Evaluation of the anti-dyslipidemic effect of spice fixed oils in the in vitro assays and the high fat diet-induced dyslipidemic mice
作者机构：Academy of Scientific and Innovative Research(AcSIR)Ghaziabad201002India Department of Lipid ScienceCouncil of Scientific and Industrial Research-Central Food Technological Research InstituteMysore570020India
出 版 物：《Food Bioscience》 (食品生物科学（英文）)
年 卷 期：2022年第46卷第2期
页 面：647-657页
核心收录：
学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：The author(VM)is thankful to the Indian Council of Medical Research New Delhi India for the award of ICMR-SRF.The authors greatly acknowledge the Director CSIR-CFTRI for her constant support and encouragement.Part of this work was supported by SERB New Delhi(ECR/2016/001548) India
主 题：Spice fixed oils γ-Oryzanol Anti-dyslipidemic activity C57BL/6 Oxidative stress markers
摘 要：Dyslipidemia is a condition in which the lipid levels are altered in the *** fixed oils(FOs)from spices,Alpinia galanga,Cinnamomum zeylanicum,Trigonella foenum-graecum,Foeniculum vulgare,and Myristica fragrans were evaluated as potential sources of anti-dyslipidemic *** nutraceutical compound fractions such as polyphenols,tocopherols,γ-oryzanol,and phytosterols were extracted from spice FOs,tested individually and in combination for cytotoxicity and their effect on lipid accumulation in 3T3-L1 and Hep-G2 cell ***,the best performing FOs in the in vitro studies were fed to high fat diet-induced dyslipidemic C57BL/6 mice and studied its activity in the liver and adipose *** in vitro assays showed no cytotoxicity in the studied FOs up to 200μg/mL *** of all the studied nutraceutical compound fractions,theγ-oryzanol and phytosterols fractions showed a reduction in the accumulation of lipid droplets in 3T3-L1 cell ***,the reconstituted nutraceutical fractions from ***,***-graecum,and *** FOs exhibited a dose dependent inhibition of lipid accumulation compared to the fractions of *** and *** *** in vivo studies confirmed the anti-dyslipidemic activity of *** FO that showed an improved lipid profile,antioxidant enzymes,and reduced lipid droplets in the liver and adipose *** histopathological images of the liver and adipose tissue showed a comparable visualisation in Atorvastatin,and *** fed group ***,the spice FOs are potentially efficacious anti-dyslipidemic functional food ingredients and could be safer than statins.
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