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Effectiveness and safety of COVID-19 vaccines in patients with oncological diseases:State-of-the-art

World Journal of Clinical Oncology 2023年第9期14卷 343-356页

作者： Nedelcho Ivanov Boris Krastev Dimitrina Georgieva Miteva Hristiana Batselova Radostina Alexandrova Tsvetelina Velikova Department of Clinical Immunology with Stem Cell Bank University Hospital AlexanrovskaSofia 1431Bulgaria Medical Center Nadezhda Medical Center NadezhdaSofia 1407Bulgaria Department of Genetics Faculty of BiologySofia University St.Kliment OhridskiSofia 1164Bulgaria Department of Epidemiology and Disaster Medicine Medical UniversityPlovdivUniversity Hospital St.GeorgePlovdiv 6000Bulgaria Department of Pathology Institute of Experimental MorphologyPathology and Anthropology with MuseumBulgarian Academy of SciencesSofia 1000Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria

Although the coronavirus disease 2019(COVID-19)pandemic was declared to be no longer“a public health emergency of international concern”with its wide range of clinical manifestations and late complications,severe acute respiratory syndrome coronavirus 2 infection proved to be a serious threat,especially to the elderly and patients with *** with oncologic diseases are vulnerable to severe infection and ***,patients with oncohematological diseases have a higher risk of severe COVID-19 and impaired post-vaccination ***,cancer patients are usually excluded from vaccine trials and investigations of post-vaccinal immune responses and the effectiveness of the *** aimed to elucidate to what extent patients with cancer are at increased risk of developing severe COVID-19 and what is their overall case fatality *** also present the current concept and evidence on the effectiveness and safety of COVID-19 vaccines,including boosters,in oncology *** conclusion,despite the considerably higher mortality in the cancer patient group than the general population,countries with high vaccination rates have demonstrated trends toward improved survival of cancer patients early and late in the pandemic.

关键词： COVID-19 COVID-19 vaccines RNA vaccines Cancer oncological Safety Efficacy Immunogenicity

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Radical prostatectomy in patients aged 75 years or older:review of the literature

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Asian Journal of Andrology 2019年第1期21卷 32-36页

作者： Philipp Mandel Thenappan Chandrasekar Felix K Chun Hartwig Huland Derya Tilki Martini-Klinik Prostate Cancer Center University Hospital Hamburg-EppendorfHamburg 20246Germany Division of Urology Department of Surgical Oncology Princess Margaret Cancer CentreUniversity Health Network and the University of TorontoTorontoOntario M5G 2M9Canada Department of Urology University Hospital Hamburg-EppendorfHamburg 20246Germany

Given the demographic trends toward a considerably longer life expectancy,the percentage of elderly patients with prostate cancer will increase further in the upcoming ***,the question arises,should patients ≥75 years old be offered radical prostatectomy and under which circumstances? For treatment decision-making,life expectancy is more important than biological *** a result,a patient's health and mental status has to be determined and radical treatment should only be offered to those who are *** perioperative morbidity and mortality in these patients is increased relative to younger patients,patient selection according to comorbidities is a key issue that needs to be *** is known from the literature that elderly men show notably worse tumor characteristics,leading to worse oncologic outcomes after ***,elderly patients also demonstrate worse postoperative recovery of continence and erectile *** the absolute rates of both oncological and functional outcomes are still very reasonable in patients ≥75 years,a radical prostatectomy can be offered to highly selected and healthy elderly patients. Nevertheless,patients clearly need to be informed about the worse outcomes and higher perioperative risks compared to younger patients.

关键词： age functional outcome oncological outcome prostate cancer radical prostatectomy

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Low rectal cancer:Sphincter preserving techniques-selection of patients,techniques and outcomes

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World Journal of Gastrointestinal Oncology 2015年第7期7卷 55-70页

作者： Nikoletta Dimitriou Othon Michail Dimitrios Moris John Griniatsos 1st Department of Surgery University of AthensMedical SchoolLaiko Hospital

Low rectal cancer is traditionally treated by abdominoperineal resection. In recent years, several new techniques for the treatment of very low rectal cancer patients aiming to preserve the gastrointestinal continuity and to improve both the oncological as well as the functional outcomes, have been emerged. Literature suggest that when the intersphincteric resection is applied in T1-3 tumors located within 30-35 mm from the anal verge, is technically feasible, safe, with equal oncological outcomes compared to conventional surgery and acceptable quality of life. The Anterior Perineal Plan E for Ultra-low Anterior Resection technique, is not disrupting the sphincters, but carries a high complication rate, while the reports on the oncological and functional outcomes are limited. Transanal Endoscopic Micro Surgery(TEM) and Trans Anal Minimally Invasive Surgery(TAMIS) should represent the treatment of choice for T1 rectal tumors, with specific criteria according to the NCCN guidelines and favorable pathologic features. Alternatively to the standard conventional surgery, neoadjuvant chemo-radiotherapy followed by TEM or TAMIS seems promising for tumors of a local stage T1sm2-3 or T2. Transanal Total Mesorectal Excision should be performed only when a board approved protocol is available by colorectal surgeons with extensive experience in minimally invasive and transanal endoscopic surgery.

