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Chinese Chemical Letters 2024年第3期35卷 352-357页

作者： Xuejian Xing E Pang Shaojing Zhao Tangna Pan Qiuxia Tan Benhua Wang Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China

Combining phototherapy and chemotherapy has been considered a promising modality for cancer therapy due to their synergistic ***,we developed three D-π-A-structured boron dipyrromethenes(BODIPYs)(named as B-B,B-C,and B-C-Pt).Due to their enlargedπ-conjugated structure and high intramolecular charge transfer effect,the synthesized BODIPYs had photothermal conversion capability,and their absorption and fluorescence spectra were *** cisplatin-appended BODIPY(B-C-Pt)exhibited good singlet oxygen(^1O_(2))generation ability and near infrared(NIR)absorption and fluorescence(λ_(Abs)=748 nm,λ_(Em)=947 nm).After being encapsulated by distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),which could inhibit the H-aggregation of B-C-Pt,the absorption and fluorescence of the obtained B-C-Pt nanoparticles(NPs)were red-shifted to 762 and 985 nm,***^1O_(2)quantum yield and photothermal conversion efficiency of the B-C-Pt NPs were 4.0%and 40.6%,***,B-C-Pt NPs had chemotherapeutic efficacy due to the presence of *** vitro and in vivo studies further demonstrated that B-C-Pt NPs had synergistic therapeutic ***,B-C-Pt NPs could be employed in NIRⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy for cancer treatment.

关键词： phototherapy Chemotherapy Cisplatin Bodipy NIRⅡfluorescent imaging

A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy

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Nano-Micro Letters 2022年第2期14卷 24-44页

作者： Xiaoge Zhang Lili Cheng Yao Lu Junjie Tang Qijun Lv Xiaomei Chen You Chen Jie Liu School of Biomedical Engineering Shenzhen Campus of Sun Yat-Sen UniversityNo.66Gongchang RoadGuangming DistrictShenzhenGuangdong 518107People’s Republic of China Department of General Surgery The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510006People’s Republic of China

The enzyme-mediated elevation of reactive oxygen species(ROS)at the tumor sites has become an emerging strategy for regulating intracellular redox status for anticancer ***,we proposed a camouflaged bionic cascaded-enzyme nanoreactor based on Ti_(3)C_(2)nanosheets for combined tumor enzyme dynamic therapy(EDT),phototherapy and deoxygenation-activated ***,glucose oxidase(GOX)and chloroperoxidase(CPO)were chemically conjugated onto Ti_(3)C_(2)nanosheets,where the deoxygenation-activated drug tirapazamine(TPZ)was also loaded,and the Ti_(3)C_(2)-GOX-CPO/TPZ(TGCT)was embedded into nanosized cancer cell-derived membrane vesicles with high-expressed CD47(m_eTGCT).Due to biomimetic membrane camouflage and CD47 overexpression,m_eTGCT exhibited superior immune escape and homologous targeting capacities,which could effectively enhance the tumor preferential targeting and *** internalized into tumor cells,the cascade reaction of GOX and CPO could generate HClO for efficient ***,additional laser irradiation could accelerate the enzymic-catalytic reaction rate and increase the generation of singlet oxygen(~1O_(2)).Furthermore,local hypoxia environment with the oxygen depletion by EDT would activate deoxygenation-sensitive prodrug for additional ***,m_eTGCT exhibits amplified synergistic therapeutic effects of tumor phototherapy,EDT and chemotherapy for efficient tumor *** intelligent cascaded-enzyme nanoreactor provides a promising approach to achieve concurrent and significant antitumor therapy.

关键词： Cascaded-enzyme nanoreactor Deoxygenation-sensitive prodrugs Tumor enzyme dynamic therapy phototherapy CD47

Recent Progress in Endoplasmic Reticulum-Targetable Small-Molecule Probes for Fluorescence Sensing and phototherapy

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Journal of Analysis and Testing 2023年第3期7卷 304-324页

作者： Jing Chen Huihong Liu Wenzhi Xie Maoxin Gu Guojiang Mao Sheng Yang Hunan Provincial Key Laboratory of Cytochemistry School of Chemistry and Chemical EngineeringChangsha University of Science and TechnologyChangsha 410114China Laboratory of Chemical Biology and Traditional Chinese Medicine Research(Ministry of Education) College of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Henan Key Laboratory of Organic Functional Molecule and Drug Innovation Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China

