Choroidal changes in eyes treated with high-dose systemic corticosteroids for optic neuritis

作     者：Jun Hyuk Lee Ji Young Lee Ho Ra Nam Yeo Kang Jiwon Baek 

作者机构：Department of OphthalmologyBucheon St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaGyeonggi-do 14647Republic of Korea Department of OphthalmologyYeoeuido St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591Republic of Korea 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2020年第13卷第9期

页      面：1430-1435页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

主　　题：corticosteroid optic neuritis choroidal thickness prednisolone 

摘      要：AIM:To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic ***:A retrospective comparative cohort ***-six eyes of 38 patients with unilateral optic neuritis that received systemic high-dose corticosteroid treatment were *** thickness(CT)and choroidal vascularity index(CVI)were measured in both affected and the fellow eyes at baseline,1 wk.1 and 3 *** in CT and CVI were analyzed in both eyes and compared between ***:The mean CT and CVI were 349μm and 0.70 in the affected eyes and 340μm and 0.69 in the fellow eyes at baseline(P=0.503 and 0.440,respectively).Decrement of CT and CVI at month 3 were significant in affected eyes(P=0.017 and P0.001).Decreased CVI began 2 wk after treatment whereas CT decreased from 1 *** CVI also decreased significantly in fellow eyes at 3 mo compared to the baseline(P=0.001).CONCLUSION:A significant decrement in CT and CVI can appear after 3 mo in optic neuritis patients treated with high-dose systemic corticosteroid *** decrease in CVI appeared earlier than the decrease in CT,suggesting choroidal vasoconstriction caused by systemic steroid as a possible mechanism.