“机械灌注+”应用于扩大标准供肝移植--肝尽其用

作     者：Zhoucheng Wang Jack Martin Jiongjie Yu Kai Wang Kourosh Saeb-Parsy Xiao Xu Zhoucheng Wang;Jack Martin;Jiongjie Yu;Kai Wang;Kourosh Saeb-Parsy;Xiao Xu

作者机构：Zhejiang University School of MedicineHangzhou 310058China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang ProvinceHangzhou 310006China Department of SurgeryCambridge University Hospitals&NHS Foundation TrustCambridge CB22QQ UK Department of SurgeryUniversity of Cambridge&NIHR Cambridge Biomedical Research CentreCambridge CB22QQUK Institute of Organ TransplantationZhejiang UniversityHangzhou 310003China 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2024年第32卷第1期

页      面：29-40页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：the National Key Research and Development Program of China(2021YFA1100500) the Zhejiang University-Cambridge Global Partnership Fund the National Natural Science Foundation of China(81930016 and 82003248) the Key Research and Development Program of Zhejiang Province(2022C03108) the Projects of Medical and Health Technology Program in Zhejiang Province(WKJZJ-2120) 

主　　题：Liver transplantation Extended criteria donor Machine perfusion plus Organ shortage 

摘      要：Transplantation represents the most effective treatment for end-stage liver diseases but is limited by the shortage of healthy donor *** criteria donor(ECD)liver grafts are increasingly utilized in clinical practice to mitigate this ***,impaired ischemic tolerance of these grafts jeopardizes organ viability during cold *** perfusion(MP)was designed to improve organ preservation and reduce posttransplant ***,it is increasingly evident that MP alone may not preserve ECD grafts *** emphasis has thus been placed on modified MP strategies,including the use of different perfusates,modified perfusion modalities,and different therapeutic ***,we introduce a novel term,MP Plus,denoting these additional strategies that are designed to restore organ function and potentially enable regeneration of ECD *** this review,we summarize the existing and potential modified MP strategies and discuss their advantages in reconditioning different ECD grafts in clinical settings.