Ursodeoxycholic acid as adjuvant treatment to phototherapy for neonatal hyperbilirubinemia:a systematic review and meta‑analysis

作     者：Ilari Kuitunen Panu Kiviranta Ulla Sankilampi Marjo Renko Ilari Kuitunen;Panu Kiviranta;Ulla Sankilampi;Marjo Renko

作者机构：Institute of Clinical MedicineDepartment of PediatricsUniversity of Eastern FinlandKuopioFinland Department of PediatricsMikkeli Central HospitalPorrassalmenkatu 35-3750100 MikkeliFinland Department of PediatricsKuopio University HospitalKuopioFinland 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2022年第18卷第9期

页      面：589-597页

核心收录：

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

基　　金：Open access funding provided by University of Eastern Finland(UEF)including Kuopio University Hospital 

主　　题：Jaundice Phototherapy Unconjugated hyperbilirubinemia Ursodeoxycholic acid 

摘      要：Background Neonatal hyperbilirubinemia is observed in most newborns,and 5–15%of neonates require *** is efective but often prolongs hospitalization and has both short-term and potential long-term *** aim of this systematic review and meta-analysis was to evaluate the role of ursodeoxycholic acid(UDCA)combined with phototherapy in neonatal *** A literature search was conducted on September 1,2021;590 studies were screened,and 17 full texts were assessed by two *** included randomized controlled trials with or without placebo *** outcomes were changes in total bilirubin levels at 24 hours and phototherapy *** calculated mean diferences with 95%confdence intervals(CI).Results Six studies with 880 neonates were *** these studies,only two used a placebo-controlled double-blinded *** overall risk of bias was high in one and moderate in four of the included *** mean decrease in the total bilirubin level during the frst 24 hours was 2.06 mg/dL(95%CI 0.82–3.30;six studies)greater in the UDCA treatment *** phototherapy duration was 19.7 hours(95%CI 10.4–29.1;fve studies)shorter in the UDCA treatment *** We found low-quality evidence that UDCA as an adjuvant to phototherapy seems to decrease total bilirubin faster and shorten phototherapy duration compared to standard *** studies are needed to confrm the efcacy,acute and long-term outcomes,and safety before implementing UDCA as an adjuvant to phototherapy in neonatal hyperbilirubinemia.