Value of diffusion-weighted imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis： a meta-analysis

作     者：Niu Xiangke Sushant Kumar Das Anup Bhetuwal Xiao Yingquan Sun Feng Zeng Lichuan Wang Wenxuan Yang Hanfeng Yang Hanyu 

作者机构：Department of Radiology Affiliated Hospital of Chengdu UniversityChengdu Sichuan 610081 China Sichuan Key Laboratory of Medical Imaging and Department ofRadiology Affiliated Hospital of North Sichuan Medical CollegeNanchong Sichuan 637000 China Department of Oncology Sixth People's Hospital of ChengduChengdu Sichuan 610000 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2014年第127卷第19期

页      面：3477-3482页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100214[医学-肿瘤学] 10[医学] 

主　　题：diffusion magnetic resonance imaging meta-analysis carcinoma pancreatic ductal pancreatitis chronic 

摘      要：Background Several previous studies have shown that diffusion-weighted imaging （DWl） can provide additional information for focal pancreatic lesions by demonstrating more restricted diffusion in solid malignant tumors than in chronic pancreatitis, which can be indicated by a decreased apparent diffusion coefficient （ADC）. However, these studies have a modest sample size and convey inconclusive results. The aim of this study was to determine, in a meta-analysis, the diagnostic performance of quantitative diffusion-weighted magnetic resonance imaging in distinguishing pancreatic carcinoma from mass-forming chronic pancreatitis. Methods We determined the sensitivities and specificities across studies. A summary receiver operator characteristic （sROC） curve was constructed to calculate the area under the curve （AUC）. Results The pooled sensitivity of DWI was 0.86 （95% Cl： 0.80-0.91） and the pooled specificity was 0.82 （95% CI： 0.72- 0.89）. The AUC of the sROC was 0.91 （95% CI： 0.88-0.93）. Conclusions DWl may be a potentially technically feasible tool for differentiating pancreatic carcinoma from mass- forming chronic pancreatitis. However, large-scale randomized control trials are necessary to assess its clinical value.