Malignant atrophic papulosis:Two case reports
作者机构：Department of Gastrointestinal SurgeryWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Clinical MedicineWest China School of MedicineSichuan UniversityChengdu 610207Sichuan ProvinceChina
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2022年第10卷第35期
页 面：12971-12979页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Key Project of Science and Technology Department of Sichuan Province No.2022YFS0337
主 题：Malignant atrophic papulosis Gastrointestinal perforation Papulosis Thrombo-occlusive microvasculopathy Case report
摘 要：BACKGROUND Malignant atrophic papulosis is a rare and potentially lethal thrombo-occlusive microvasculopathy characterized by cutaneous papules and gastrointestinal *** precise pathogenesis of this disease remains *** SUMMARY We describe the case of a 67-year-old male patient who initially presented with cutaneous aubergine papules and dull pain in the *** week after symptom onset,he was admitted to the hospital for worsening abdominal *** laparotomy showed patchy necrosis and subserosal white plaque lesions on the small intestinal wall,along with multiple *** examination of the small intestine showed extensive hyperemia,edema,necrosis with varying degrees of inflammatory reactions in the small bowel wall,small vasculitis with fibrinoid necrosis and intraluminal thrombosis in the *** on the mentioned evidence,a diagnosis of malignant atrophic papulosis was *** also present the case of a 46-year-old man with known cutaneous manifestations,abdominal pain,nausea and *** physical examination showed positive rebound tenderness.A computed tomography scan revealed free intraperitoneal *** required surgical intervention on admission and then developed an esophageal *** ultimately died of a massive *** In previously published cases of this disease,the cutaneous lesions initially appeared as small erythematous ***,the papules became porcelain-white atrophic depression lesions with a pink,telangiectatic peripheral *** one of the patients,the cutaneous lesions appeared as aubergine *** other patient developed multiple perforations in the gastrointestinal *** to malignant atrophic papulosis affecting multiple organs,many authors speculated that it is not a specific *** case series serves as additional evidence for our hypothesis.
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