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Unveiling the molecular and cellular links between obstructive sleep apnea-hypopnea syndrome and vascular aging

中华医学杂志(英文版) 2025年第2期

作者： Liu Wei Zhang Le Liao Wenhui Liu Huiguo Liang Wukaiyang Yan Jinhua Huang Yi Jiang Tao Wang Qian Zhang Cuntai Department of Geriatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. Jiefang Avenue Wuhan Hubei China Key Laboratory of Vascular Aging Ministry of Education Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. Jiefang Avenue Wuhan Hubei China Institute of Gerontology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. Jiefang Avenue Wuhan Hubei China Department of Respiratory and Critical Care Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. Jiefang Avenue Wuhan Hubei China

Vascular aging (VA) is a common etiology of various chronic diseases and represents a major public health concern. Intermittent hypoxia (IH) associated with obstructive sleep apnea-hypopnea syndrome (OSAHS) is a primary pathological and physiological driver of OSAHS-induced systemic complications. A substantial proportion of OSAHS patients, estimated to be between 40% and 80%, have comorbidities such as hypertension, heart failure, coronary artery disease, pulmonary hypertension, atrial fibrillation, aneurysm, and stroke, all of which are closely associated with VA. This review examines the molecular and cellular features common to both OSAHS and VA, highlighting decreased melatonin secretion, impaired autophagy, increased apoptosis, increased inflammation and pyroptosis, increased oxidative stress, accelerated telomere shortening, accelerated stem cell depletion, metabolic disorders, imbalanced protein homeostasis, epigenetic alterations, and dysregulated neurohormonal signaling. The accumulation and combination of these features may underlie the pathophysiological link between OSAHS and VA, but the exact mechanisms by which OSAHS affects VA may require further investigation. Taken together, these findings suggest that OSAHS may serve as a novel risk factor for VA and related vascular disorders, and that targeting these features may offer therapeutic potential to mitigate the vascular risks associated with OSAHS.

关键词： obstructive sleep apnea-hypopnea syndrome Vascular aging Intermittent hypoxia Molecular and cellular mechanisms

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Altered Cortical Information Interaction During Respiratory Events in Children with obstructive sleep apnea-hypopnea syndrome

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Neuroscience Bulletin 2024年第10期40卷 1458-1470页

作者： Jin Chen Minmin Lin Naikai Shi Jingxian Shen Xuchu Weng Feng Pang Jiuxing Liang Key Laboratory of Brain Cognition and Education ScienceMinistry of EducationChinaInstitute for Brain Research and RehabilitationGuangdong Key Laboratory of Mental Health and Cognitive ScienceSouth China Normal UniversityGuangzhou 510631China School of General Education Guangzhou Huali CollegeGuangzhou 511325China Department of sleep Medicine The Sixth Affliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Otorhinolaryngology Head and Neck SurgeryThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China TUM-Neuroimaging Center Technical University of Munich81675 MunichGermany Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument Sun Yat-Sen UniversityGuangzhou 510006China Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China

obstructive sleep apnea-hypopnea syndrome(OSAHS)significantly impairs children's growth and *** study aims to elucidate the pathophysiological mechanisms underlying OSAHS in children,with a particular focus on the alterations in cortical information interaction during respiratory *** analyzed sleep electroencephalography before,during,and after events,utilizing Symbolic Transfer Entropy(STE)for brain network construction and information flow *** results showed a significant increase in STE after events in specific frequency bands during N2 and rapid eye movement(REM)stages,along with increased STE during N3 stage ***,a noteworthy rise in the information flow imbalance within and between hemispheres was found after events,displaying unique patterns in central sleep apnea and ***,some of these alterations were correlated with symptom *** findings highlight significant changes in brain region coordination and communication during respiratory events,offering novel insights into OSAHS pathophysiology in children.

