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Plasma Science and Technology 2020年第2期22卷 87-94页

作者： Qunxia ZHANG Cao FANG Zhu CHEN Qing HUANG Key Laboratory of High Magnetic Field and Ion Beam Physical Biology Institute of Technical Biology and Agriculture EngineeringHefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China Anhui Jianzhu University Hefei 230601People's Republic of China

Fungal infection of human nails,or onychomycosis,affects 10%of the world's adult population,but current therapies have various *** this work,we employed a self-made low-temperature plasma(LTP)device,namely,an atmospheric-pressure plasma jet(APPJ)device to treat the nails infected with Trichophyton rubrum(***)with the aid of persulfate *** found that persulfate solution had a promoting effect on plasma treatment of *** addition of sodium persulfate,the APPJ therapy could cure onychomycosis after several times of *** such,this work has demonstrated a novel and effective approach which makes good use of LTP technique in the treatment of onychomycosis.

关键词： low-temperature plasma(LTP) persulfate onychomycosis Trichophyton rubrum(T rubrum)

Analysis of the Factors Influencing the Therapeutic Effects of onychomycosis

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2001年第3期21卷 259-262页

作者：郑岳臣邬焱卿陈辉祝兆如刘凌曾静思 Department of Dermat-Venerology Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan

In order to improve the curative effect of onychomycosis, the factors influencing the therapeutic effects were investigated. 545 cases including 245 males and 300 females, who were diagnosed both clinically and mycologically, were treated by Intraconazole with intermittent pulse therapy. The therapeutic effects were judged by the following observations regularly and analyzed from the factors as follows: age; growing speed of nails; accompanied diseases; family history; trauma of nails; infection ways of the pathogens; manifestation of the injury; pathogens; duration of the treatment. The results showed that the recovery rate was higher in younger patients (Ponychomycosis caused by T. rubrum had a higher recovery rate (Ponychomycosis caused by Candida or

关键词： onychomycosis curative effect influencing factor

Self-controlled Study of onychomycosis Treated with Long-pulsed Nd：YAG 1064-nm Laser Combined with Itraconazole

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Chinese Medical Journal 2016年第16期129卷 1929-1934页

作者： Yan Li Jing Xu Jun-Ying Zhao Feng-Lin Zhuo Department of Dermatology Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Dermatology Capital Institute of Pediatrics Beijing 100020 China

Background： onychomycosis is a fungal infection of the nail plate and subungual area. In this study, we examined the efficacy of laser treatment using self-controlled study programs involving a long-pulsed Nd：YAG 1064-nm laser combined with oral medication. Methods： Self-controlled strategies were followed in this study. The patients received treatment with oral itraconazole in conjunction with long-pulsed Nd：YAG 1064-nm laser treatment at the nails of the unilateral limb once a week for a total of four times. A total of 84 affected nails were divided into Group A （mild to moderate） and Group B （severe） according to disease severity. Affected nails with the same Scoring Clinical Index for onychomycosis scores were selected to compare the therapeutic effects of the pure medication treatment group and the combination treatment group with a 24-week follow-up period. Results： In Group A, at the 8th, 16th, and 24th weeks of follow-up, the efficacies in the pure medication treatment group were 81.0%, 81.0%, and 90.5%, respectively, while those in the combination treatment group were 100%, 95.2%, and 90.5%, respectively. The differences between groups were not significant （8th week： χ2 =4.421, P 〉 0.05; 16th week： χ2 = 2.043, P 〉 0.05; 24th week： χ2= 0.00, P 〉 0.05）. In Group B, at the 8th, 16th, and 24th weeks of follow-up, the efficacies in the pure medication treatment group were 61.9%, 66.7%, and 52.4%, respectively, while those in the combination treatment group were 95.2%, 90.5%, and 100%, respectively. The differences between groups at the 8th and 24th weeks of follow-up were statistically significant （8th week： χ2=6.929, P 〈 0.05; 24th week： χ2=13.125, P 〈 0.05）. Conclusions： For patients with mild or moderate onychomycosis, we recommended a pure medication treatment or combination treatment with medication and laser. For those patients with severe onychomycosis, we recommended a combination of medication and laser therapy.

关键词： ltraconazole Laser Treatment Nd-YAG Laser onychomycosis

Long-pulse Nd：YAG 1064-nm laser treatment for onychomycosis

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Chinese Medical Journal 2012年第18期125卷 3288-3291页

作者： ZHANG Rui-na WANG Dong-kun ZHUO Feng-lin DUAN Xiao-han ZHANG Xiao-yan ZHAO Jun-ying Department of Dermatology Beijing Friendship Hospital CapitalMedical University China Beijing 100050 Department of Dermatology China-Japan Friendship Hospital China Beijing 100029

