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Effects of minocycline on apoptosis and neuronal changes in retinal ganglion cells from experimental optic neuritis rats

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Neural Regeneration Research 2008年第12期3卷 1348-1351页

作者： Jing Zhang Department of Ophthalmology First Affiliated Hospital Chongqing Medical University Chongqing 400016 China

BACKGROUND： Minocycline, a tetracycline derivative, is neuroprotective in models of various neurological diseases. OBJECTIVE： To investigate the effects of minocycline on retinal ganglion cells （RGCs） in rats with optic neuritis, and to compare with the effects of methylprednisolone. DESIGN, TIME AND SETTING： This neuropathology controlled study was performed at the First Affiliated Hospital, Chongqing Medical University, China in May 2007. MATERIALS： A total of 22 female Wistar rats were randomly assigned into a normal control group （n ： 5） and an experimental group （n = 17）. The experimental group was composed of a model subgroup （n = 7）, a minocycline subgroup （n = 5）, and a methylprednisolone subgroup （n = 5）. Minocycline was supplied by Sigma, USA. METHODS： Antigen homogenate made from guinea pig spinal cord and complete Freund adjuvant was used to induce autoimmune encephalomyelitis, which could induce demyelinated optic neuritis models. Rats in the minocycline subgroup were intraperitoneally injected with minocycline （45 mg/kg） daily from day 8 following autoimmunity. Rats in the methylprednisolone subgroup were intraperitoneally injected with methylprednisolone （20 mg/kg） daily from day 8 following autoimmunity. MAIN OUTCOME MEASURES： On day 18 after autoimmunily induction, pathological changes in the optic nerve were observed by hematoxylin-eosin staining. The percentage area of axons in the transverse section of the optic nerve was measured by Bielschowsky staining. Apoptosis of RGCs was detected by TUNEL. RESULTS： Under an optical microscope, the optic nerve in rats with demyelinated optic neuritis showed a vacuole-like structure of fibers, irregular swelling of the axons, and infiltration of a large quantity of inflammatory cells. With an electron microscope, the optic nerve presented with vacuole-like structures in the axons, a small percentage area of axons in the transverse section, loose myelin sheaths, and microtubules and microfilaments disappeared

关键词： optic neuritis retinal ganglion cells minocycline methylprednisolone

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Comparison of macular changes according to the etiology of optic neuritis:a cross-sectional study

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 686-692页

作者： Yeji Moon Sung-Min Kim Jae Ho Jung Department of Ophthalmology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Neurology Seoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University HospitalSeoul 03080Republic of Korea Department of Ophthalmology Seoul National University College of MedicineSeoul 03080Republic of Korea

AIM:To compare the macular structure including foveal thickness among patients with optic neuritis(ON)according to the etiology and to investigate the possible correlation between structural and visual outcomes METHODS:In this retrospective cross-sectional study,the clinical data of patients with aquaporin-4 immunoglobulin G-related ON(AQP4 group,40 eyes),myelin oligodendrocyte glycoprotein IgG-related ON(MOG group,31 eyes),and multiple sclerosis-related ON(MS group,24 eyes)were *** retinal thickness of the foveal,parafoveal and perifoveal regions were *** acuity(VA),visual field index and mean deviation were measured as visual ***:The AQP4 group showed a significantly thinner fovea(226.4±13.4μm)relative to the MOG(236.8±14.0μm,P=0.015)and MS(238.9±14.3μm,P=0.007)*** thickness in the parafoveal area also was thinner in the AQP4 group,though the difference in perifoveal retinal thickness was not *** thickness was correlated with VA in the AQP4 group(coefficientρ=-0.418,P=0.014),but not in the MOG and MS groups(P=0.218 and P=0.138,respectively).There was no significant correlation between foveal thickness and visual field test in all three ***:The significant thinning in the fovea and parafoveal areas in the AQP4 group compared to the MOG and MS groups are ***,macular changes in AQP4-ON show a significant correlation with *** results provide the possibility that retinal structural damage could reflect functional damage in AQP4-ON,distinct from MOGON and MS-ON.

