The clinical effectiveness of reflectance optical spectroscopy for the in vivo diagnosis of oral lesions

作     者：Diana V Messadi Fariba S Younai Hong-Hu Liu Gao Guo Cun-Yu Wang 

作者机构：Section of Oral Medicine and Orofacial Pain Division of Oral Biology and Medicine School of Dentistry University of California at Los Angeles Section of Oral Biology Division of Oral Biology and Medicine School of Dentistry University of California at Los Angeles Division of Public Health and Community Dentistry School of Dentistry University of California at Los Angeles David Geffen School of Medicine and Fielding School of Public Health 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2014年第6卷第3期

页      面：162-167页

核心收录：

学科分类：1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：National Institute of Dental and Craniofacial Research  NIDCR  (R37DE013848) 

主　　题：ansiosenesis optical spectroscopy oral lesions 

摘      要：Optical spectroscopy devices are being developed and tested for the screening and diagnosis of oral precancer and cancer lesions. This study reports a device that uses white light for detection of suspicious lesions and green–amber light at 545 nm that detect tissue vascularity on patients with several suspicious oral lesions. The clinical grading of vascularity was compared to the histological grading of the biopsied lesions using specific biomarkers. Such a device, in the hands of dentists and other health professionals, could greatly increase the number of oral cancerous lesions detected in early phase. The purpose of this study is to correlate the clinical grading of tissue vascularity in several oral suspicious lesions using the IdentafiH system with the histological grading of the biopsied lesions using specific vascular markers. Twenty-one patients with various oral lesions were enrolled in the study. The lesions were visualized using IdentafiH device with white light illumination, followed by visualization of tissue autofluorescence and tissue reflectance. Tissue biopsied was obtained from the all lesions and both histopathological and immunohistochemical studies using a vascular endothelial biomarker（CD34） were performed on these tissue samples. The clinical vascular grading using the green–amber light at 545 nm and the expression pattern and intensity of staining for CD34 in the different biopsies varied depending on lesions, grading ranged from 1 to3. The increase in vascularity was observed in abnormal tissues when compared to normal mucosa, but this increase was not limited to carcinoma only as hyperkeratosis and other oral diseases, such as lichen planus, also showed increase in vascularity. Optical spectroscopy is a promising technology for the detection of oral mucosal abnormalities; however, further investigations with a larger population group is required to evaluate the usefulness of these devices in differentiating benign lesions from potentially