa Kojiro Onizawa Hiroki Bukawa Department of Oral and Maxillofacial Surgery Faculty of Medi-cine University of Tsukuba Tsukuba Japan

parotid lymph node (LN) metastasis occurs most commonly from cutaneous squamous cell carcinoma (CSCC) of the head and neck, but rarely from oral squamous cell carcinoma (OSCC). Here, we present a rare case of metastasis to the parotid LN in a patient with tongue cancer. Although usual extent of modified radical neck dissection that includes resection of the tail of the parotid gland is below the line of the mandibular angle and the mastoid process was performed, the parotid LN metastasis occurred. The patient was treated with partial parotidectomy and chemoradiotherapy. One year and two months later, there was no evidence of local recurrence, although multiple lung metastases were observed. We also review the literature on parotid LN metastasis from OSCC.

关键词： Oral Squamous Cell Carcinoma (OSCC) parotid Lymph Node Metastases Tongue Cancer

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Partial Purification and Characterization of the Rat parotid Gland Protein Kinase Catalyzing Phosphorylation of Matured Destrin at Ser-2

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Advances in Enzyme Research 2014年第2期2卷 100-112页

作者： Eriko Osumi Chihiro Kondo Mitsumasa Mizuno Takahiro Suzuki Mamoru Matsubara Kazuo Shimozato Takao Kanamori Department of Biochemistry School of Dentistry Aichi-Gakuin University Nagoya Japan Department of Bioscience and Biotechnology Faculty of Bioenvironmental Science Kyotogakuen University Kyoto Japan Department of Maxillofacial Surgery School of Dentistry Aichi-Gakuin University Nagoya Japan

Destrin, also called actin-depolymerizing factor (ADF), exists in resting parotid tissue as phosphorylated (inactive) and dephosphorylated (active) forms, and β-adrenergic stimulation of this tissue induces dephosphorylation of destrin. It is suggested that destrin dephosphorylation is involved in cortical F-actin disruption observed in parallel with β-agonist-induced amylase secretion. At present, the phosphorylation/dephosphorylation mechanism of destrin in parotid tissue is not known. We previously detected, in a crude rat parotid extract, a constitutively active protein kinase catalyzing phosphorylation of destrin;however, its identification has been hampered by difficulty in its enrichment. The purpose of this study was to explore a simple purification method(s) for this enzyme. To this end, we first developed a high-throughput dot-blot assay for the kinase with an anti-phosphodestrin antibody and then studied its purification by column chromatography on several media. We found that the kinase could be partially purified by sequential chromatography on DEAE-cellulose, phenyl-Sepharose, and hydroxyapatite columns. In each chromatography, however, the kinase could be eluted, at the cost of resolution, only by sharp increases in the elution power of the eluent;gradual increases in the elution power resulted in unacceptably poor recovery. We confirmed that enzymatic properties of the kinase were not basically altered during the purification. Further purification of the kinase was achieved by native polyacrylamide gel electrophoresis (PAGE), which resolved the kinase activity into two bands and separated the activity from most proteins (the kinase activity after PAGE was detected with destrin-coated polyvinylidene difluoride membranes and the anti-phosphodestrin antibody). The two bands seem to constitute the major destrin-phosphorylating activity in the resting rat parotid gland. We here report its partial purification and characterization together with the detecti

关键词： Protein Kinase Purification Protein Kinase Assay Destrin Kinase Actin-Depolymerizing Factor Rat parotid Gland

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Dose-Response Relationship between Dietary Polyphenols from Acorns and parotid Gland Hypertrophy in Pigs

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Food and Nutrition Sciences 2012年第9期3卷 1261-1268页

作者： Maria Grazia Cappai Petra Wolf Walter Pinna Josef Kamphues Institute of Animal Nutrition University of Veterinary Medicine Hannover Foundation Bischofsholer Dam Hannover Germany Research Unit of Animal Husbandry Sciences Department of Agriculture University of Sassari via Vienna ex-Faculty of Vete-rinary Medicine Sassari Italy

Proline contents of parotid glands (PG) in pigs constantly increase after the inclusion of different amounts of ripe hulled acorns in the diet providing high polyphenols levels. The dose-response relationship was estimated on natural hydrolizable tannins (expressed as tannic acid equivalent TAE) amounts of 25.8 to 36.1 g TAE/kg DM in experimental diets. Macroscopic and histological morphometry of parotid glands greatly varied according to feed intake and dosages of TAE ingested. The PG response (hypertrophy grade) on acorns’ tannins content in the diet was positively correlated (R2 = 0.748): the response to the protein precipitating activity (PPA) of tannins consisted of a functional parotidomegaly (hypertrophy), 1.34 up to 3.55 folds than control PGs, following an oral dosage 0.596 up 1.72 TAE g·kg body weight·d-1 respectively, after one week exposure.

关键词： Acorns parotid Gland Polyphenols Hypertrophy Proline Secretory Response

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Evaluation of Preoperative Fine Needle Aspiration Accuracy in Diagnosis of Malignant parotid Tumors

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International Journal of Otolaryngology and Head & Neck Surgery 2020年第3期9卷 101-110页

作者： Alaa Q. Mandeel Esra M. Qadami Zahra A. Abdeen Sayed Ali I. Al Mahari Sayed Husain A. Alawi Department of Otorhinolaryngology Salmaniya Medical Complex Manama Kingdom of Bahrain Department of Histopathology Salmaniya Medical Complex Manama Kingdom of Bahrain

Objective: To evaluate the diagnostic accuracy of fine needle aspiration (FNA) in detecting malignant parotid tumors. Design: A retrospective study of cases series. Setting: Salmaniya Medical Complex, Otorhinolaryngology Department, Kingdom of Bahrain. Methods: A retrospective study was carried out, between January 2009 and December 2018, for all patients diagnosed with parotid tumors at the Department of Otorhinolaryngology, Head and Neck Surgery at Salmaniya Medical Complex, Manama, Kingdom of Bahrain. Data collection was made from medical records, I-seha and laboratory information system (LIS). 87 patients underwent parotidectomy, of which 30 were excluded due to unsatisfactory diagnoses or missing data. The results of fine needle aspirations were analyzed and compared with the corresponding histopathologic diagnosis. Estimation of sensitivity, specificity, negative predictive value, positive predictive value and accuracy of FNA were calculated. Results: Among the 57 evaluated cases, four cases were further excluded from the final analysis due to unsatisfactory FNA results, therefore only 53 cases remained. The mean age of patients was 48.6 ± 17.2 years. A concordance with histopathology results was observed. 47 cases were diagnosed as benign and five cases were malignant, however, 1 case was diagnosed as malignant by FNA, but not in histopathology. The overall diagnostic accuracy was 98.1% and the prevalence of parotid malignancy was 9.4%. Sensitivity and specificity were 100% and 97.9%, respectively. Positive predictive value was 83.3% while negative predictive value was 100%. Conclusion: Fine needle aspiration is a highly sensitive and specific test in evaluating malignant parotid gland tumors. It is useful and accurate, especially when used hand by hand with the clinical assessment and radiological findings.

关键词： Fine Needle Aspiration Histopathology Malignant parotid Salmaniya Medical Complex Tumors

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