关键词： foveal thickness optic neuritis aquaporin-4 immunoglobulin myelin oligodendrocyte glycoprotein multiple sclerosis

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optical coherence tomography in central nervous system demyelinating diseases related optic neuritis

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International Journal of Ophthalmology(English edition) 2018年第10期11卷 1649-1656页

作者： Nattapong Mekhasingharak Poramaet Laowanapiban Sasitorn Siritho Chanjira Satukijchai Naraporn Prayoonwiwat Jiraporn Jitprapaikulsan Niphon Chirapapaisan Department of Ophthalmology Naresuan University HospitalNaresuan University Phitsanulok 65000 Thailand Department of Ophthalmology Mettapracharak HospitalNakhon Pathom 73110 Thailand Division of Neurology Department of Medicine SirirajHospital Mahidol University Bangkok 10700 Thailand Bumrtmgrad International Hospital Bangkok 10110 Thailand Bangkok Hospital Headquarters Bangkok 10310 Thailand Department of Ophthalmology Siriraj Hospital MahidolUniversity Bangkok 10700 Thailand

AIM：To compare the thickness of the peripapillary retinal nerve fiber layer（RNFL）and ganglion cell-inner plexiform layer（GCIPL）among patients with various forms of optic neuritis（ON）and to identify whether any particular parameters or their thinning pattern can be used to distinguish the type of ***：This prospective study was conducted at the Department of Ophthalmology,Faculty of Medicine,Siriraj Hospital,Thailand,between January,2015 and December,*** enlisted patients over 18 years of age with history of ON and categorized patients into 4 groups：1）aquaporin 4 antibodies（AQP4-IgG）positive;2）multiple sclerosis（MS）;3）myelin oligodendrocyte glycoprotein antibodies（MOG-IgG）positive;4）idiopathic-ON *** controls were also included during the same study *** patients underwent complete ophthalmological examination and spectral domain optical coherence tomography（OCT）imaging to analyze RNFL and GCIPL thickness after at least 3mo since the last episode of acute *** generalized estimating equation（GEE）models were used to compare the data amongst ON groups. RESULTS： Among 87 previous ON eyes from 57 patients（43 AQP4-IgG＋ON,17 MS-ON,8 MOG-IgG＋ON,and 19idiopathic-ON）,mean logMAR visual acuity of AQP4-IgG＋ON,MS-ON,MOG-IgG＋ON,and idiopathic-ON groups was 0.76±0.88,0.12±0.25,0.39±0.31,and 0.75±1.08,***,superior,and inferior RNFL were significantly reduced in AQP4-IgG＋ON,MOG-IgG＋ON and idiopathic-ON eyes,relative to those of *** were not statistically significant for RNFL or GCIPL between the AQP4-IgG＋ON and MOG-IgG＋ON groups,whereas visual acuity in MOG-IgG＋ON was slightly,but not significantly,better（0.39 vs 0.76）.Although RNFL thickness in MOG-IgG＋ON was significantly reduced as compared to MS-ON,mean visual acuity and GCIPL were not ***：Thinning of superior and inferior quadrants of RNFL are more commonly seen in MOG-IgG＋ON and AQP4-IgG＋*** term visual acuity in MOG-IgG＋ON is often better than

关键词： optical coherence tomography neuromyelitis optica multiple sclerosis myelin oligodendrocyte glycoprotein antibody optic neuritis

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Structural-visual functional relationships detected by optical coherence tomography in varying age-cohorts' patients with optic neuritis

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 967-974页

作者： Wei Shi Hong-Tao Zhang Hua-Xin Zuo Si-Yuan Li Pan-Pan Zheng Quan-Gang Xu Si-Yu Cai Shi-Hui Wei Li Li Chun—Xia Peng Department of Ophthalmology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Ophthalmology the Third Medical Center of Chinese PLA General HospitalBeijing 100039China Clinical Epidemiology and Evidence-based Medicine Beijing Children's HospitalCapital Medical UniversityNational Center for Children’s HealthBeijing 100045China Department of Ophthalmology the First Medical Center of Chinese PLA General HospitalBeijing 100853China

AIM: To assess the relationships of final best-corrected visual acuity(BCVA) and the optic nerve structural loss in varying age-cohorts of optic neuritis(ON) ***: This is a retrospective, cross-sectional *** 130 ON subjects(200 eyes) without ON onset within 6mo were included, who underwent BCVA assessment,peripapillary retinal nerve fibre layer(pRNFL) and macular segmented layers evaluation by optical coherence tomography(OCT).RESULTS: For the 0-18y cohort, the final BCVA(logMAR)was significantly better and less frequent recurrences than adult cohorts(P=0.000). The final BCVA(logMAR) in all age-cohorts of the ON patients had negative and linear correlations to the pRNFL thicknesses and macular retinal ganglion cell layer(mRGCL) volumes, when the pRNFL thicknesses were reduced to the thresholds of 57.2-67.5 μm or 0.691-0.737 mm;in mRGCL volumes, respectively, with the strongest interdependence in the 19-40y cohort. The ON patients from varying age cohorts would be threatened by blindness when their pRNFL thicknesses dropped 36.7-48.3 μm or the mRGCL volumes dropped to 0.495-0.613 mm;.CONCLUSION: The paediatric ON has best prognosis and young adult ON exhibits perfectly linear correlations of final vision and structural loss. The pRNFL and the mRGCL could be potential structural markers to predict the vision prognosis for varying-age ON patients.

