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Engineering 2024年第1期32卷 29-40页

作者： Zhoucheng Wang Jack Martin Jiongjie Yu Kai Wang Kourosh Saeb-Parsy Xiao Xu Zhejiang University School of Medicine Hangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Hangzhou 310006China Department of Surgery Cambridge University Hospitals&NHS Foundation TrustCambridge CB22QQ UK Department of Surgery University of Cambridge&NIHR Cambridge Biomedical Research CentreCambridge CB22QQUK Institute of organ Transplantation Zhejiang UniversityHangzhou 310003China

Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor *** criteria donor(ECD)liver grafts are increasingly utilized in clinical practice to mitigate this ***,impaired ischemic tolerance of these grafts jeopardizes organ viability during cold *** perfusion(MP)was designed to improve organ preservation and reduce posttransplant ***,it is increasingly evident that MP alone may not preserve ECD grafts *** emphasis has thus been placed on modified MP strategies,including the use of different perfusates,modified perfusion modalities,and different therapeutic ***,we introduce a novel term,"MP Plus,"denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of ECD *** this review,we summarize the existing and potential modified MP strategies and discuss their advantages in reconditioning different ECD grafts in clinical settings.

关键词： Liver transplantation Extended criteria donor Machine perfusion plus organ shortage

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Liver transplantation for non-resectable colorectal metastases-an evolving paradigm in transplant oncology

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 424-427页

作者： Christian Hobeika Markus Selzner Ajmera Transplant Centre Toronto General HospitalUniversity Health NetworkTorontoONCanada Department of HPB Surgery and Liver Transplantation Beaujon HospitalAPHPClichyParis-CitéUniversityParisFrance UMR Inserm 1275 CAP Paris-Tech Lariboisière HospitalParisParis-CitéUniversityParisFrance Department of Surgery University of TorontoTorontoONCanada

A better understanding of colorectal liver metastasis(CRLM)onco-genomics and the improvement of systemic treatments,including targeted and immune therapies,have shifted the paradigm of CRLM prognosis over the past two *** 40%of the patients with colorectal cancers are likely to develop CRLM[and 50%of them to be non-resectable(nCRLM)],current oncologic management allows for the identification of a subset of CRLM patients with controlled diseases likely to highly benefit from curative resections and,perhaps,liver transplantation(LT).Indeed,the Norwegian SECA I trial in 2013(1)triggered a growing interest in LT as a curative treatment for non-resectable colorectal liver metastasis(nCRLM).This strategy is supported by several pilot studies reporting up to 80%of 5-year estimated overall survival(OS)after LT for CRLM,in contrast to the poor results obtained in the early 80’s series.

关键词： Colorectal cancer liver metastasis transplant oncology guidlines liver transplantation(LT) organ shortage living donor

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