Background Recent research shows that lasers can inhibit fungal growth and that Nd：YAG 1064-nm lasers can penetrate as deep as the lower nail plate. The aim of this study was to observe the effect of a long-pulse Nd：YAG 1064-nm laser on 154 nails of 33 patients with clinically and mycologically proven onychomycosis. Methods Thirty-three patients with 154 nails affected by onychomycosis were randomly assigned to two groups, with the 154 nails divided into three sub-groups （Ⅱ degree,Ⅲ degree, and IV degree） according to the Scoring Clinical Index of onychomycosis. The 15 patients （78 nails） in group 1 were given eight sessions with a one-week interval, and the 18 patients （76 nails） in group 2 were given four sessions with a one-week interval. Results In group 1, the effective rates at 8 weeks, 16 weeks, and 24 weeks were 63%, 62%, and 51%, respectively, and the effective rates in group 2 were 68%, 67%, and 53% respectively. The treatment effect was not significantly different between any sub-group pair （P 〉0.05）. Conclusions Long pulse Nd：YAG 1064-nm laser was effective for onychomycosis. It is a simple and effective method without significant complications or side effects and is expected to become an alternative or replacement therapy for onychomycosis.

关键词： onychomycosis laser, treatment

Rapid Visible Improvements in onychomycosis: An Open-Label Clinical Investigation of Kerasal Nail<sup>TM</sup>

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第1期7卷 57-66页

作者： Jiun Yit Pan Chris Lixian Tan Anders Toft National Skin Centre Singapore City Singapore Division of Dermatology National University Hospital Singapore City Singapore Moberg Pharma AB Bromma Sweden

Traditional treatments for onychomycosis, a fungal disease primarily affecting the toenails, are associated with poor tolerability or inadequate efficacy. Moreover, because many patients find onychomycosis embarrassing, achieving rapid cosmetic improvements is desirable. Kerasal NailTM is a marketed topical treatment containing propylene glycol, urea and lactic acid. The ability of Kerasal Nail to improve the appearance of an affected nail was investigated in a 4-week open-label study. Patients aged ≥21 years and with 25% to 75% of a big toenail or thumbnail (the “target” nail) affected by clinically suspected onychomycosis (n = 65) were instructed to apply Kerasal Nail to all their affected nails once daily for 4 weeks. After 1, 2 and 4 weeks of treatment, they assessed the appearance of the target nail on a 4-point scale, with a score of ≥2 indicating a minimum of some improvement. They also assessed the nail for improvements in thickening, discoloration, brittleness and softness. Adverse events (AEs) occurring between administration of the first dose of Kerasal Nail and the end of the 4-week treatment period were recorded. 85% of patients (95% confidence interval [CI] 74 to 92) achieved some improvement in the target nail at 4 weeks. Improvement of the target nail was reported by 65% of patients (95% CI 52 to 76) after 1 week of treatment and by 82% of patients (95% CI 70 to 90) after 2 weeks. 55% of patients achieved some improvement in discoloration in the first week of treatment. After 4 weeks of treatment, discoloration, thickening, brittleness and softness were each improved in more than half of patients. Treatment-related AEs were limited to two cases of administration site pain. Overall treatment compliance was 99%. In summary, Kerasal Nail produced very rapid improvements in nail appearance in patients with onychomycosis and was well tolerated.

关键词： onychomycosis Kerasal Nail Asian Topical 4 Weeks

A Promising Strategy for the Treatment of onychomycosis with Curcumin and Photodynamic Therapy

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Journal of Pharmacy and Pharmacology 2015年第9期3卷 434-437页

作者： Ana Paula da Silva Fernanda M. Carbinatto Vanderlei S. Bagnato Natalia M. Inada University of Sao Paulo Physics Institute of Sao Carlos 13566-590 Sao Carlos SP Brazil

onychomycosis is a disease of high incidence in the nail plate and responsible for approximately half of the cases of nail infections. Conventionally, dermatologists prescribe antibiotics and antifungals for long periods for its treatment. The high incidence of this type of infection and the increase of microbial strains resistant to the available drugs have justified the importance of the development of new technologies and treatments. This paper presents the photodynamic therapy as an alternative treatment of onychomycosis. New strategies for the use of curcumin as a photosensitizer and its therapeutic response were investigated in different formulations （gel and emulsion）. Photodynamic therapy is a promising technique by which microorganisms are eliminated by a photosensitizing compound, light and oxygen. It was evaluated in two patients who had developed lesions in the fmgernails caused by onychomycosis for approximately 10 years. The lesions were treated by photodynamic therapy with curcumin. The therapeutic efficacy was observed after a maximum of six photodynamic therapy sessions without any other adjuvant therapy. Curcumin has become more promising than the therapeutic standard as it is a natural and versatible drug for incorporation in different formulations, at low cost and low probability of side effects.

关键词： onychomycosis photodynamic therapy curcumin formulations.