关键词： optic neuritis age-cohort final visual acuity structural impairment linear correlations

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Choroidal changes in eyes treated with high-dose systemic corticosteroids for optic neuritis

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1430-1435页

作者： Jun Hyuk Lee Ji Young Lee Ho Ra Nam Yeo Kang Jiwon Baek Department of Ophthalmology Bucheon St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaGyeonggi-do 14647Republic of Korea Department of Ophthalmology Yeoeuido St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591Republic of Korea

AIM:To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic ***:A retrospective comparative cohort ***-six eyes of 38 patients with unilateral optic neuritis that received systemic high-dose corticosteroid treatment were *** thickness(CT)and choroidal vascularity index(CVI)were measured in both affected and the fellow eyes at baseline,1 wk.1 and 3 *** in CT and CVI were analyzed in both eyes and compared between ***:The mean CT and CVI were 349μm and 0.70 in the affected eyes and 340μm and 0.69 in the fellow eyes at baseline(P=0.503 and 0.440,respectively).Decrement of CT and CVI at month 3 were significant in affected eyes(P=0.017 and Poptic neuritis patients treated with high-dose systemic corticosteroid *** decrease in CVI appeared earlier than the decrease in CT,suggesting choroidal vasoconstriction caused by systemic steroid as a possible mechanism.

关键词： corticosteroid optic neuritis choroidal thickness prednisolone

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Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 120-123页

作者： Peter W.MacIntosh S.Vijay Kumar V.R.Saravanan Virna M.Shah Illinois Eye and Ear Infirmary University of Illinois at ChicagoChicagoIL 60612USA Neuro-Ophthalmology Service Aravind Eye HospitalCoimbatore 641014India

AIM:To elucidate the changes of different ganglion cell layer(GCL)thinning patterns between the optic neuritis(ON)and non-arteritic anterior ischemic optic neuropathy(NAION).METHODS:A prospective,observational study was conducted to evaluate the timing of GCL changes between acute ON and NAION using optical coherence ***:Thinning on optical coherence tomography in the NAION group occurs as early as 11 d after symptomatic onset of vision loss and follows an altitudinal *** mean superior-inferior GCL thickness difference in the NAION cohort was clinically significant at 5.7μm in the NAION cohort compared to controls of 0.8μm(P=0.032),but not significant in the ON group compared to controls with both groups measuring 1.1μ*** thinning was significant for the ON group compared to controls at 7.2μm(P=0.011)but not the NAION group compared to controls at 1.35μ***:These findings suggest that future treatments for NAION should be given early,and possibly before 11 d in order to prevent GCL and irreversible vision loss.

关键词： optic neuritis non-arteritic ischemic optic neuropathy optical coherence tomography ganglion cell layer

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Bilateral retinal nerve fiber layer thickness reduction in a 9-year-old myopic boy suffering from unilateral optic neuritis:A case report

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World Journal of Clinical Cases 2023年第28期11卷 6806-6811页

作者： Fang-Fang Zhao Shi-Qi Yao Yun Wang Tai-Ping Li Jian-Feng Yang Chi-Pui Pang Ling-Ping Cen Department of Medical Retina and Neuro-ophthalmology Joint Shantou International Eye Centre of Shantou University and The Chinese University of Hong KongShantou 515041Guangdong ProvinceChina Department of Ophthalmology&Visual Sciences The Chinese University of Hong KongHong Kong 999077China

BACKGROUND In this paper,we present a 9-year-old boy who demonstrates a complex interplay between myopia progression,axial length(AL)extension,and retinal nerve fiber layer(RNFL)thickness loss in both ***,concurrent optic neuritis has directly impacted RNFL thickness in his right eye,and its potential indirect influence on RNFL and macular ganglion cell layer(mGCL)thickness in his left eye is also *** SUMMARY A 9-year-old boy with bilateral myopia presented with diminished vision and pain in his right eye due to optic neuritis,while his left eye showed *** therapy improved his vision in the right eye,and 16-mo follow-up revealed recovery without recurrence despite myopia ***-up optical coherence tomography conducted 16 mo later revealed a notable thinning of the RNFL in both eyes,especially along with a reduction in mGCL thickness in the left *** intricate interaction between optic neuritis,myopia,and retinal changes underscores the need for comprehensive management,highlighting potential long-term visual implications in young *** The progression of myopia and AL extension led to the loss of RNFL thickness in both eyes in a 9-year-old ***,optic neuritis directly affected RNFL thickness in his right eye and may indirectly play a role in the thickness of RNFL and mGCL in his left eye.