The endoplasmic reticulum(ER)is the most widespread organelle within eukaryotic cells,performing various essential functions such as protein synthesis,post-translational modifications,and lipid *** fluctuations of biologically active species and microenvironments in the ER can disrupt homeostasis and eventually lead to ER stress,which is closely linked to the occurrence and progression of many human ***,the ER has been regarded as an important analytical object as well as a promising therapeutic target in both bio sensing and ***,there has been a growing interest in developing photon-excited molecular tools to uncover the physio pathological roles of ER and treat ERrelated *** review presents a comprehensive summary of recent advances in ER-targeted small-molecule probes and their applications for fluorescent sensing and phototherapy,mainly focusing on targeting strategies and probe design ***,we discuss the challenges involved with ER-targeted probes and highlight potential prospects in this field.

关键词： Endoplasmic reticulum Organelle-targetable fl uorescent probe Subcellular analysis Endoplasmic reticulum stress phototherapy

Ursodeoxycholic acid as adjuvant treatment to phototherapy for neonatal hyperbilirubinemia:a systematic review and meta‑analysis

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World Journal of Pediatrics 2022年第9期18卷 589-597页

作者： Ilari Kuitunen Panu Kiviranta Ulla Sankilampi Marjo Renko Institute of Clinical Medicine Department of PediatricsUniversity of Eastern FinlandKuopioFinland Department of Pediatrics Mikkeli Central HospitalPorrassalmenkatu 35-3750100 MikkeliFinland Department of Pediatrics Kuopio University HospitalKuopioFinland

Background Neonatal hyperbilirubinemia is observed in most newborns,and 5–15%of neonates require *** is efective but often prolongs hospitalization and has both short-term and potential long-term *** aim of this systematic review and meta-analysis was to evaluate the role of ursodeoxycholic acid(UDCA)combined with phototherapy in neonatal *** A literature search was conducted on September 1,2021;590 studies were screened,and 17 full texts were assessed by two *** included randomized controlled trials with or without placebo *** outcomes were changes in total bilirubin levels at 24 hours and phototherapy *** calculated mean diferences with 95%confdence intervals(CI).Results Six studies with 880 neonates were *** these studies,only two used a placebo-controlled double-blinded *** overall risk of bias was high in one and moderate in four of the included *** mean decrease in the total bilirubin level during the frst 24 hours was 2.06 mg/dL(95%CI 0.82–3.30;six studies)greater in the UDCA treatment *** phototherapy duration was 19.7 hours(95%CI 10.4–29.1;fve studies)shorter in the UDCA treatment *** We found low-quality evidence that UDCA as an adjuvant to phototherapy seems to decrease total bilirubin faster and shorten phototherapy duration compared to standard *** studies are needed to confrm the efcacy,acute and long-term outcomes,and safety before implementing UDCA as an adjuvant to phototherapy in neonatal hyperbilirubinemia.

关键词： Jaundice phototherapy Unconjugated hyperbilirubinemia Ursodeoxycholic acid

Nanoparticles-based phototherapy systems for cancer treatment: Current status and clinical potential

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Bioactive Materials 2023年第5期23卷 471-507页

作者： Jiachen Li Shiqi Wang Flavia Fontana Christos Tapeinos Mohammad-Ali Shahbazi Huijie Han Helder A.Santos Department of Biomedical Engineering W.J.Kolff Institute for Biomedical Engineering and Materials ScienceUniversity Medical Center GroningenUniversity of GroningenAnt.Deusinglaan 1Groningen9713 AVthe Netherlands W.J.Kolff Institute for Biomedical Engineering and Materials Science University Medical Center GroningenUniversity of GroningenUniversity of GroningenAntonius Deusinglaan 19713 AVGroningenthe Netherlands Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of PharmacyUniversity of HelsinkiHelsinkiFI-00014Finland

Remarkable progress in phototherapy has been made in recent decades,due to its non-invasiveness and instant therapeutic *** addition,with the rapid development of nanoscience and nanotechnology,phototherapy systems based on nanoparticles or nanocomposites also evolved as an emerging hotspot in nanomedicine research,especially in *** this review,first we briefly introduce the history of phototherapy,and the mechanisms of phototherapy in cancer ***,we summarize the representative development over the past three to five years in nanoparticle-based phototherapy and highlight the design of the innovative nanoparticles ***,we discuss the feasibility and the potential of the nanoparticle-based phototherapy systems in clinical anticancer therapeutic applications,aiming to predict future research directions in this *** review is a tutorial work,aiming at providing useful insights to researchers in the field of nanotechnology,nanoscience and cancer.

