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The clinical effectiveness of reflectance optical spectroscopy for the in vivo diagnosis of oral lesions

International Journal of oral Science 2014年第3期6卷 162-167页

作者： Diana V Messadi Fariba S Younai Hong-Hu Liu Gao Guo Cun-Yu Wang Section of oral Medicine and Orofacial Pain Division of Oral Biology and Medicine School of Dentistry University of California at Los Angeles Section of oral Biology Division of Oral Biology and Medicine School of Dentistry University of California at Los Angeles Division of Public Health and Community Dentistry School of Dentistry University of California at Los Angeles David Geffen School of Medicine and Fielding School of Public Health

Optical spectroscopy devices are being developed and tested for the screening and diagnosis of oral precancer and cancer lesions. This study reports a device that uses white light for detection of suspicious lesions and green–amber light at 545 nm that detect tissue vascularity on patients with several suspicious oral lesions. The clinical grading of vascularity was compared to the histological grading of the biopsied lesions using specific biomarkers. Such a device, in the hands of dentists and other health professionals, could greatly increase the number of oral cancerous lesions detected in early phase. The purpose of this study is to correlate the clinical grading of tissue vascularity in several oral suspicious lesions using the IdentafiH system with the histological grading of the biopsied lesions using specific vascular markers. Twenty-one patients with various oral lesions were enrolled in the study. The lesions were visualized using IdentafiH device with white light illumination, followed by visualization of tissue autofluorescence and tissue reflectance. Tissue biopsied was obtained from the all lesions and both histopathological and immunohistochemical studies using a vascular endothelial biomarker（CD34） were performed on these tissue samples. The clinical vascular grading using the green–amber light at 545 nm and the expression pattern and intensity of staining for CD34 in the different biopsies varied depending on lesions, grading ranged from 1 to3. The increase in vascularity was observed in abnormal tissues when compared to normal mucosa, but this increase was not limited to carcinoma only as hyperkeratosis and other oral diseases, such as lichen planus, also showed increase in vascularity. Optical spectroscopy is a promising technology for the detection of oral mucosal abnormalities; however, further investigations with a larger population group is required to evaluate the usefulness of these devices in differentiating benign lesions from potentially

关键词： ansiosenesis optical spectroscopy oral lesions

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Concomitant-chemoradiotherapy-associated oral lesions in patients with oral squamous-cell carcinoma

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Cancer Biology & Medicine 2017年第2期14卷 176-182页

作者： Sadia Minhas Muhammad Kashif Wasif Altaf Nadeem Afzal Abdul Hanan Nagi oral Pathology Department Akhtar Saeed Medical and Dental College Immunology Department University of Health SciencesPunjab Dentistry Department Fauji Foundation Hospital Morbid Anatomy and Histopathology Department University of Health SciencesPunjab

Objective:oral squamous-cell carcinoma(OSCC)accounts for >90% of oral cancers affecting adults mostly between the fourth to seventh decades of *** most common OSCC treatment is concomitant chemoradiotherapy(CCRT)having both locoregional and distant control,but CCRT has acute and chronic toxic effects on adjacent normal *** study aimed to determine the side effects of CCRT on the oral mucosa and to characterize the clinicopathology of oral lesions in patients with ***:This descriptive,cross-sectional study was certified by the Ethical Review Committee(UHS/Education/126-12/2728)of the University of Health Sciences,Lahore,*** patients(n=81)with various histological subtypes,grades,and stages were recruited,and findings on their oral examination were *** patients received 70,90,and 119 Gy of radiotherapy dosages in combination with the chemotherapy drugs cisplatin and *** were analyzed using SPSS ***:The most common presentation of OSCC was a nonhealing ulcer(63%) involving tongue(55.6%).Clinical findings included mucositis(92.6%)and xerostomia of mild,moderate,and severe degrees in 11.1%,46.9%,and 35.8% cases,***(87.7%),palpable lymph nodes(64.2%),limited mouth opening(64.2%)and fistula(40.7%) were also *** females,the association of radiotherapy dosage with limited mouth opening,xerostomia,and histological grading was statistically significant(P<0.05).The association of chemotherapy drugs with xerostomia(P=0.003)was also statistically ***:CCRT induced mucositis,xerostomia,and trismus in patients with OSCC.

