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Malignant atrophic papulosis:Two case reports

World Journal of Clinical Cases 2022年第35期10卷 12971-12979页

作者： Zhi-Gui Li Jia-Ming Zhou Li Li Xiao-Dong Wang Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Clinical Medicine West China School of MedicineSichuan UniversityChengdu 610207Sichuan ProvinceChina

BACKGROUND Malignant atrophic papulosis is a rare and potentially lethal thrombo-occlusive microvasculopathy characterized by cutaneous papules and gastrointestinal *** precise pathogenesis of this disease remains *** SUMMARY We describe the case of a 67-year-old male patient who initially presented with cutaneous aubergine papules and dull pain in the *** week after symptom onset,he was admitted to the hospital for worsening abdominal *** laparotomy showed patchy necrosis and subserosal white plaque lesions on the small intestinal wall,along with multiple *** examination of the small intestine showed extensive hyperemia,edema,necrosis with varying degrees of inflammatory reactions in the small bowel wall,small vasculitis with fibrinoid necrosis and intraluminal thrombosis in the *** on the mentioned evidence,a diagnosis of malignant atrophic papulosis was *** also present the case of a 46-year-old man with known cutaneous manifestations,abdominal pain,nausea and *** physical examination showed positive rebound tenderness.A computed tomography scan revealed free intraperitoneal *** required surgical intervention on admission and then developed an esophageal *** ultimately died of a massive *** In previously published cases of this disease,the cutaneous lesions initially appeared as small erythematous ***,the papules became porcelain-white atrophic depression lesions with a pink,telangiectatic peripheral *** one of the patients,the cutaneous lesions appeared as aubergine *** other patient developed multiple perforations in the gastrointestinal *** to malignant atrophic papulosis affecting multiple organs,many authors speculated that it is not a specific *** case series serves as additional evidence for our hypothesis.

关键词： Malignant atrophic papulosis Gastrointestinal perforation papulosis Thrombo-occlusive microvasculopathy Case report

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Lymphomatoid papulosis type D: three case reports

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International Journal of Dermatology and Venereology 2018年第2期1卷 111-116页

作者： Hai-Lun Wang Hao-Ze Shi Jing-Shu Xiong Hao Chen Jian-Fang Sun Department of Pathology Guangzhou KingMed Dignostics Guangzhou Guangdong 510330 China Department of Pathology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing Jiangsu 210042 China

Three cases of lymphomatoid papulosis (LyP) type D were *** is a new reported morphological subtype of LyP *** D LyP manifests marked epidermotropism and shows coexpression of CD8 and *** is necessary to differentiate Type D LyP from other benign and malignant diseases which have similar clinical and histopathological *** of this entity can lead to correct diagnosis of this disease.

关键词： Lymphomatoid papulosis type D Epidermotropism CD8 positive

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A fatal case of Degos' disease which presented with recurrent intestinal perforation

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World Journal of Gastrointestinal Surgery 2011年第10期3卷 156-158页

作者： Mona Ahmadi Sevil Agabalaey Rafi Zhale Faham Ramin Azhough Samad Beheshty Rooy Omid Rahmani Department of General Surgery and Pathology Imam Reza Hospital

Degos' disease,otherwise known as "malignant atrophic papulosis" is a rare vasculopathy with an unknown etiology characterized by typical cutaneous *** of the gastrointestinal(GI) tract is observed in approximately half of patients and small infarctions in the mucosa can cause perforation and resulting peritonitis,the leading cause of *** present a fatal case of Degos' disease with skin and GI involvement,manifesting as recurrent intestinal perforations and peritonitis,in a 15-year-old Iranian boy.

关键词： Degos’disease Malignant atrophic papulosis Small bowel perforation

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