关键词： phototherapy Cancer Nanoparticles Therapeutic effect Clinical potential

Black TiO_(2) nanoprobe-mediated mild phototherapy reduces intracellular lipid levels in atherosclerotic foam cells via cholesterol regulation pathways instead of apoptosis

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Bioactive Materials 2022年第11期7卷 18-28页

作者： Ting Dai Wenming He Shuangshuang Tu Jinru Han Bo Yuan Chenyang Yao Wenzhi Ren Aiguo Wu Department of Cardiology The Affiliated Hospital of Medical SchoolNingbo University247 Renmin RoadJiangbei DistrictNingboZhejiang Province315020China Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and Devices&Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of Sciences1219 ZhongGuan West RoadNingbo315201China University of Chinese Academy of Sciences No.1 Yanqihu East RoadHuairou DistrictBeijing101408China Advanced Energy Science and Technology Guangdong Laboratory Huizhou516000China

Given that apoptosis increases the risk of plaque rupture, strategies that reduce intracellular lipid levels without killing foam cells are warranted for safe and effective treatment of atherosclerosis. In this study, a mild pho-totherapy strategy is carried out to achieve the hypothesis. Foam cell-targeted nanoprobes that allow photo-thermal therapy (PTT) and/or photodynamic therapy (PDT) were prepared by loading hyaluronan and porphine onto black TiO_(2) nanoparticles. The results showed that when temperatures below 45 ◦C, PTT alone and PTT +PDT significantly reduced the intracellular lipid burden without inducing evidently apoptosis or necrosis. In contrast, the use of PDT alone resulted in only a slight reduction in lipid levels and induced massive apoptosis or necrosis. The protective effect against apoptosis or necrosis after mild-temperature PTT and PTT + PDT was correlated with the upregulation of heat shock protein 27. Further, mild-temperature PTT and PTT + PDT attenuated intracellular cholesterol biosynthesis and excess cholesterol uptake via the SREBP2/LDLR pathway, and also triggered ABCA1-mediated cholesterol efflux, ultimately inhibiting lipid accumulation in foam cells. Our results offer new insights into the mechanism of lipid regulation in foam cells and indicate that the black TiO_(2) nanoprobes could allow safer and more effective phototherapy of atherosclerosis.

关键词： Atherosclerosis Black TiO_(2)nanoparticles phototherapy Cholesterol homeostasis

Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to phototherapy to imaging

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Bioactive Materials 2022年第8期7卷 182-205页

作者： Hwa Seung Han Song Yi Koo Ki Young Choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health ***,they are a significant resource for drug discovery in the development of modern *** many BPCs have promising biological activities,most of them cannot be effectively utilized in drugs for therapeutic applications because of their inherent limitations of low solubility,structural instability,short half-life,poor bioavailability,and non-specific distribution to *** have utilized emerging nanoformulation(NF)technologies to overcome these limitations as they have demonstrated great potential to improve the solubility,stability,and pharmacokinetic and pharmacodynamic characteristics of *** review exemplifies NF strategies for resolving the issues associated with BPCs and summarizes recent advances in their preclinical and clinical applications for imaging and *** review also highlights how innovative NF technologies play a leading role in next-generation BPC-based drug development for extended therapeutic ***,this review discusses the opportunities to take BPCs with meaningful clinical impact from bench to bedside and extend the patent life of BPC-based medicines with new formulations or application to new adjacent diseases beyond the primary drug indications.

