Diffuse large B-cell lymphoma arising from follicular lymphoma with warthin’s tumor of the parotid gland-immunophenotypic and genetic features: A case report
Diffuse large B-cell lymphoma arising from follicular lymphoma with warthin’s tumor of the parotid gland-immunophenotypic and genetic features: A case report作者机构：Department of Pathology989th Hospital of PLALuoyang 471000Henan ProvinceChina Department of Pathology988^th Hospital of PLAZhengzhou 450042Henan ProvinceChina Department of PathologySanmenxia center HospitalSanmenxia 472000Henan ProvinceChina Department of PathologyLuoyang First People’s HospitalLuoyang 471000Henan ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2019年第7卷第22期
页 面：3895-3903页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Diffuse large B cell lymphoma Warthin’s tumor Parotid gland Follicularlymphoma Case report Genetic feature
摘 要：BACKGROUND Warthin’s tumor(WT)is composed of several cysts that are lined with tall,bilayered oncocytic columnar cells and lymphoid *** WT,the two components rarely transform into carcinoma or lymphoma,and when it does,carcinoma is the most common *** 28 cases of lymphoma with WT have been reported,most of which were non-Hodgkin lymphomas,and only a few cases were Hodgkin *** the present report,we studied a case of diffuse large B cell lymphoma(DLBCL)arising from follicular lymphoma(FL)with WT in the parotid gland and its immunophenotypic and genetic *** SUMMARY A 67-year-old man presented with a slowly enlarging right cheek mass for 12 years,and the mass began to change in size over a 2-mo time *** time,the patient felt mild local pain and right cheek *** medical history included a hepatitis B virus infection for 20 years and 30 years of *** examination of the excised specimen showed a gray-red and gray-white appearance and a soft texture lobulated external surface neoplasm that measured 9 cm×8 cm×7 cm and was well circumscribed by relative normal parotid gland *** cross section,the cut surfaces of the neoplasm were multicystic and had a homogeneous scaly appearance.A small fluid was discovered in the *** oxyphilic,cuboidal or polygonal epithelium cells and lymphoid intraparenchymal components were *** medium-to large-sized lymphoid cells were observed diffusely in part of the neoplasm,and a few secondary lymphoid follicles were observed at the center or edge of the *** staining showed that the columnar oncocytic cells were positive for AE1/AE3;neoplastic cells located in coarctate follicular were positive for CD20,Pax-5,bcl-2 and bcl-6;and the adjacent diffusely medium-to large-sized lymphoid cells were positive for Pax-5,bcl-6,CD20,MUM-1,bcl-2 and *** bcl-6(3q27)break-apart rearrangement was observed,and an Epstein Barr virus test was
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