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Aflibercept combined with triamcinolone acetonide in the treatment of diabetic macular edema:optical coherence tomography and optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 670-675页

作者： De-Shuang Li Hong-Xia Liao Chuan-He Zhang Jian-Guo Huang Wei Chen Jing-Lin Zhang Bo Qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Department of Ophthalmology the University of Hong Kong-Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To analyze the relationship between optical coherence tomography(OCT)and OCT angiography(OCTA)imaging in patients with diabetic macular edema(DME)who are treated with a combination of aflibercept and triamcinolone acetonide(TA).METHODS:A total of 76 eyes newly diagnosed DME were included in this study.They were randomly assigned to receive either aflibercept or a combination of aflibercept and TA.Injections once a month for a total of three injections.Central macular thickness(CMT),number of hyperreflective foci(HRF),height of subretinal fluid(SRF),and area of foveal avascular zone(FAZ)were evaluated using OCT and OCTA at baseline and after each monthly treatment.RESULTS:Both groups showed improvement in best corrected visual acuity(BCVA)and reduction in macular edema after treatment,and the difference in BCVA between the two groups was statistically significant after each treatment(P<0.05).The difference in CMT between the two groups was statistically significant after the first two injections(P<0.01),but not after the third injection(P=0.875).The number of HRF(1mo:7.41±8.25 vs 10.86±7.22,P=0.027;2mo:5.33±6.13 vs 9.12±8.61,P=0.034;3mo:3.58±3.00 vs 6.37±5.97,P=0.007)and height of SRF(1mo:82.39±39.12 vs 105.77±42.26μm,P=0.011;2mo:36.84±10.02 vs 83.59±37.78μm,P<0.01;3mo:11.57±3.29 vs 45.43±12.60μm,P<0.01)in combined group were statistically significant less than aflibercept group after each injection,while the area of FAZ showed no significant change before and after treatment in both groups.CONCLUSION:The combination therapy of aflibercept and TA shows more significant effects on DME eyes with decreased HRF and SRF.However,both aflibercept and combination therapy show no significant change in the area of FAZ.

关键词： diabetic macular edema optical coherence tomography optical coherence tomography angiography hyperreflective foci subretinal fluid foveal avascular zone aflibercept

Distal-scanning common path probe for optical coherence tomography

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Journal of Innovative optical Health Sciences 2024年第3期17卷 84-92页

作者： Zhengyu Chen Bin He Zichen Yin Zhangwei Hu Yejiong Shi Chengming Wang Xiao Zhang Ning Zhang Linkai Jing Guihuai Wang Ping Xue State Key Laboratory of Low-dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijingChina Frontier Science Center for Quantum Information BeijingChina Jinsp Company Limited BeijingChina Beijing Institute of Technology BeijingChina Institute of Forensic Science Ministry of Public Security BeijingChina Department of Neurosurgery Beijing Tsinghua Changgung HospitalSchool of Clinical Medicine and Institute of Precision MedicineTsinghua UniversityBeijingChina

In this paper,we present a distal-scanning common path probe for optical coherence tomography(OCT)equipped with a hollow ultrasonic motor and a simple and specially designed beam-splitter.This novel probe proves to be able to effectively circumvent polarization and dispersion mismatch caused by fiber motion and is more robust to a variety of interfering factors during the imaging process,experimentally compared to a conventional noncommon path probe.Furthermore,our design counteracts the attenuation of backscattering with depth and the fall-off of the signal,resulting in a more balanced signal range and greater imaging depth.Spectral-domain OCT imaging of phantom and biological tissue is also demonstrated with a sensitivity of∼100dB and a lateral resolution of∼3μm.This low-cost probe offers simplified system configuration and excellent robustness,and is therefore particularly suitable for clinical diagnosis as one-off medical apparatus.

关键词： Common path optical coherence tomography endoscopic probe

Deep learning-based inpainting of saturation artifacts in optical coherence tomography images

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Journal of Innovative optical Health Sciences 2024年第3期17卷 1-10页

作者： Muyun Hu Zhuoqun Yuan Di Yang Jingzhu Zhao Yanmei Liang Institute of Modern Optics Nankai UniversityTianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyTianjin 300350China Department of Thyroid and Neck Tumor Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Limited by the dynamic range of the detector,saturation artifacts usually occur in optical coherence tomography(OCT)imaging for high scattering media.The available methods are difficult to remove saturation artifacts and restore texture completely in OCT images.We proposed a deep learning-based inpainting method of saturation artifacts in this paper.The generation mechanism of saturation artifacts was analyzed,and experimental and simulated datasets were built based on the mechanism.Enhanced super-resolution generative adversarial networks were trained by the clear–saturated phantom image pairs.The perfect reconstructed results of experimental zebrafish and thyroid OCT images proved its feasibility,strong generalization,and robustness.

