Successful treatment of patients with paraquat intoxication:three case reports and review of the literature

作     者：Qin ZHANG Wei-zhen WU Yuan-qiang LU Jie-zan WANG An-dong SHANG Feng YAO Yan CHEN 

作者机构：Department of Emergencythe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Deprtrnent of Geriatricsthe First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2012年第13卷第5期

页      面：413-418页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 0905[农学-畜牧学] 0906[农学-兽医学] 100402[医学-劳动卫生与环境卫生学] 10[医学] 

主　　题：Paraquat poisoning Hemoperfusion Glucocorticoid Cyclophosphamide 

摘      要：Objective: To report on three patients with paraquat (PQ) intoxication surviving after combined therapy with hemoperfusion (HP), cyclophosphamide (CTX), and glucocorticoid. Methods: Three patients suffered acute renal failure in a few days after ingesting a lethal amount of PQ. Chest computed tomography (CT) scans revealed obvious pulmonary inflammation, pleural effusion, and fibrous lesions several days after ingestion. HP was performed immediately, followed by large doses of glucocorticoid (methylprednisolone, 500 g/d) and CTX (approximately 4 g). Results: After 50 d of treatments, all three patients were discharged in healthy condition, with chest CT showing small fibrous lesions, exuda- tion, and both lungs clear of auscultation. Conclusions: The protective effect of the lungs may have been due to timely treatment at adequate doses.