检索结果-南通市图书馆

Brazilian vaccinia virus strains show a classical Orthopoxvirus infection course and cross-protection

Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 21-26页

作者： Jaqueline Maria Siqueira Ferreira Betnia Paiva Drumond J?natas Santos Abraho Zélia Inês Portela Lobato Cláudio Ant?nio Bonjardim Paulo César Peregrino Ferreira Erna Geessien Kroon Laboratorio de Virus Departamento de MicrobiologiaInstituto de Ciencias Biologicas Departamento de Medicina Veterinaria Preventiva Escola de VeterindriaUniversidade Federal de Minas Gerais.Avenida Antonio Carlos6627caixa postal 486CEP 31270-901 Belo HorizonteMGBrazil

Objectives:The purpose of this work was to study the infection course and cross-protection in mice after intradermal injection of Vaccinia virus(VACV) strain Western Reserve and three Brazilian VACV strains: Aracatuba,Muriae and BeAn58058 isolated from cow,human and rodent,respectively.Methods:Balb/c mice were inoculated by footpad and back scarification and daily monitored regarding lesion development and weight loss.To check cross protection after intradermal VACV inoculation,mice were subsequendy infected with different VACV strains and monitored to check lesion development.Serum neutralization assays were performed to check for the presence of antibodies against Orthopoxvirus.Results:After VACV intradermal inoculation the lesion development pattern was similar in mice infected with the different virus strains.By using the footpad scarification model,cross-protection among VACV strains was observed.Moreover,neutralizing antibodies against Orthopoxvirus were detected in sera from mice infected with all VACV strains.Conclusion:Although it was not possible to observe virulence differences among VACV strains isolated from cow,rodent and human using the murine model,this inoculation route showed to be an appropriated model to study lesions development since it mimics natural infections by VACV in nature.

关键词： Orthopoxvirus Zoonoses Balb/c mice Intradermal injection Vaccinia virus Bovine vaccinia outbreaks

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Monkeypox virus:past and present

引用

World Journal of Pediatrics 2023年第3期19卷 224-230页

作者： Ya-Mei Dou Hang Yuan Hou-Wen Tian NHC Key Laboratory of Medical Virology and Viral Disease Chinese Center for Disease Control and PreventionNational Institute for Viral Disease Control and Prevention155 Changbai RoadChangPing DistrictBeijing 102206China

Background The objective of this paper is to analyze the current status of monkeypox worldwide.In the face of this public health threat,our purpose is to elucidate the clinical characteristics and epidemiology of monkeypox,the developmental progress of monkeypox-related drugs and the vaccines available.Data sources The literature review was performed in databases including PubMed,Science Direct and Google Scholar up to July 2022.Results Since May 2022,the World Health Organization has reported more than 45,000 confirmed cases from 92 nonendemic countries,including nine deaths.Although some women and children have been infected so far,most cases have occurred among men who have sex with other men,especially those with multiple sexual partners or anonymous sex.Conclusions Pediatric monkeypox infection has been associated with a higher likelihood of severe illness and mortality than in adults.Severe monkeypox illness in pediatrics often requires adjunctive antiviral therapy.It is crucial for all countries to establish sound monitoring and testing systems and be prepared with emergency preparedness.

关键词： Monkeypox Orthopoxvirus Smallpox Zoonotic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Monkeypox virus:a re-emergent threat to humans

引用

Virologica Sinica 2022年第4期37卷 477-482页

作者： Qizan Gong Changle Wang Xia Chuai Sandra Chiu Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei230026China Department of Pathogenic Biology Hebei Medical UniversityShijiazhuangHebei050017China

Human monkeypox(MPX)is a rare zoonotic infection characterized by smallpox-like signs and symptoms.It is caused by monkeypox virus(MPXV),a double stranded DNA virus belonging to the genus Orthopoxvirus.MPX was first identified in 1970 and mostly prevailed in the rural rainforests of Central and West Africa in the past.Outside Africa,MPX was reported in the United Kingdom,the USA,Israel,and Singapore.In 2022,the resurgence of MPX in Europe and elsewhere posed a potential threat to humans.MPXV was transmitted by the animals-human or human-human pathway,and the symptoms of MPXV infection are similar to that of smallpox,but in a milder form and with lower mortality(1%–10%).Although the smallpox vaccination has been shown to provide 85%protection against MPXV infection,and two anti-smallpox virus drugs have been approved to treat MPXV,there are still no specific vaccines and drugs against MPXV infection.Therefore it is urgent to take active measures including the adoption of novel anti-MPXV strategies to control the spread of MPXV and prevent MPX epidemic.In this review,we summarize the biological features,epidemiology,pathogenicity,laboratory diagnosis,and prevention and treatment strategies on MPXV.This review provides the basic knowledge for prevention and control of future outbreaks of this emerging infection.

