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Safety and efficacy of bimatoprost/timolol fixed combination in Chinese patients with open-angle glaucoma or ocular hypertension

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Chinese Medical Journal 2014年第5期127卷 905-910页

作者： Ling Zhihong Zhang Mingchang Hu Yizhen Yin Zhengqin Xing Yiqiao Fang Aiwu Ye Jian Chen Xiaoming Liu Dachuan Wang Yusheng Sun Wei Dong Yangceng Sun Xinghuai Department of Ophthalmology Eye and ENT Hospital Fudan University Shanghai 200031 China

Background Lowering intraocular pressure （lOP） is currently the only therapeutic approach in primary open-angle *** the fixed-combination medications are needed to achieve sufficiently low target lOP.A multicenter prospective study in the Chinese population was needed to confirm the safety and efficacy of Bimatoprost/Timolol Fixed Combination Eye Drop in *** this study,we evaluated the safety and efficacy of Bimatoprost/Timolol Fixed Combination with concurrent administration of its components in Chinese patients with open-angle glaucoma or ocular *** In this multicenter,randomized,double-masked,parallel controlled study,patients with open-angle glaucoma or ocular hypertension who were insufficiently responsive to monotherapy with either topical β-blockers or prostaglandin analogues were randomized to one of two active treatment groups in a 1：1 ratio at 11 Chinese ophthalmic ***/timolol fixed combination treatment was a fixed combination of 0.03％ bimatoprost and 0.5％ timolol （followed by vehicle for masking） once daily at 19：00 *** concurrent treatment was 0.03％ bimatoprost followed by 0.5％ timolol once daily at 19：00 *** primary efficacy variable was change from baseline in mean diurnal intraocular pressure （IOP） at week 4 visit in the intent-to-treat （ITr） *** analysis evaluated the non-inferiority of bimatoprost/timolol fixed combination to concurrent with respect to the primary variable using a confidence interval （CI） ***/timolol fixed combination was to be considered non-inferior to concurrent if the upper limit of the 95％ CI for the between-treatment （bimatoprost/timolol fixed combination minus concurrent） difference was-≤1.5 *** events were collected and slit-lamp examinations were performed to assess ***-group comparisons of the incidence of adverse events were performed using the Pearson chi-square test or Fisher＇s exact *** Of the enroll

关键词： glaucoma open-angle bimatoprost/timolol fixed combination bimatoprost

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Incidence of Primary open-angle Glaucoma at the Flamboyants Communal Medical Center of Conakry, Guinea

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open Journal of Ophthalmology 2022年第3期12卷 233-241页

作者： Pierre Louis Lama Aly Sylla Sidikiba Camara Céougna Sagno Oumar Raphiou Diallo Ibrahima Sory Souaré National Noncommunicable Diseases Programme Conakry Guinea FSTS Gamal Abdel Nasser University of Conakry Conakry Guinea Department of Ophthalmology Regional Hospital of N’Zerekore Zerekore Guinea Department of Neurosurgery Sino Guinean Friendship Hospital Conakry Guinea

Background: Primary open-angle Glaucoma (POAG) is a chronic, progressive optic neuropathy of multifactorial origin defined by alterations in the visual field, progressive loss of optic nerve fibers and ganglion cells, and an open iridocorneal angle in gonioscopy. It is the world’s leading cause of irreversible blindness. There is no epidemiological study in Guinea that allows us to locate the real level of the problem. The objective of this study is to determine the hospital incidence of POAG at the Centre Médical Communal (CMC) in the Flamboyants. Patients and Method: This was a descriptive cross-sectional study with a prospective collection for one year, from April 1, 2020 to March 31, 2021, in patients aged at least 40 years, received in consultation at the CMC in the Flamboyants. The diagnostic criterion for a new case of glaucoma was the presence in a patient of the following two signs: (excavation of the optical disc C/D ≥ 0.5 and alteration of the visual field) with an open angle at least stage 4 of the Shaffer and Etienne classification associated or not with ocular hypertonia and having never received anti glaucoma treatment. We described variables related to sociodemographic characteristics, visual acuity, intraocular pressures, papillary excavations, and visual field surveys. Informed consent from patients was sought and obtained. The confidentiality of the files was guaranteed. Results: 68 new cases of POAG were diagnosed out of 3220 consultations, an incidence rate of 2.11%. The average age was 58.2 years (10.64 with a male predominance of 63.23%. A family history of glaucoma was present in 11.36% of cases. Visual acuity was poor Conclusion: This study has shown us that POAG in our environment is relatively common, early onset, and rapidly evolving. The implementation of a rapid and reliable screening strategy by the Eye Health Program will make it possible to manage glaucoma from the earliest stages.

关键词： Primary Glaucoma open-angle Incidence Conakry Guinea

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Expression of Mesenger RNA for Transforming Growth Factor-β_1 in Bovine Trabecular Meshwork

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Eye Science 1996年第1期16卷 1-4页

作者： Liya Yuan, Houren WeiDepartment of Ophthalmology, Union Hospital, Tongji Medical University, Wuhan 430022,China Department of Ophthalmology Union Hospital Tongji Medical University Wuhan China.

Purpose: To investigate the relationship between transforming growth factor-β1(TGF-β1) and primary open-angle glaucoma, we have determined whether trabec-ular tissues have the expression of messenger RNA for TGF-β***: Total RNA of 24 newborn bovine trabecular tissue were extracted byGuanidine isothiocyanate method. The TGF-β33 plasmid was brought into E. col-ibacillius HB101 and amplificated. After Bam HI endolase degradation and labelwith a-32p-dATP the RNA was hybridized with the cDNA (complementary DNA)probe and examined by ***: The presence of mRNA for TGF-β1 in bovine trabecular meshwork ***: The TGF-β1 present in normal aqueous humor must be at least partlyderived from the trabecular meshwork. It offered a basis for understanding therelationship between abnormal synthesis, activation and clearance of TGF-β1 andthe pathogenesis of primary open-angle glaucoma (POAG) in molecular *** Science 1996; 12:1-4.

关键词： trabecular meshwork transforming growth factor-β1 open-angle glaucoma

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Ethylenediaminetetraacetic Acid Chelation for Band Keratopathy before Ab Interno Glaucoma Surgery

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open Journal of Ophthalmology 2019年第4期9卷 165-167页

作者： Tomoki Shirakami Yasuyuki Takai Mihoko Mochiji Masaki Tanito Department of Ophthalmology Faculty of Medicine Shimane University Shimane Japan

An 87-year-old woman with primary open-angle glaucoma presented to our hospital. Although the combined cataract and minimally invasive glaucoma surgeries (MIGS) were an appropriate surgical option, the presence of band keratopathy made it difficult to perform ab interno glaucoma surgery in her right eye (OD);therefore, the corneal opacity was removed using ethylenediaminetetraacetic acid (EDTA) chelation procedure. One month after chelation, microhook ab interno trabeculotomy and cataract surgery were performed successfully. Clear intraoperative visualization of the angle structures is critical for the success of these MIGS procedures. In glaucomatous eyes that require MIGS, EDTA chelation is a good neoadjuvant therapy for coexisting band keratopathy.

关键词： Microhook Ab Interno Trabeculotomy Minimally Invasive Glaucoma Surgery (MIGS) Band Keratopathy Primary open-angle Glaucoma Ethylene-Diamine-Tetra-Acetic Acid (EDTA) Chelation

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