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Evaluation of the anti-dyslipidemic effect of spice fixed oils in the in vitro assays and the high fat diet-induced dyslipidemic mice

引用

Food Bioscience 2022年第2期46卷 647-657页

作者： Vallamkondu Manasa Ajay W.Tumaney Academy of Scientific and Innovative Research(AcSIR) Ghaziabad201002India Department of Lipid Science Council of Scientific and Industrial Research-Central Food Technological Research InstituteMysore570020India

Dyslipidemia is a condition in which the lipid levels are altered in the *** fixed oils(FOs)from spices,Alpinia galanga,Cinnamomum zeylanicum,Trigonella foenum-graecum,Foeniculum vulgare,and Myristica fragrans were evaluated as potential sources of anti-dyslipidemic *** nutraceutical compound fractions such as polyphenols,tocopherols,γ-oryzanol,and phytosterols were extracted from spice FOs,tested individually and in combination for cytotoxicity and their effect on lipid accumulation in 3T3-L1 and Hep-G2 cell ***,the best performing FOs in the in vitro studies were fed to high fat diet-induced dyslipidemic C57BL/6 mice and studied its activity in the liver and adipose *** in vitro assays showed no cytotoxicity in the studied FOs up to 200μg/mL *** of all the studied nutraceutical compound fractions,theγ-oryzanol and phytosterols fractions showed a reduction in the accumulation of lipid droplets in 3T3-L1 cell ***,the reconstituted nutraceutical fractions from ***,***-graecum,and *** FOs exhibited a dose dependent inhibition of lipid accumulation compared to the fractions of *** and *** *** in vivo studies confirmed the anti-dyslipidemic activity of *** FO that showed an improved lipid profile,antioxidant enzymes,and reduced lipid droplets in the liver and adipose *** histopathological images of the liver and adipose tissue showed a comparable visualisation in Atorvastatin,and *** fed group ***,the spice FOs are potentially efficacious anti-dyslipidemic functional food ingredients and could be safer than statins.

关键词： Spice fixed oils γ-Oryzanol Anti-dyslipidemic activity C57BL/6 oxidative stress markers

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