关键词： Monkeypox virus(MPXV) Orthopoxvirus Smallpox vaccine Antiviral drugs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Monkeypox:A comprehensive review of a multifaceted virus

引用

Infectious Medicine 2023年第2期2卷 74-88页

作者： Randa Elsheikh Abdelrahman M.Makram Tamilarasy Vasanthakumaran Shubham Tomar Khizer Shamim Nguyen Dong Tranh Sara S.Elsheikh Nguyen Thanh Van Nguyen Tien Huy Deanery of Biomedical Sciences at Edinburgh Medical School University of EdinburghEdinburgh EH105HFUnited Kingdom Online Research Club(http://***) Nagasaki 852-8523Japan School of Public Health Imperial College LondonLondon SW72BXUnited Kingdom Global Clinical Scholars Research Training Harvard Medical SchoolBostonMA 02115USA Tata Memorial Hospital Varanasi 400012India DataQ Health Karachi 75100Pakistan Department of Infection Control Binh Dinh Provincial General HospitalBinh Dinh 55000Vietnam Faculty of Medicine Zagazig UniversityZagazig 44519Egypt School of Tropical Medicine and Global Health Nagasaki UniversityNagasaki 852-8523Japan

In May 2022,the world witnessed the re-emergence of the zoonotic disease monkeypox.While this was not the first epidemic of this disease,what differentiated the outbreak was the rapid global spread and increase of cases,which led the WHO to declare monkeypox a global health emergency.Although the disease spreads mainly through inadequately cooked meat of various rodent species,this virus also shows droplet,respiratory,sexual,and even vertical transmission.Monkeypox further multiplies in lymphoproliferative organs and presents with a classical smallpox-like rash,fever,headache,and muscle aches.Diagnosis is confirmed with a polymerase-chain-reaction test and is managed largely supportively with possible usage of some antivirals and immunoglobulins.Moreover,some pre-exposure and postexposure prophylactic vaccines have been developed.This paper aims to conduct an in-depth review of the historical epidemics,transmission,pathophysiology,clinical presentation,and management of the monkeypox disease.

关键词： Monkeypox Orthopoxvirus Outbreak Smallpox

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of the diagnostic performance of a commercial molecular assay for the screening of suspected monkeypox cases in Sri Lanka

引用

Infectious Medicine 2023年第2期2卷 136-142页

作者： H.B.C.Harshani G.A.Liyanage D.V.R.G.Ruwan U.K.I.U.Samaraweera J.I.Abeynayake Medical Research Institute Colombo 08Sri Lanka

Background:The main objective of the present study was to compare the diagnostic performance of the commercial LightMix Modular Monkeypox Virus(MPXV)qPCR(TIB Molbiol,Germany)assay with the in-house non-variola orthopox/monkeypox generic real-time PCR assay(ICMR-NIV,Pune)for the screening of(MPXV)cases at Medical Research Institute(MRI)in Sri Lanka.Furthermore,clinical and sociodemographic data of suspected/confirmed cases received at MRI for the MPXV screening were also analyzed.Methods:The diagnostic performance of the commercial LightMix Modular MPXV qPCR assay with the in-house nonvariola orthopox/monkeypox generic real-time PCR assay for the screening of suspected MXPV cases was evaluated using standard methods with minor modifications.Socio-demographic and clinical profiles of suspected and confirmed MPXV cases were also analyzed.Results:The commercial LightMix Modular MPXV assay was able to detect MPXV with 100%sensitivity and specificity with non-variola orthopox/monkeypox generic rtPCR assay.During the period of study,from the total of 25 samples tested,only 2 were MPXV-positive(males).The most common symptoms of suspected MPXV cases were lesions or rashes(92%).Conclusions:With the continually increasing number of cases,access to MPXV testing should be made more widely available.The commercial LightMix Modular MPXV(TIB Molbiol)qPCR assay offers comparable performance to the non-variola orthopox/monkeypox generic real time PCR assay for MPXV detection during the present outbreak.

关键词： Orthopoxvirus Monkeypox virus Real-time PCR assays Patient screening

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Review of the prevalence,diagnostics,and containment measures of the current mpox outbreak

引用

World Journal of Clinical Cases 2023年第6期11卷 1252-1260页

作者： Adekunle Sanyaolu Aleksandra Marinkovic Chuku Okorie Stephanie Prakash Nafees Haider Yashika Dixon Ricardo Izurieta Olanrewaju Badaru Stella Smith Public Health Federal Ministry of HealthAbuja 083Federal Capital TerritoryNigeria Basic Science Saint James School of MedicineThe Quarter 2640Anguilla Allied Sciences Union County CollegePlainfieldNJ 07060United States Basic Science All Saints University School of MedicineRoseau 0000Dominica Basic Science Windsor University School of MedicineCayon 0000Saint Kitts and Nevis Global Communicable Diseases College of Public HealthUniversity of South FloridaTampaFL 33620United States Department of Molecular Biology and Biotechnology Nigerian Institute of Medical ResearchLagos 101245Nigeria

Monkeypox(mpox),is a disease from the Poxviridae family that can cause several serious medical issues.This mini-review sought to analyze the existing literature regarding the current mpox outbreak with a focus on the prevalence,diagnostics,and containment measures.Mpox cases have been reported to World Health Organization(WHO)from 85 Member States in all six WHO regions during the period of January 1,2022,through August 3,2022.Standardized or optimized guidelines for the clinical care of patients with mpox are limited,particularly in low-resource settings.In an effort to achieve guidance and meet standards,special attention should be paid to this outbreak in order to eradicate such a rare infectious disease by analyzing prevention and control measures.Patient outcomes may also be poor,and their illnesses may last for a long time.The spectrum of clinical symptoms,including complications and sequelae,as well as aspects of the illness may be indicators of sickness severity and complications;therefore,its clinical presentation must be better understood to improve containment measures.In addition,it is important to create and evaluate a standard of care that takes a variety of parameters into account,including antiviral,immune therapies,and clinical metrics that are particular to mpox.The global emergence of mpox has presented new challenges for public health and has called for further investigation into its epidemiological profile across international contexts.

关键词： Monkeypox virus Outbreak Prevalence Containment Epidemiology Orthopoxvirus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：