关键词： Retinal nerve fiber layer Myopia optic neuritis Macular ganglion cell Case report

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optic neuritis combined with hepatitis B and neurosyphilis

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Chinese Medical Journal 2013年第18期126卷 3580-3581页

作者： JIANG Zhao-cai LIU Zi-hao LI Hong-yang WEI Shi-hui Department of Ophthalmology General Hospital of People's Liberation Amay Beijing 100853 China

optic neuritis is defined as inflammation of the optic nerve. Pain and vision loss are common symptoms ofoptic neuritis. The most frequent cause of optic neuritis is multiple sclerosis： other reasons include viral and bacterial infections, such as hepatitis B and syphilis. We describe a case of a 60-year-old man with a 3-year history of decreased vision acuity in his right eye and a 1-year history of decreased vision acuity in his left eye with light headedness who was admitted to the Neuro- ophthalmological Department of the General Hospital of Chinese People＇s Liberation Army. He had a 2-year past medical history of hypertension and blood pressure instability. None of his family members suffered from vision loss and he had no systemic diseases, especially diabetes mellitus as well as drug usage or toxic exposure.

关键词： optic neuritis hepatitis B neurosyphilis

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An unusual cause of optic neuritis:rickettsiosis disease

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Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 998-1000页

作者： Loukil Hanen Snoussi Mouna Frikha Faten Ben Salah Raida Jallouli Moez Cherif Yosra EI Aoud Sahar Marzouk Sameh Bahloul Zouhir Department of Internal Medicine Hedi Chaker University Hospital

optic neuritis(ON) may be associated to a range of autoimmune or infectious *** report herein a case of ON induced by Rickettsia conorii.A 53-year-old woman presented with a recent decrease in visual acuity and *** was diagnosed on the basis of ophthalmologic examination and flash visual evoked *** investigation made in our department eliminated first autoimmune disorders(vasculitis and connective tissue diseases).Rickettsial optic neuritis was confirmed by detection of specific antibodies in serum and the negativity of other serologic *** association between corticosteroids and cyclines was prescribed with improvement of visual acuity.

关键词： optic neuritis Rickettsia conorii Mediterranean spotted fever Ocular involvement

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optic neuritis in Acute Neuroborreliosis (Lyme Disease) in the U.S.-Mexican Border: Case Report

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World Journal of Neuroscience 2016年第2期6卷 126-130页

作者： Ihtesham A. Qureshi Michael F. Maldonado Gustavo J. Rodriguez Salvador Cruz-Flores Alberto Maud Neurology Department Texas Tech University Health Sciences Center El Paso USA Ophthalmology Department Texas Tech University Health Sciences Center El Paso USA

Objective: We describe a patient diagnosed with acute neuroborreliosis presenting with anterior optic neuritis (papillitis) in a non-endemic region. Case Presentation: A 43-year-old previously healthy right handed man admitted due to an insidious onset of severe headache and spells of ascending paresthesias from his right foot into his right arm and face followed by speech arrest and clumsiness of his right hand. His neurologic exam was significant for somnolence, nuchal rigidity and Kernig and Brudzinski signs were present. MRI of the brain with gadolinium showed diffuse hyperintense signal involving the supra and infratentorial cortical sulci, with associated faint diffuse leptomeningeal enhancement, consistent most likely with diffuse leptomeningoencephalitis. EEG: normal. CSF VDRL was negative. Dilated fundus exam revealed mild optic nerve edema more significant to the left than to the right eye, confirmed and measured by spectral domain OCT (optical Coherence Tomography). There was an evidence of posterior uveitis with an early vitreous hemorrhage superficial to the left optic nerve. Lyme disease serum antibody (IgM) Immunoblotting was positive in 2 bands confirming the diagnosis of neuroborreliosis. Conclusion: optic nerve involvement in Lyme disease is an uncommon complication that should be confirmed by specific diagnostic criteria to establish its causal relation.

关键词： optic neuritis Lyme Disease Non-Endemic Papillitis

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