关键词： Low rectal cancer Sphincter preservingsurgery Intersphincteric resection Anterior PerinealPlanE for Ultra-low Anterior Resection of the Rectum Total mesorectal excision TransAnal Minimally InvasiveSurgery Transanal Total Mesorectal Excision Quality oflife oncological outcome Functional outcome

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Rectal cancer and Fournier's gangrene- current knowledge and therapeutic options

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World Journal of Gastroenterology 2015年第30期21卷 9002-9020页

作者： Tomislav Bruketa Matea Majerovic Goran Augustin Department of Surgery University Hospital Center Zagreb Department of Internal Medicine University Hospital Center Zagreb Department of Surgery Division of Gastroin- testinal SurgeryUniversity Hospital Center Zagreb School of Medicine University of Zagreb

Fournier's gangrene(FG) is a rapid progressive bacterial infection that involves the subcutaneous fascia and part of the deep fascia but spares the muscle in the scrotal,perianal and perineal region. The incidence has increased dramatically,while the reported incidence of rectal cancer-induced FG is unknown but is extremely low. Pathophysiology and clinical presentation of rectal cancer-induced FG per se does not differ from the other causes. Only rectal cancer-specific symptoms before presentation can lead to the diagnosis. The diagnosis of rectal cancer-induced FG should be excluded in every patient with blood on digital rectal examination,when urogenital and dermatological causes are excluded and when fever or sepsis of unknown origin is present with perianal symptomatology. Therapeutic options are more complex than for other forms of FG. First,the causative rectal tumor should be removed. The survival of patients with rectal cancer resection is reported as 100%,while with colostomy it is 80%. The preferred method of rectal resection has not been defined. Second,oncological treatment should be administered but the timing should be adjusted to the resolution of the FG and sometimes for the healing of plastic reconstructive procedures that are commonly needed for the reconstruction of large perineal,scrotal and lower abdominal wall defects.

关键词： Fournier's gangrene Necrotizing fasciitis Proctological examination Necrotizing soft tissueinfections oncological treatment Rectal cancer Surgical treatment Reconstructive surgery

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Resection of multiple rectal carcinoids with transanal endoscopic microsurgery:Case report

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World Journal of Gastroenterology 2015年第7期21卷 2220-2224页

作者： Jiao-Lin Zhou Guo-Le Lin Da-Chun Zhao Guang-Xi Zhong Hui-Zhong Qiu Department of General Surgery Peking Union Medical College Hospital Department of Pathology Peking Union Medical College Hospital Department of Ultrasound Peking Union Medical College Hospital

Multiple rectal carcinoids are *** to the unreliability of endoscopic polypectomy in treating these submucosal lesions,a laparotomy is usually *** present a case report on multiple rectal carcinoids with three carcinoid foci<10 mm in diameter located in the *** examination showed the lesions to be confined to the submucosal layer with no perirectal nodal involvement.A transanal endoscopic microsurgerywas successfully performed to remove the three lesions with accurate full-thickness resection followed by secured suture *** postoperative pathology revealed neuroendocrine tumors G1(carcinoids)located within the submucosal layer without lymphatic or vessel *** the deep and lateral surgical margins were completely free of tumor *** patient recovered quickly and *** tumor recurrence was observed at the six-month *** the multiple small rectal carcinoids without muscularis propria or lymphatic invasion,transanal endoscopic microsurgery offers a reliable and efficient alternative approach to traditional laparotomy for select patients,with the added advantages of minimally invasive surgery.

关键词： Colorectal Gastrointestinal surgery oncological su

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Soft tissue defects of the hand:etiology and classification

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Plastic and Aesthetic Research 2023年第1期10卷 381-388页

作者： Bruno Battiston Camillo Fulchignoni U.O.C Orthopaedics Traumatology and Hand SurgeryU.O.D.MicrosurgeryC.T.O.HospitalTurin 10126Italy Orthopedics&Hand Surgery Unit Department of OrthopedicsFondazione Policlinico Universitario A.GemelliIRCCS-Catholic University of the Sacred HearthRome 00168Italy

Soft tissue defects of the hand may result from trauma,oncological procedures,or severe *** etiologies have been *** all cases,an accurate clinical examination is mandatory to understand which structures are involved and what must be *** can be helpful to simplify the decision-making process to classify these ***,there is no consensus on which classification is best to be used among those described in the *** review presents the most common ones,differentiating those classically used to describe tissue loss consequential to a traumatic event from those used to classify soft tissue defects consequent to other events.