Proximal White onychomycosis in an Immunocompetent Patient: A Case Report

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Case Reports in Clinical Medicine 2015年第1期4卷 41-44页

作者： Brian M. Schmidt Crystal Holmes Department of Podiatric Medicine and Surgery Yale New Haven Hospital/DVA West Haven New Haven CT USA Department of Internal Medicine University of Michigan Ann Arbor MI USA

Objective: onychomycosis is a diagnosis of fungal organisms in the nail unit. It frequently occurs in both the immunocompetent and immunocompromised patient. A variant of onychomycosis is proxiaml onychomycosis that occurs on the most proximal aspect of the nail. Proximal onychomycosis is known to be commonly associated with immunocompromised status. Study Design: A case report of a veteran who presented a dermatology clinic with complaint of solitary nail discoloration that was recalcitrant to over-the-counter therapy including topical hydrogen peroxide and foot soaks without improvement. Results and Conclusions: This individual case report demonstrates that pedal proximal onychomycosis can be associated with non-dermatophyte organisms, identified as Fusarium species, in immunocompetent individuals. The finding of pedal proximal onychomycosis caused by a Fusarium non-dermatophytic mold has not been reported. The veteran was successfully cured of the condition with treatment via oral terbinafine for a ninety-day course while monitoring patient’s liver function test for any complications.

关键词： Proximal onychomycosis Nail Fungus Onychcomycosis

Itraconazole and Nail Scraping in the Treatment of onychomycosis( A open trial of175 cases)

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Journal of Nanjing Medical University 2000年第1期14卷 45-47页

作者： Zhu Wenyuan(朱文元) Fan Weixin(范卫新) Zhou Baoquan(周宝泉) Zhang Meihua(张美华) Department of Dermatology, the First Affiliated Hospital, Nanjing Medical University,Nanjing 210029, P.R.China Department of Dermatology the First Affiliated HospitalNanjing Medical UniversityNanjing 210029P. R. China

Objective Itraconazole pulse therapy is at lest as efficient as itraconazole continuous treatment for onychomyocsis, but the long term oral antimycotic therapy has potential ***\ 40% urea paste was thickly applied to each affected nail which was dressed by three cloth adhesive tapes. The urea paste was changed every day or every other day for 5 to 7 days. The sick softened nails were scraped off thoroughly with razer blade. After sick nails were removed, all patients received 200 mg of itraconazole twice a day for seven consecutive days. Results\ Fingernail onychomycosis were cured in 93% (130/140), markedly improved in 6.4% (9/140). Toenail onychomycosis were cured in 82% (29/35), markedly improved in 17.1(6/35). And in a 18 month follow up period, 16(10 2%) of 147 patients had relapses. Conclusion\ The treatment of onychomycosis with oral itraconazole plus nail scraping is as effective as that of itraconazole pulse therapy but has less side effect and lower cost.\;

关键词： onychomycosis itraconazole urea paste

Early and Visible Improvements after Application of K101 in the Appearance of Nails Discoloured and Deformed by onychomycosis

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Journal of Cosmetics, Dermatological Sciences and Applications 2011年第3期1卷 59-63页

作者： Jan Faergemann Soren Gullstrand Kjell Rensfeldt Department of Dermatology Sahlgrenska University HospitalGothenburgSweden Mollevangens Huslakargrupp MalmoSweden Moberg Derma AB BrommaSweden

onychomycosis is a fungal infection of the nails of the fingers and toes and is difficult to cure. A previous 24-week, placebo-controlled study demonstrated that a solution containing propylene glycol, urea and lactic acid (K101) was well-tolerated and effective in the treatment of onychomycosis. Patients who received K101 judged that their condition had improved from Week 2 of treatment onwards. The aim of the current study was to further evaluate and document early visible effects on nail appearance after application of topical K101 in an 8-week baseline-controlled study in 75 patients. Patients graded the appearance of their nail compared with baseline using a four-point scale. Compared with baseline, 91.8% (67/73;95% confidence interval (CI): 83.0%, 96.9%) of the patients experienced at least some improvement in their target nail after 8 weeks of treatment. At Week 2, the proportion showing some improvement was 76.7% (56/73;95% CI: 65.4%, 85.8%) with this number increasing to 87.7% (64/73;95% CI: 77.9%, 94.2%) at Week 4. Proportions of patients reporting less thickened, less discoloured, less brittle and softer nails increased over the course of the study. No safety issues were identified. In conclusion, K101 provided early visible improvements in nails affected by onychomycosis.

关键词： K101 onychomycosis Early Effects Topical

Advance in application of dermoscopy for onychomycosis diagnosis

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International Journal of Dermatology and Venereology 2019年第1期2卷 19-23页

作者： Xiao Liu Zhi-Yuan Yao Department of Dermatology and Venereology China-Japan Friendship Clinical Medical College of Peking UniversityBeijing 100029China

Introductiononychomycosis refers to all kinds of fumgal infections of nail plate and nail bed,including those caused by dermatophytes,non-dermatophytes,and Candida species[1].onychomycosis is the most common nail disease in adults,accounting for 10%-30% of all infectious diseases,and 50% of all nail disorders[2-5].The most common tests used to diagnose onychomycosis are direct microscopic examination,mycological culture,histopathologic examination,and polymerase chain reaction-based tests[2,6].Because of the special structure of the sampling area,patients often experience pain during nail abrasion for the collection of ***,the sensitivity of onychomycosis diagnosis is not satisfied.

关键词： pplication onychomycosis diagnosis examination