关键词： optical coherence tomography saturation artifacts deep learning image inpainting.

Reduced macular thickness and vascular density in abnormal glucose metabolism patients: A meta-analysis of optical coherence tomography (OCT) and OCT angiography studies

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中华医学杂志(英文版) 2024年第9期137卷 2024 Apr 2页

作者： Fu Xiangyu Ren Xiang Chen Wenyue Chen Danian Department of Ophthalmology West China Hospital Sichuan University Chengdu Sichuan China Research Laboratory of Ophthalmology and Vision Sciences State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu Sichuan China Department of Ophthalmology The People’s Hospital of Guizhou Province Guiyang Guizhou China

Background: Alterations in macular thickness and vascular density before clinically visible diabetic retinopathy (DR) remain inconclusive. This study aimed to determine whether retinal manifestations in abnormal glucose metabolism (AGM) patients differ from those in the healthy individuals.Methods: PubMed, Embase, and Web of Science were searched between 2000 and 2021. The eligibility criteria were AGM patients without DR. Primary and secondary outcomes measured by optical coherence tomography (OCT) and OCT angiography (OCTA) were analyzed and expressed as standardized mean differences (SMDs) with 95% confidence intervals (CIs). A random-effects model was used in the data synthesis. The potential publication bias for the variables was evaluated using Egger’s test.Results: A total of 86 observational studies involving 13,773 participants and 15,416 eyes were included. OCT revealed that compared to healthy controls, the total macular thickness of AGM patients was thinner, including the thickness of fovea (–0.24, 95% CI [–0.39, –0.08];P = 0.002,I2 = 87.7%), all regions of parafovea (–0.32, 95% CI [–0.54, –0.11];P = 0.003;I2 = 71.7%) and the four quadrants of perifovea; the thickness of peripapillary retinal nerve fiber layer (pRNFL), macular retinal nerve fiber layer (mRNFL), and ganglion cell layer (GCL) also decreased. OCTA indicated that the superficial and deep vascular density decreased, the foveal avascular zone (FAZ) area enlarged, and the acircularity index (AI) reduced in AGM individuals.Conclusions: Retinal thinning and microvascular lesions have occurred before the advent of clinically detectable DR; OCT and OCTA may have the potential to detect these preclinical changes.Registration: PROSPERO; http://www.***.york.***.uk/prospero/; No. CRD42021269885.

关键词： Abnormal glucose metabolism optical coherence tomography optical coherence tomography angiography Diabetic retinopathy Prediabetes Meta-analysis

optical coherence tomography evaluation of retinal nerve fiber layer thickness in non-arteritic anterior ischemic optic neuropathy and primary open angle glaucoma:a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1370-1380页

作者： Yu-Xin Tong Xin-Yu Zhang Yi He Zong-Lin Chen Bing Jiang Department of Ophthalmology Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Hunan Clinical Research Center of Ophthalmic Disease Changsha 410011Hunan ProvinceChina Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina Department of General Surgery Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

AIM:To assess the differences in average and sectoral peripapillary retinal nerve fiber layer(p RNFL)thickness using spectral domain optical coherence tomography(SD-OCT)in patients with non-arteritic anterior ischemic neuropathy(NAION)compared with those with primary open angle glaucoma(POAG).METHODS:A comprehensive literature search of the Pub Med,Cochrane Library,and Embase databases were performed prior to October,2021.Studies that compared the p RNFL thickness in NAION eyes with that in POAG eyes with matched mean deviation of the visual fields were included.The weighted mean difference(WMD)with 95%confidence interval(CI)was used to pool continuous outcomes.RESULTS:Ten cross-sectional studies(11 datasets)comprising a total of 625 eyes(278 NAION eyes,347 POAG eyes)were included in the qualitative and quantitative analyses.The pooled results demonstrated that the superior p RNFL was significantly thinner in NAION eyes than in POAG eyes(WMD=-6.40,95%CI:-12.22 to-0.58,P=0.031),whereas the inferior p RNFL was significant thinner in POAG eyes than in NAION eyes(WMD=11.10,95%CI:7.06 to 15.14,P≤0.001).No difference was noted concerning the average,nasal,and temporal p RNFL thickness(average:WMD=1.45,95%CI:-0.75 to 3.66,P=0.196;nasal:WMD=-2.12,95%CI:-4.43 to 0.19,P=0.072;temporal:WMD=-1.24,95%CI:-3.96 to 1.47,P=0.370).CONCLUSION:SD-OCT based evaluation of inferior and superior p RNFL thickness can be potentially utilized to differentiate NAION from POAG,and help to understand the different pathophysiological mechanisms between these two diseases.Further longitudinal studies and studies using eight-quadrant or clock-hour classification method are required to validate the obtained findings.