关键词： OSCC CCRT oral lesions xerostomia trismus

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oral lesions Observed in Tobacco Consumers: Socio-Demographical and Clinical Aspects in the Prefectures of Kankan and Siguiri Republic of Guinea

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Open Journal of Stomatology 2021年第11期11卷 443-450页

作者： Diallo Oumar Raphiou Conde Alhassane Diallo Ibrahim Balde Mamadou Aliou Department of Odontostomatology and Maxillofacial Surgery Donka National Hospital Conakry Guinea Center for Research and Valorization of Medicinal Plants Conakry Guinea

Introduction: oral lesions observed in Chewing Tobacco (CT) consumers are histological alterations caused by direct contact with the tissues of the oral cavity. The objectives of this study were to determine the socio-demographic status of consumers and describe the clinical characteristics of the oral lesions observed. Material and Method: It was a descriptive cross-sectional study lasting 12 months (January 2017 to January 2018), in the prefectures of Kankan and Siguiri as a framework. Individuals who use chewing tobacco and whose oral examination revealed oral lesions were included in this study. Results: The frequency of oral lesions induced by the consumption of chewing tobacco was 90%. Dental pain was the most cited reason for using CT by respondents, i.e., 25.41%. The most concerned age group was that of 50 - 64 years or 23.81 with a male predominance of 84.13% (n = 53). A number of 61 respondents came from rural areas. Farmers were the predominant socio-professional group, i.e., 63.49% (n = 40). In 60.32% (n = 38) of respondents, the duration of CT consumption was greater than 10 years. Black villous tongues followed by neoplastic ulcerations were the most common oral lesions with 32 (50.79%) and 14 (22.22%) cases, respectively. The site of the lesion was the tongue in 47 consumers (74.61%) and in the lower vestibule in 15 users (23.80%). Among the oral diseases, mylolysis was the most common, i.e., 95.24% (n = 60). In 82.54% of cases (n = 52), Simplified oral Hygiene Index (SOHI) was low and in 12.70% (n = 8) of respondents, SOHI was good. Conclusion: Chewing tobacco predisposes to a high risk of damage to the oral cavity and the development of potentially malignant lesions. In addition, it exerts some detrimental effects on the teeth and adjacent structures.

关键词： Chewing Tobacco oral lesions Socio-demographic Clinical Guinea

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The Prevalence of oral lesions among Palestinian Dental Patients Attending oral Medicine Dental Clinics at Al-Quds University

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Open Journal of Stomatology 2020年第10期10卷 300-309页

作者： F. S. Habash A. Ismail R. O. Abu Hantash M. Abu Younis Faculty of Dentistry Al-Quds University Jerusalem Palestine

Objectives: In Palestine, there are no data about the prevalence of oral lesions or their associated risk factors. Thus, this study came to assess the prevalence and the risk factors of oral lesions among adult dental patients visiting Al-Quds University (AQU) Dental Clinics. Materials and Methods: Three hundred Twenty patients were diagnosed clinically for the presence of oral lesions at oral medicine clinics at Al-Quds University in the period between 2015 to 2016. Their age ranged from 21 to 60 years old (mean age: 40.2 ± 17.6). Senior students were trained to conduct the oral exam under the direct supervision of oral Medicine specialist. Trained students also collected data on patients’ demographics, dental history, medical history and other health related habits. Descriptive and bivariate analyses were generated to describe lesions prevalence and associations with other suggested factors. Results: A total of 68 lesions were found in this study (29.4% of study’s sample). Recurrent aphthous ulcer, traumatic ulcer and geographic tongue were the most common oral lesions. Ten oral potentially malignant lesions were diagnosed (8 cases were Leukoplakia, 2 cases were erythroplakia). Non filtered smoking cigarettes were associated with reported lesions. oral lesions were noticed to increase with age. oral lesions were more common on the Tongue, labial and buccal mucosain this study. Conclusions: This study revealed high prevalence of apthous and traumatic ulcer while potentially malignant lesions like leucoplakia and erythroplakia were also seen in patients who were smokers. Dentists should have a high level of awareness during oral examination and intervention should be performed to raise awareness among the population about the harmful effects of smoking on oral health.

