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WW domain-containing protein genes identification in the silkworm and expansion in eukaryotes

WW domain-containing protein genes identification in the sil...

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中国蚕学会第八届青年学术研讨会

作者： Gang Meng Fang-Yin Dai Xiao-Ling Tong Nian-Nian Li Xin Ding Ping-Feng Liang Cheng Lu State Key Laboratory of Silkworm Genome Biology Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural Ministry Southwest University

WW domain-containing proteins（WWCPs） have been implicated in a variety of cellular processes, such as development,differentiation and cellular homeostasis, take critical roles in major human diseases including cancer as well as in major signaling cascades, making them targets for new diagnostics and therapeutics. Although there are a few studies on identification and function of WWCPs, it’s never having been systematically investigated in *** this study, by searching the silkworm genome assembly with the HMM model of WW domain（PF00397）, 24 proteins in the silkworm with 39 WW domains have been identified totally. Fifteen silkworm WW domain could be classified into Group I, another fifteen WW domains constituted the Group Ⅱ/Ⅲ（figure1b）, two WW Domains belong to the Group Ⅳ, and nine WW domain derived from eight silkworm WWCPs could not been classified into any group. The WWCPs of silkworm should take variety roles as RNA transcription and processing, cell apoptosis and differentiation, ubiquitination, control of the cytoskeleton and cell signal transduction based on the gene *** further analyzed the potential WWCP binding proteins in silkworm with regular expression of PPx Y motif（py motif） and poly-proline motif. We found that nearly eighteen percent of silkworm proteins contain PPx Y motif and thirty percent proteins totally in 14,623 predicted gene models of silkworm contain variety motifs that could be recognized/bond by WW domain potentially. GO analysis revealed that dozens of WW domain binding proteins we identified take part in Wnt, Hedgehog, Notch, m TOR, EGF and Jak-STAT signaling pathway besides the other various biology process include nutrient metabolism. The tissue expression patterns of WWCP genes and WWCP potential-binding protein genes on day 3 of the fifth instar were also examined by gene microarray analysis, and some of these genes shown tissue or sex-dependent expression pattern in ***, we identified and analyzed

关键词： Bombyx mori WW-domain containing protein py motif expression pattern metamorphism development

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Genome-wide analysis of the WW domain-containing protein genes in silkworm and their expansion in eukaryotes

Genome-wide analysis of the WW domain-containing protein gen...

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第十二届家（柞）蚕遗传育种暨良种繁育学术研讨会

作者： Gang Meng Fangyin Dai Xiaoling Tong Niannian Li Xin Ding Jiangbo Song Cheng Lu State Key Laboratory of Silkworm Genome Biology Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural Ministry Southwest University

WW domains are protein modules that mediate protein–protein interactions through recognition of proline-rich peptide motifs and phosphorylated serine/threonine–proline sites. WW domains are found in many different structural and signaling proteins that are involved in a variety of cellular processes. WW domain-containing proteins（WWCPs） and complexes have been implicated in major human diseases including cancer as well as in major signaling cascades such as the Hippo tumor suppressor pathway, making them targets for new diagnostics and therapeutics. There are a number of reports about the WWCPs in different species, but systematic analysis of the WWCP genes and its ligands is still lacking in silkworm and the other organisms. In this study, WWCP genes and py motif-containing proteins have been identified and analyzed in 56 species including silkworm. Whole-genome screening of B. mori identified thirty-three proteins with thirty-nine WW domains located on thirteen chromosomes. In the 39 silkworm WW domains, 15 domains belong to the Group I WW domain;14 domains were in Group II/III, 9 domains derived from 8 silkworm WWCPs could not be classified into any group, and Group IV contains only one WW domain. Based on gene annotation, silkworm WWCP genes have functions in multi-biology processes. A detailed list of WWCPs from the other 55 species was sorted in this work. In 14,623 silkworm predicted proteins, nearly 18 % contained py motif, nearly 30 % contained various motifs totally that could be recognized by WW domains. Gene Ontology and KEGG analysis revealed that dozens of WW domain-binding proteins are involved in Wnt, Hedgehog, Notch, m TOR, EGF and Jak-STAT signaling pathway. Tissue expression patterns of WWCP genes and potential WWCP-binding protein genes on the third day of the fifth instar（L5D3） were examined by microarray analysis. Tissue expression profile analysis found that several WWCP genes and poly-proline or py motif-containing protein genes took tissue-

关键词： WW domain-containing protein py motif Genome-wide analysis Expression pattern Bombyx mori

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