关键词： non-arteritic anterior ischemic optic neuropathy primar y open angle glaucoma optical coherence tomography peripapillary retinal nerve fiber layer thickness

optical coherence tomography of the pulmonary arteries in children with congenital heart diseases:A systematic review

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Pediatric Investigation 2022年第4期6卷 264-270页

作者： Ling Sun Qiuping Jiang Yumei Xie Shushui Wang Zhiwei Zhang Department of Pediatric Cardiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of South China Structural Heart DiseaseGuangzhouGuangdongChina

Importance:optical coherence tomography(OCT)is a high-resolution intravascular imaging tool and has shown promise for providing real-time quantitative and qualitative descriptions of pulmonary vascular structures in vivo in adult pulmonary hypertension(PH),while not popular in pediatric patients with congenital heart diseases(CHD).Objective:The aim of this review is to summarize all the available evidence on the use of OCT for imaging pulmonary vascular remodeling in pediatric patients.Methods:We conducted the systematic literature resources(Cochran Library database,Medline via PubMed,EMBASE,and Web of Knowledge)from January 2010 to December 2021 and the search terms were“PH”,“child”,“children”,“pediatric”,“OCT”,“CHD”,“pulmonary vessels”,“pulmonary artery wall”.Studies in which OCT was used to image the pulmonary vessels in pediatric patients with CHD were considered for inclusion.Results:Five studies met the inclusion criteria.These five papers discussed the study of OCT in the pulmonary vasculature of different types of CHD,including common simple CHD,complex cyanotic CHD,and Williams-Beuren syndrome.In biventricular anatomy,pulmonary vascular remodeling was primarily reflected by pulmonary intima thickening from two-dimensional OCT.In single-ventricle anatomy,due to the state of hypoxia,the morphology of pulmonary vessels was indirectly reflected by the number and shape of nourishing vessels from three-dimensional OCT.Interpretation:OCT may be an adequate imaging procedure for the demonstration of pulmonary vascular structures and provide additional information in pediatric patients.

关键词： Children Congenital heart diseases optical coherence tomography Pulmonary hypertension Pulmonary vessels

Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer's disease:a meta-analysis

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Neural Regeneration Research 2023年第11期18卷 2504-2513页

作者： Samran Sheriff Ting Shen Sandra Abdal Danit Saks Mehdi Mirzaei Veer Gupta Nitin Chitranshi Yuyi You Angela Schultz Stuart L.Graham Vivek Gupta Macquarie Medical School Macquarie UniversitySydneyNSWAustralia Save Sight Institute The University of SydneySydneyNSWAustralia School of Medicine Deakin UniversityMelbourneVICAustralia

Examining the retinal tissue has the potential to provide a unique method and technique to quantify Alzheimer’s disease-related changes in participants at various stages of the disease.In this metaanalysis,we aimed to investigate the association of various optical coherence tomography parameters with Alzheimer’s disease and whether retinal measurements can be used to diffe rentiate between Alzheimer’s disease and control subjects.Scientific databases including Google Schola r,Web of Science,and PubMed were systematically searched for published articles that evaluated retinal nerve fiber layer thickness and retinal microvascular network in Alzheimer’s disease and control subjects.Seventy-three studies(5850 participants,including 2249 Alzheimer’s disease patients and 3601controls) were included in this meta-analysis.Relative to controls,Alzheimer’s disease patients had a significantly lower global retinal nerve fiber layer thickness(standardized mean difference [SMD]=-0.79,95% confidence intervals [CI]:-1.03 to-0.54,P optical coherence tomography were significantly lower in Alzheimer’s disease than controls for macular thickness(pooled SMD:-0.44,95% CI:-0.67 to-0.20,P=0.0003),foveal thickness(pooled SMD=-0.39,95% CI:-0.58 to-0.19,P optical coherence tomography angiography parameters revealed mixed results between Alzheimer’s disease and controls.Superficial vessel density(pooled SMD=-0.42,95% CI:-0.68 to-0.17,P=0.0001) and deep vessel density(pooled SMD=-0.46,95% CI:-0.75 to-0.18,P=0.001) were found to be thinner in Alzheimer’s disease patients whereas the foveal avascular zone(SMD=0.84,95% CI:0.17-1.51,P=0.01) was larger in controls.Vascular density and thickness of various retinal laye rs were decreased in Alzheimer’s