关键词： Natural products Phytocompound Nanoformulation Drug delivery phototherapy

Biomimetic biomineralization nanoplatform-mediated differentiation therapy and phototherapy for cancer stem cell inhibition and antitumor immunity activation

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Asian Journal of Pharmaceutical Sciences 2023年第5期18卷 164-184页

作者： Shan Gao Meng Liu Dongzhu Liu Xinru Kong Yuelin Fang Yingying Li Hang Wu Jianbo Ji Xiaoye Yang Guangxi Zhai Department of Pharmaceutics Key Laboratory of Chemical Biology(Ministry of Education)NMPA Key Laboratory for Technology Research and Evaluation of Drug ProductsSchool of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinanShandong250012China

Growing evidence suggests that the presence of cancer stem cells(CSCs)is a major challenge in current tumor treatments,especially the transition from non-CSCs to differentiation of CSCs for evading conventional therapies and driving *** we propose a therapeutic strategy of synergistic differentiation therapy and phototherapy to induce differentiation of CSCs into mature tumor cells by differentiation inducers and synergistic elimination of them and normal cancer cells through *** this work,we synthesized a biomimetic nanoplatform loaded with IR-780 and all-trans retinoic acid(ATRA)via *** method can integrate aluminum ions into small-sized protein carriers to form nanoclusters,which undergo responsive degradation under acidic conditions and facilitate deep tumor *** the help of CSC differentiation induced by ATRA,IR-780 inhibited the self-renewal of CSCs and cancer progression by generating hyperthermia and reactive oxygen species in a synergistic ***,ATRA can boost immunogenic cell death induced by phototherapy,thereby strongly causing a systemic anti-tumor immune response and efficiently eliminating CSCs and tumor *** together,this dual strategy represents a new paradigm of targeted eradication of CSCs and tumors by inducing CSC differentiation,improving photothermal therapy/photodynamic therapy and enhancing antitumor immunity.

关键词： Cancer stem cells Differentiation therapy phototherapy Biomineralization Immunogenic cell death

Emerging Designs of Aggregation-Induced Emission Agents for Enhanced phototherapy Applications

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CCS Chemistry 2022年第2期4卷 401-419页

作者： Rui Qu Xu Zhen Xiqun Jiang MOE Key Laboratory of High Performance Polymer Materials and Technology Department of Polymer Science&EngineeringCollege of Chemistry&Chemical EngineeringNanjing UniversityNanjing 210093

phototherapy,including photodynamic therapy(PDT)and photothermal therapy(PTT),that employs phototherapeutic agents to generate cytotoxic reactive oxygen species(ROS)or hyperthermia,is a promising approach for disease ***,conventional organic phototherapeutic agents suffer poor photostability and aggregation-caused quenching(ACQ)in the aggregate state,restricting their therapeutic ***-induced emission(AIE)agents can solve these issues with strong emission in the aggregate state and reverse designation to generate *** review summarizes the recent advances in the development of AIE phototherapy agents for enhanced PDT and PTT performances in biomedical ***,design strategies of AIE agents that adjust the intersystem crossing process or intramolecular charge transfer to boost ROS generation or regulate ROS types are *** AIE agents with ROS generation ability for biomedical applications including antitumor and antibacterial performances are then ***,designs and examples of AIE agents that enhance PTT performances through molecular motions are ***,the current challenges and perspectives of AIE agents in the phototherapy field are discussed.

关键词： aggregation-induced emission structural designing phototherapy photodynamic therapy photothermal therapy

phototherapy FOR MILD TO MODERATE ACNE VULGARIS WITH PORTABLE BLUE AND RED LED

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Journal of Innovative Optical Health Sciences 2011年第1期4卷 45-52页

作者： GUANGDA LIU CHANGE PAN KAI LI YUAN TAN XUNBIN WEI Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China Shanghai Medical School Fudan UniversityShanghai 200032China School of Life Sciences Fudan UniversityShanghai 200032China Department of Chemistry Fudan UniversityShanghai 200032China Cancer Hospital Fudan UniversityShanghai 200032China

In this paper,we studied portable blue and red light-emitting-diode(LED)light sources in phototherapy for mild to moderate acne vulgaris to evaluate the efficacy and tolerance of ***,randomly divided into blue and red groups,received either blue or red LED phototherapy twice a week for four *** complete treatment,the number of lesions reduced by 71.4% in the blue group,in contrast to 19.5% in the red *** obvious side effects were observed during and one month after the treatment,except for some mild dryness mentioned by several patients.

关键词： Acne vulgaris light emitting diode phototherapy portable light sources