Long-pulse Nd：YAG 1064-nm laser treatment for onychomycosis

作     者：ZHANG Rui-na WANG Dong-kun ZHUO Feng-lin DUAN Xiao-han ZHANG Xiao-yan ZHAO Jun-ying 

作者机构：Department of Dermatology Beijing Friendship Hospital CapitalMedical University China Beijing 100050 Department of Dermatology China-Japan Friendship Hospital China Beijing 100029 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2012年第125卷第18期

页      面：3288-3291页

核心收录：

学科分类：13[艺术学] 1302[艺术学-音乐与舞蹈学] 

主　　题：onychomycosis laser, treatment 

摘      要：Background Recent research shows that lasers can inhibit fungal growth and that Nd：YAG 1064-nm lasers can penetrate as deep as the lower nail plate. The aim of this study was to observe the effect of a long-pulse Nd：YAG 1064-nm laser on 154 nails of 33 patients with clinically and mycologically proven onychomycosis. Methods Thirty-three patients with 154 nails affected by onychomycosis were randomly assigned to two groups, with the 154 nails divided into three sub-groups （Ⅱ degree,Ⅲ degree, and IV degree） according to the Scoring Clinical Index of Onychomycosis. The 15 patients （78 nails） in group 1 were given eight sessions with a one-week interval, and the 18 patients （76 nails） in group 2 were given four sessions with a one-week interval. Results In group 1, the effective rates at 8 weeks, 16 weeks, and 24 weeks were 63%, 62%, and 51%, respectively, and the effective rates in group 2 were 68%, 67%, and 53% respectively. The treatment effect was not significantly different between any sub-group pair （P 〉0.05）. Conclusions Long pulse Nd：YAG 1064-nm laser was effective for onychomycosis. It is a simple and effective method without significant complications or side effects and is expected to become an alternative or replacement therapy for onychomycosis.