关键词： Soft tissue defect trauma oncological infection tissue loss

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Oncoplastic Breast Surgery after Neoadjuvant Chemotherapy Replacing Mastectomy in Locally Advanced Breast Cancer (LABC): Single Institute Experience

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Journal of Cancer Therapy 2017年第11期8卷 1058-1067页

作者： Yasser El Ghamrini Ahmed Morad Hossam Elsadek Ahmed Ezzat General Surgery Department Ain Shams University Cairo Egypt Clinical Oncology Department Ain Shams University Cairo Egypt

Background: Integration of neoadjuvant chemotherapy (NCT) in early 70s resulted that many LABC tumors become resectable but with total mastectomy especially those with partial response, oncoplastic techniques give better oncological outcome with better cosmetic results. Objective: We evaluate the oncological safety of oncoplastic breast surgery (OS) in LABC showing partial response to NCT. Methods: We prospectively analyzed the data of 32 out of 58 patients with LABC who showed partial response to NCT and could have conservative surgery with advanced oncoplastic techniques rather than total mastectomy. Results: Out of 58 patients with LABC, received neoadjuvant chemotherapy, complete response was observed in 8 patients (13%), partial response reported in 32 (55.1%) cases, 12 patients (20%) had stable disease and 6 patients (10%) showed progressive disease. Data of 32 cases were studied (mean age 44.84 ± 9.10 years;range 26 - 59 years). Inferior pedicle was performed in 9 cases, mini LD flap in 3 patients, 5 had Grissotti technique, 6 with superomedial pedicle, 4 had V mammoplasty and 3 with J mammoplasty and 2 had vertical mammoplasty. Margins were positive in 5 cases (15.6%) with mean margin width 9.63 ± 5.72 (range 0 - 22 mm), and the local recurrence was reported in 2 cases (6.2%). Complications were reported in 3 cases (9.3%). The follow up was 1.67 ± 1.03 (range 0 - 3.3 years). Conclusions: Integration of neoadjuvant chemotherapy together with advanced oncoplastic techniques opens a new way for management of LABC especially those showing partial response with avoidance of total mastectomy, and comparable oncological safety in addition to better aesthetic and psychological outcome.

关键词： Locally Advanced Breast Cancer Oncoplastic Surgery oncological Safety Neoadjuvant Chemotherapy

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Preoperative colonic stents vs emergency surgery for acute left-sided malignant colonic obstruction: meta-analysis with systematic review of the literature

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World Journal of Meta-Analysis 2017年第1期5卷 1-13页

作者： Belinda De Simone Fausto Catena Federico Coccolini Salomone Di Saverio Massimo Sartelli Arianna Heyer Nicola De Angelis Gian Luigi De Angelis Luca Ansaloni Department of Emergency and Trauma Surgery University Hospital of Parma Department of General and Emergency Surgery Papa XXIII Hospital Department of General Surgery Maggiore Hospital of Bologna Department of Emergency and General Surgery Macerata’s Hospital Department of Medical Sciences University of California Liver Transplantation and General Surgery Unit Henry Mondor Hospital Department of Gastroenterology University Hospital of Parma

AIM To investigate by meta-analytic study and systematic review, advantages of colonic stent placement in comparison with emergency *** We conducted an extensive literature search by PubMed, Google Scholar, Embase and the Cochrane Libraries. We searched for all the papers in English published till February 2016, by applying combinations of the following terms: Obstructive colon cancer, colon cancer in emergency, colorectal stenting, emergency surgery for colorectal cancer, guidelines for obstructive colorectal cancer, stenting vs emergency surgery in the treatment of obstructive colorectal cancer, selfexpanding metallic stents, stenting as bridge to surgery. The study was designed following the PrismaStatement. By our search, we identified 452 studies, and 57 potentially relevant studies in full-text were reviewed by 2 investigators; ultimately, 9 randomized controlled trials were considered for meta-analysis and all the others were considered for systematic *** In the meta-analysis, by comparing colonic stenting(CS) as bridge to surgery and emergency surgery, the pooled analysis showed no significant difference between the two techniques in terms of mortality [odds ratio(oR) = 0.91], morbidity(oR = 2.38) or permanent stoma rate(oR = 1.67); primary anastomosis was more frequent in the stent group(oR = 0.45; P = 0.004) and stoma creation was more frequent in the emergency surgery group(oR = 2.36; P = 0.002). No statistical difference was found in disease-free survival and overall survival. The pooled analysis showed a significant difference between the colonic stent and emergency surgery groups(oR = 0.37), with a significantly higher 1-year recurrence rate in the stent group(P = 0.007).CONCLUSION CS improves primary anastomosis rate with significantly high 1-year follow-up recurrence and no statistical difference in terms of disease-free survival and overall survival.