关键词： oral lesions Potentially Malignant Smoking Habits

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Review of oral and pharyngolaryngeal benign lesions detected during esophagogastroduodenoscopy

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World Journal of Gastrointestinal Endoscopy 2023年第7期15卷 496-509页

作者： Masaya Iwamuro Kenta Hamada Seiji Kawano Yoshiro Kawahara Motoyuki Otsuka Department of Gastroenterology and Hepatology Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan Department of Practical Gastrointestinal Endoscopy Okayama University Graduate School of MedicineDentistryand Pharmaceutical SciencesOkayama 700-8558Japan

Recent advancements in endoscopy equipment have facilitated endoscopists’detection of neoplasms in the oral cavity and pharyngolaryngeal *** particular,image-enhanced endoscopy using narrow band imaging or blue laser imaging play an integral role in the endoscopic diagnosis of oral and pharyngolaryngeal *** these advancements,limited studies have focused on benign lesions that can be observed during esophagogastroduodenoscopy in the oral and pharyngolaryngeal ***,this mini-review aimed to provide essential information on such benign lesions,along with representative endoscopic images of dental caries,cleft palate,palatal torus,bifid uvula,compression by cervical osteophytes,tonsil hyperplasia,black hairy tongue,oral candidiasis,oral and pharyngolaryngeal ulcers,pharyngeal melanosis,oral tattoos associated with dental alloys,retention cysts,papilloma,radiation-induced changes,skin flaps,vocal cord paresis,and vocal fold *** it is imperative to seek consultation from otolaryngologists or dentists in instances where the diagnosis cannot be definitively ascertained by endoscopists,the merits of attaining foundational expertise pertaining to oral and pharyngolaryngeal lesions are *** article will be a valuable resource for endoscopists seeking to enhance their understanding of oral and pharyngolaryngeal lesions.

关键词： Benign diseases Diagnosis Esophagogastroduodenoscopy Non-neoplastic lesions oral lesions Pharyngolaryngeal lesions

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oral and perioral herpes simplex virus infection type I in a fivemonth- old infant: A case report

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World Journal of Clinical Cases 2021年第3期9卷 685-689页

作者： Ashwag Yagoub Aloyouny Hamad Nasser Albagieh Rasha Hamed Al-Serwi Basic Dental Science Department College of DentistryPrincess Nourah bint Abdulrahman UniversityRiyadh 11671RiyadhSaudi Arabia oral Medicine and Diagnostic Science Department College of DentistryKing Saud UniversityRiyadh 12372RiyadhSaudi Arabia

BACKGROUND Herpes simplex virus(HSV)is a highly infectious pathogen that is easily transmitted via the bodily fluids of an infected *** virus usually affects individuals older than six months of age,and rarely causes lesions or symptoms in younger *** SUMMARY We present the case of a five-month-old healthy girl who presented with painful herpetic gingivostomatitis and perioral *** discuss the pathophysiology of primary HSV infection and the effect of maternal antibodies on the infant’s immune *** addition,we explain the diagnosis,management,and prognosis of HSV infection in young *** This case highlights the importance of early diagnosis and management of HSV infections to decrease the risk of developing severe complications and death.

关键词： Herpetic gingivostomatitis oral lesions Herpes simplex virus Perioral lesions Infants Case report Herpes simplex virus type 1

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