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Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma

World Journal of Gastrointestinal Oncology 2025年第1期17卷 199-206页

作者： Radu Cristian Poenaru Elena Milanesi Andrei Marian Niculae Anastasia-Maria Dobre Catalina Vladut Mihai Ciocîrlan Daniel Vasile Balaban Vlad Herlea Maria Dobre Mihail Eugen Hinescu Faculty of Medicine Carol Davila University of Medicine and PharmacyBucharest 050474Romania Department of Radiobiology Victor Babes National Institute of PathologyBucharest 050096Romania Department of Pathology Victor Babes National Institute of PathologyBucharest 050096Romania Department of Gastroenterology Prof.Dr.Agrippa Ionescu Clinical Emergency HospitalBucharest 011356Romania Department of Pathology Fundeni Clinical InstituteBucharest 022258Romania

BACKGROUND pancreatic ductal adenocarcinoma(PDAC)is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11%in the United *** for other types of tumors,such as colorectal cancer,aberrant de novo lipid synthesis and reprogrammed lipid metabolism have been suggested to be associated with PDAC development and *** To identify the possible involvement of lipid metabolism in PDAC by analyzing in tumoral and non-tumoral tissues the expression level of the most relevant genes involved in the long-chain fatty acid(FA)import into *** A gene expression analysis of FASN,CD36,SLC27A1,SLC27A2,SLC27A3,SLC27A4,SLC27A5,ACSL1,and ACSL3 was performed by qRT-PCR in 24 tumoral PDAC tissues and 11 samples from non-tumoral pancreatic tissues obtained via fine needle aspiration or via surgical *** genes were considered significantly dysregulated between the groups when the p value was<0.05 and the fold change(FC)was≤0.5 and≥*** We found that three FA transporters and two long-chain acyl-CoA synthetases genes were significantly upregulated in the PDAC tissue compared to the non-tumoral tissue:SLC27A2(FC=5.66;P=0.033),SLC27A3(FC=2.68;P=0.040),SLC27A4(FC=3.13;P=0.033),ACSL1(FC=4.10;P<0.001),and ACSL3(FC=2.67;P=0.012).We further investigated any possible association between the levels of the analyzed mRNAs and the specific characteristics of the tumors,including the anatomic location,the lymph node involvement,and the presence of metastasis.A significant difference in the expression of SLC27A3(FC=3.28;P=0.040)was found comparing patients with and without lymph nodes involvement with an overexpression of this transcript in 17 patients presenting tumoral cells in the lymph *** Despite the low number of patients analyzed,these preliminary results seem to be *** lipid metabolism through a broad strategy could be a beneficial way to treat this *** in vitro and in vivo s

关键词： Carcinoma pancreatic ductal Fatty acid transport Gene expression Biomarkers

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Two cases of pancreatic ductal adenocarcinoma with intrapancreatic metastasis

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World Journal of Gastroenterology 2016年第41期22卷 9222-9228页

作者： Yusuke Fujita Minoru Kitago Yohei Masugi Osamu Itano Masahiro Shinoda Yuta Abe Taizo Hibi Hiroshi Yagi Yoko Fujii-Nishimura Michiie Sakamoto Yuko Kitagawa Department of Surgery Keio University School of Medicine Department of Pathology Keio University School of Medicine

There are no standardized diagnostic criteria for intrapancreatic metastasis of pancreatic ductal adenocarcinoma(PDAC). Here, we report two cases of patients with PDAC who were pathologically diagnosed as harboring intrapancreatic metastasis. In both cases, the main lesions were located in the pancreatic body, and no other lesion was detected preoperatively. The patients were diagnosed with pancreatic body cancers and distal pancreatectomy was performed. Pathological findings revealed microscopic cancer nests, which had connections to neither the main lesion nor the premalignant lesion in the pancreatic tail parenchyma. In both cases, the histological type of the daughter lesion was quite similar to that of the main lesion. Hence, we diagnosed the daughter lesions as metastatic foci in the pancreas. Although intrapancreatic metastasis of PDAC has been regarded as a poor prognostic factor, few reports of intrapancreatic metastasis are available. This article reports two such cases and provides a review of the literature.

关键词： Carcinoma pancreatic ductal Neoplasm micrometastasis Recurrence Carcinogenesis

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Role of epithelial-mesenchymal transition in chemoresistance in pancreatic ductal adenocarcinoma

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World Journal of Clinical Cases 2021年第19期9卷 4998-5006页

作者： Xiu Hu Wei Chen Department of Pharmacy Affiliated Hangzhou Cancer HospitalZhejiang University School of MedicineHangzhou 310002Zhejiang ProvinceChina Cancer Institute of Integrated Traditional Chinese and Western Medicine Key Laboratory of Cancer Prevention and Therapy Combining Traditional Chinese and Western Medicine of Zhejiang ProvinceZhejiang Academy of Traditional Chinese MedicineTongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina

pancreatic cancer(PC)is the seventh leading cause of cancer death *** vast majority of patients who have PC develop metastases,resulting in poor treatment *** great progress in therapeutic approaches has been achieved in recent decades,extensive drug resistance still persists,representing a major hurdle to effective anticancer therapy for pancreatic ductal adenocarcinoma(PDAC).Therefore,there is an urgent need to better understand the drug resistance mechanisms and develop novel treatment strategies to improve patient *** studies suggest that chemoresistance is closely related to epithelial-mesenchymal transition(EMT)of PDAC ***,this article summarizes the impact of EMT on PDAC from the perspective of chemotherapy resistance and discusses the possible novel applications of EMT inhibition to develop more effective drugs against PDAC.

关键词： Epithelial-mesenchymal transition Drug resistance Carcinoma pancreatic ductal Transcription factors MicroRNAs

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Value of diffusion-weighted imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis： a meta-analysis

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Chinese Medical Journal 2014年第19期127卷 3477-3482页

作者： Niu Xiangke Sushant Kumar Das Anup Bhetuwal Xiao Yingquan Sun Feng Zeng Lichuan Wang Wenxuan Yang Hanfeng Yang Hanyu Department of Radiology Affiliated Hospital of Chengdu UniversityChengdu Sichuan 610081 China Sichuan Key Laboratory of Medical Imaging and Department ofRadiology Affiliated Hospital of North Sichuan Medical CollegeNanchong Sichuan 637000 China Department of Oncology Sixth People's Hospital of ChengduChengdu Sichuan 610000 China

Background Several previous studies have shown that diffusion-weighted imaging （DWl） can provide additional information for focal pancreatic lesions by demonstrating more restricted diffusion in solid malignant tumors than in chronic pancreatitis, which can be indicated by a decreased apparent diffusion coefficient （ADC）. However, these studies have a modest sample size and convey inconclusive results. The aim of this study was to determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted magnetic resonance imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis. Methods We determined the sensitivities and specificities across studies. A summary receiver operator characteristic （sROC） curve was constructed to calculate the area under the curve （AUC）. Results The pooled sensitivity of DWI was 0.86 （95% Cl： 0.80-0.91） and the pooled specificity was 0.82 （95% CI： 0.72- 0.89）. The AUC of the sROC was 0.91 （95% CI： 0.88-0.93）. Conclusions DWl may be a potentially technically feasible tool for differentiating pancreatic carcinoma from mass- forming chronic pancreatitis. However, large-scale randomized control trials are necessary to assess its clinical value.

关键词： diffusion magnetic resonance imaging meta-analysis carcinoma pancreatic ductal pancreatitis chronic

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