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Paradoxical systemic toxicity by inhaled paraquat poisoning: A case report

Journal of Acute Disease 2024年第1期13卷 40-42,I0001-I0005页

作者： Tulika Garg Jaspreet Kaur Yuvraj Singh Cheema Department of General Medicine Government Medical College and HospitalChandigarhIndia

Rationale:Multi-organ failure is a symptom of paraquat poisoning,resulting in high mortality and morbidity *** paraquat is widely available,poisoning through inhalation is ***’s Concern:A 37-year-old male reported to the emergency department with complaints of vomiting after an alleged history of inhalation of paraquat while at ***:paraquat ***:Supportive management along with multiple sessions of ***:Renal complications caused by paraquat were improved after multiple sessions of ***,the patient developed respiratory complications and later due to persistent hypoxemia and non-responsive to supportive therapy,he succumbed to his ***:Acute kidney injury is a complication of paraquat ***,kidney involvement with the inhalational mode is *** is caused by reduction and oxidation cycles,as well as the formation of reactive oxygen species,necessitating hemodialysis as the *** a clear history,a specific clinical trait,or a diagnostic test,diagnosis can be *** case thus highlights the inhaled paraquat poisoning,presenting with acute kidney injury with late respiratory impairment as a consequence.

关键词： paraquat poisoning Pesticide Acute kidney injury Respiratory insufficiency Hemodialysis

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Anthrahydroquinone-2,6-disulfonate alleviates paraquat-induced kidney injury via the apelin-APJ pathway in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第8期12卷 333-342页

作者： Qi Li Bo Wang Kai-Wen Lin Tang Deng Qi-Feng Huang Shuang-Qin Xu Hang-Fei Wang Xin-Xin Wu Nan Li Yang Yi Ji-Chao Peng Yue Huang Jin Qian Xiao-Ran Liu College of Emergency and Trauma Hainan Medical UniversityKey Laboratory of Emergency and Trauma of Ministry of EducationThe First Affiliated Hospital of Hainan Medical UniversityHaikou 571199China Jiangdong Health Center Meilan DistrictHaikou 571126China Hainan Women and Children's Medical Center Haikou 570312China

Objective:To explore the protective effects of anthrahydroquinone-2,6-disulfonate(AH_(2)QDS)on the kidneys of paraquat(PQ)poisoned rats via the apelin-APJ ***:Male Sprague Dawley rats were divided into four experimental groups:control,PQ,PQ+sivelestat,and PQ+AH_(2)*** PQ+sivelestat group served as the positive control *** model of poisoning was established via intragastric treatment with a 20%PQ pesticide solution at 200 mg/*** hours after poisoning,the PQ+sivelestat group was treated with sivelestat,while the PQ+AH_(2)QDS group was given AH_(2)*** rats were selected from each group on the first,third,and seventh days after poisoning and dissected after *** PQ content of the kidneys was measured using the sodium disulfite ***-eosin staining of renal tissues was performed to detect pathological *** expression in the renal tissues was detected using *** blotting was used to detect the expression levels of the following proteins in the kidney tissues:IL-6,TNF-α,apelin-APJ(the apelin-angiotensin receptor),NF-κB p65,caspase-1,caspase-8,glucose-regulated protein 78(GRP78),and the C/EBP homologous protein(CHOP).In in vitro study,a PQ toxicity model was established using human tubular epithelial cells treated with standard ***-four hours after poisoning,sivelestat and AH_(2)QDS were *** levels of oxidative stress in human renal tubular epithelial cells were assessed using a reactive oxygen species fluorescence ***:The PQ content in the kidney tissues of the PQ group was higher than that of the PQ+AH_(2)QDS ***-eosin staining showed extensive hemorrhage and congestion in the renal parenchyma of the PQ *** degeneration of the renal tubule epithelial cells,deposition of crescent-like red staining material in renal follicles,infiltration by a few inflammatory cells,and a small number of cast formation were also ***,these pat

关键词： paraquat poisoning AH2QDS Apelin/APJ Acute kidney injury Oxidative stress Rat Human tubular epithelial cell

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Successful treatment of patients with paraquat intoxication:three case reports and review of the literature

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第5期13卷 413-418页

作者： Qin ZHANG Wei-zhen WU Yuan-qiang LU Jie-zan WANG An-dong SHANG Feng YAO Yan CHEN Department of Emergency the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Dep rtrnent of Geriatricsthe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Objective: To report on three patients with paraquat (PQ) intoxication surviving after combined therapy with hemoperfusion (HP), cyclophosphamide (CTX), and glucocorticoid. Methods: Three patients suffered acute renal failure in a few days after ingesting a lethal amount of PQ. Chest computed tomography (CT) scans revealed obvious pulmonary inflammation, pleural effusion, and fibrous lesions several days after ingestion. HP was performed immediately, followed by large doses of glucocorticoid (methylprednisolone, 500 g/d) and CTX (approximately 4 g). Results: After 50 d of treatments, all three patients were discharged in healthy condition, with chest CT showing small fibrous lesions, exuda- tion, and both lungs clear of auscultation. Conclusions: The protective effect of the lungs may have been due to timely treatment at adequate doses.

关键词： paraquat poisoning Hemoperfusion Glucocorticoid Cyclophosphamide

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百草枯中毒的预后因素分析

百草枯中毒的预后因素分析

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作者：刘颖中国医科大学

学位级别：硕士

目的:了解百草枯中毒的临床过程,分析其预后的影响因素,探讨提高生存率的有效治疗方法。方法:对13例百草枯中毒患者临床资料进行回顾性分析。结果:11例患者于院内死亡,2例患者存活出院(平均年龄17.0±1.41)经跟踪调查死亡,总死亡率达到1... 详细信息

目的:了解百草枯中毒的临床过程,分析其预后的影响因素,探讨提高生存率的有效治疗方法。方法:对13例百草枯中毒患者临床资料进行回顾性分析。结果:11例患者于院内死亡,2例患者存活出院(平均年龄17.0±1.41)经跟踪调查死亡,总死亡率达到100%。4例患者接受血液净化治疗,其循环衰竭的发生率为0,无血液净化治疗组循环衰竭及肾功能衰竭的发生率为55.6%。9例患者给予抗氧化剂及激素治疗,其中8例(88.9%)存活时间明显延长但仍死于肺损伤。结论:百草枯中毒病死率极高,中毒后3天内可死于循环衰竭,经过血液净化治疗的患者可以纠正循环及肾功能衰竭,早期存活,但多于中毒后5—7天发生明显肺损伤,2—3周达到高峰最终死于呼吸衰竭。并发SIRS、MODS,尤其肺、肾、肝、胃肠道及心肌出现3个以上脏器损伤的死亡率高。应用抗氧化剂及激素治疗可以延长患者生存时间,但阻滞肺纤维化发生的作用不显著,仍不能提高患者长期生存率。

关键词： paraquat poisoning Treatment Radiology Prognosis

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