关键词： Colonic stent Self-expandable metallic stent Obstructive left colon cancer Emergency surgery Endo-laparoscopic approach oncological outcome

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A primitive approach to Ou MC decrescendo phenomenon with a hands-on therapy—The relation between human bilateral symmetry and disease

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Natural Science 2014年第2期6卷 88-98页

作者： Ming Cheh Ou Dennis Ou Chung Chu Pang Department of Gynecology and Obstetrics Su Women Hospital Taipei City Taiwan Department of Gynecology and Obstetrics Taipei City Hospital Taipei City Taiwan Department of Gynecology and Obstetrics Taipei Medical University Taipei City Taiwan Department of Mechanical Engineering and Biomedical Engineering Carnegie Mellon University Pittsburgh USA

The Ou MC decrescendo phenomenon (OuDP) involves the placing of the contralateral hand of the examiner on the acute abdomen of female patients (Ou MC manipulation), which results in an alleviation of pain [1]. Two front-end observations showed that placement of the contralateral hand on the acute abdomen of women alleviated pain (78 of 81 women or 96.3%), while placement of the ipsilateral hand did not (0 of 39 women or 0%). This method named as Ou MC handing remedy (HR) was used to observe the immediate and cumulative effects of OuDP on 38 cases, of which 27 were self-administered and 11 were administered by the therapist. The mean age of the patients was 55.8 years (standard deviation, 22.9 years). Five minutes after initial self-administered HR, there was pain alleviation in 14 cases and symptoms or signs beyond pain improved for another 6 cases while 7 cases unevaluated. Final results showed 9 cured, 5 with partial remission and the remaining 13 with complete remission. Five minutes after initial therapist-administered HR, pain alleviation was found with 10 cases while 1 case unevaluated. The final results showed 7 cases cured, 2 with partial remission, and 2 with complete remission. The resolution of non-infectious conditions (23/ 38) with OuDP is consistent with the restoration of normal tissue function, which seems to contribute to pain alleviation and defense against infections and tumors. Interestingly, the OuDP is capable of being invoked by either the patient or the therapist. These findings warrant further investigation.

关键词： Ou MC Decrescendo Phenomenon Pain Inflammation oncological Change Hands-On Treatment Restoration of Normal Tissue Function

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Theranostic applications:Non-ionizing cellular and molecular imaging through innovative nanosystems for early diagnosis and therapy

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World Journal of Radiology 2011年第10期3卷 249-255页

作者： Sergio Casciaro National Council of Research Institute of Clinical PhysiologyBioengineering DivisionCampus Universitario EcotekneVia per Monteroni73100 LecceItaly

Modern medicine is expanding the possibilities of receiving "personalized" diagnosis and therapies,providing minimal invasiveness,technological solutions based on non-ionizing radiation,early detection of pathologies with the main objectives of being operator independent and with low cost to *** research activities aim to strongly contribute to these trends by improving the capabilities of current diagnostic imaging systems,which are of key importance in possibly providing both optimal diagnosis and therapies to *** medical diagnostics,cellular imaging aims to develop new methods and technologies for the detection of specific metabolic processes in living organisms,in order to accurately identify and discriminate normal from pathological *** fact,most diseases have a "molecular basis" that detected through these new diagnostic methodologies can provide enormous benefits to ***,this possibility is mainly related to the use of Positron Emission Tomography,with an exposure to ionizing radiation for patients and operators and with extremely high medical *** future possible development of non-ionizing cellular imaging based on techniques such as Nuclear Magnetic Resonance or Ultrasound,would represent an important step towards modern and personalized *** the last decade,the field of nanotechnology has made important progress and a wide range of organic and inorganic nanomaterials are now available with an incredible number of further combinations with other compounds for cellular *** availability of these new advanced nanosystems allows new scenarios in diagnostic methodologies which are potentially capable of providing morphological and functional information together with metabolic and cellular indications.

关键词： Intelligent nanosystems for cellular targeting Magnetic resonance and ultrasound Molecular imaging Non-ionizing diagnostic techniques Personalized medicine in the oncological and vascular field

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