关键词： Alzheimer’s disease foveal avascular zone macular thickness optical coherence tomography optical coherence tomography angiography retina retinal nerve fiber layer vessel density

Automated Classification of Inherited Retinal Diseases in optical coherence tomography Images Using Few-shot Learning

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Biomedical and Environmental Sciences 2023年第5期36卷 431-440页

作者： ZHAO Qi MAI Si Wei LI Qian HUANG Guan Chong GAO Ming Chen YANG Wen Li WANG Ge MA Ya LI Lei PENG Xiao Yan Department of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China Department of Computer Science RutgersThe State University of New JerseyNew Brunswick 08901USA Department of Computer Science and Engineering University at BuffaloBuffalo 14260USA Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Science KeyLaboratoryBeijing 100730China

Objective To develop a few-shot learning(FSL) approach for classifying optical coherence tomography(OCT) images in patients with inherited retinal disorders(IRDs).Methods In this study, an FSL model based on a student–teacher learning framework was designed to classify images. 2,317 images from 189 participants were included. Of these, 1,126 images revealed IRDs, 533 were normal samples, and 658 were control samples.Results The FSL model achieved a total accuracy of 0.974–0.983, total sensitivity of 0.934–0.957, total specificity of 0.984–0.990, and total F1 score of 0.935–0.957, which were superior to the total accuracy of the baseline model of 0.943–0.954, total sensitivity of 0.866–0.886, total specificity of 0.962–0.971,and total F1 score of 0.859–0.885. The performance of most subclassifications also exhibited advantages. Moreover, the FSL model had a higher area under curves(AUC) of the receiver operating characteristic(ROC) curves in most subclassifications.Conclusion This study demonstrates the effective use of the FSL model for the classification of OCT images from patients with IRDs, normal, and control participants with a smaller volume of data. The general principle and similar network architectures can also be applied to other retinal diseases with a low prevalence.

关键词： Few-shot learning Student-teacher learning Knowledge distillation Transfer learning optical coherence tomography Retinal degeneration Inherited retinal diseases

Bibliometric analysis of artificial intelligence and optical coherence tomography images:research hotspots and frontiers

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1431-1440页

作者： Hai-Wen Feng Jun-Jie Chen Zhi-Chang Zhang Shao-Chong Zhang Wei-Hua Yang Department of Software Engineering School of SoftwareShenyang University of TechnologyShenyang 110870Liaoning ProvinceChina Department of Computer School of Intelligent MedicineChina Medical UniversityShenyang 110122Liaoning ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen 518040Guangdong ProvinceChina

AIM:To explore the latest application of artificial intelligence(AI)in optical coherence tomography(OCT)images,and to analyze the current research status of AI in OCT,and discuss the future research trend.METHODS:On June 1,2023,a bibliometric analysis of the Web of Science Core Collection was performed in order to explore the utilization of AI in OCT imagery.Key parameters such as papers,countries/regions,citations,databases,organizations,keywords,journal names,and research hotspots were extracted and then visualized employing the VOSviewer and CiteSpace V bibliometric platforms.RESULTS:Fifty-five nations reported studies on AI biotechnology and its application in analyzing OCT images.The United States was the country with the largest number of published papers.Furthermore,197 institutions worldwide provided published articles,where University of London had more publications than the rest.The reference clusters from the study could be divided into four categories:thickness and eyes,diabetic retinopathy(DR),images and segmentation,and OCT classification.CONCLUSION:The latest hot topics and future directions in this field are identified,and the dynamic evolution of AIbased OCT imaging are outlined.AI-based OCT imaging holds great potential for revolutionizing clinical care.

关键词： artificial intelligence optical coherence tomography bibliometric deep learning machine learning