关键词： obstructive sleep apnea-hypopnea syndrome Children Respiratory events Electroencephalogram Effective connectivity-Symbolic transfer entropy

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obstructive sleep apnea-hypopnea syndrome immunological relationship

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World Journal of Clinical Cases 2024年第27期12卷 6011-6014页

作者： Mahmoud Ali Alaa Ramadan Salim Surani Department of Medicine Al-Azhar UniversityDamietta 11651Egypt Department of Medicine South Valley UniversityQena 83523Egypt Department of Medicine and Pharmacology Texas A&M UniversityCollege StationTX 77843United States Department of Anesthesiology Mayo ClinicRochesterMN 55905United States

obstructive sleep apnea-hypopnea syndrome(OSAHS)is a complex disorder cha-racterized by symptoms resulting from intermittent hypoxia and hypopnea,with research indicating a crucial role of immune system dysregulation and genetic variations in its pathogenesis.A recent Zhao et al study utilizes Mendelian ran-domization analysis to explore the causal relationship between immune cell characteristics and *** study identifies specific lymphocyte subsets as-sociated with OSAHS,providing valuable insights into the disease's pathophy-siology and potential targets for therapeutic *** findings underscore the significance of genetic and immunological factors in sleep disorders,offering a fresh perspective on OSAHS's *** to existing literature,Zhao et al's study stands out for its focus on genetic markers and specific immune responses associated with OSAHS,expanding upon previous research primarily centered on systemic *** conclusion,the study represents a signi-ficant advancement in the field,shedding light on the causal role of immune cells in OSAHS and paving the way for future research and targeted treatments.

关键词： obstructive sleep apnea Mendelian randomization Lymphocyte charac-teristics Immunology obstructive sleep apnea-hypopnea syndrome

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Effect of motivational interviewing on postoperative weight control in patients with obstructive sleep apnea-hypopnea syndrome

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World Journal of Clinical Cases 2020年第15期8卷 3209-3217页

作者： Xiang-Hong Sun Peng-Shi Xue Xiang-Xiu Qi Ling Fan Department of Critical Care Medicine Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Cardiology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Nursing Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Obesity is an important factor to cause the obstructive sleep apnea-hypopnea syndrome(OSAHS).Higher body mass index(BMI)often results in more severe ***,the common measures for controlling the weight mainly include diet control,increase exercise and so *** interviewing(MI)could explore the patient’s internal state and make the patient realize his/her ambivalence,resulting in the change in his/her *** process emphasizes respecting the patient’s *** To evaluate the effect of MI on the weight control of patients with *** A randomized controlled study was conducted in 100 obese OSAHS patients undergoing surgical treatment at Shengjing Hospital of China Medical *** patients were divided into an intervention group and a control group,with 50 cases *** control group was given routine health education after the operation;in addition to the regular health education,the intervention group was given MI according to a predetermined ***-related indicators,postoperative complications,and the sleep status of both groups were evaluated before and 6 mo after the *** Patients in the intervention group had significantly improved body weight,BMI,and waist and neck circumferences compared with patients in the control group(Psleepiness Scale and Self-Rating Scale of sleep scores of patients in the intervention group were significantly lower than those in the control group,and the sleep status of patients in the intervention group was improved(P<0.05).CONCLUSION MI intervention has a significant advantage over postoperative routine health *** can greatly change the lifestyle,further control the postoperative weight,reduce the occurrence of complications,improve the

关键词： obstructive sleep apnea-hypopnea syndrome Postoperative Weight control Motivational interview Quality of sleep Patients

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Intermittent hypoxia is involved in gut microbial dysbiosis in type 2 diabetes mellitus and obstructive sleep apnea-hypopnea syndrome

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World Journal of Gastroenterology 2022年第21期28卷 2320-2333页

作者： Sha-Sha Tang Cheng-Hong Liang Ya-Lei Liu Wei Wei Xin-Ru Deng Xiao-Yang Shi Li-Min Wang Li-Jun Zhang Hui-Juan Yuan Department of Endocrinology Henan Provincial Key Medicine Laboratory of Intestinal Microecology and DiabetesHenan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhou 450003Henan ProvinceChina

BACKGROUND obstructive sleep apnea(OSA)-hypopnea syndrome(OSAHS)has been recognized as a comorbidity of type 2 diabetes mellitus(T2DM);more than half of T2DM patients suffer from *** hypoxia(IH)plays an important role in metabolic diseases,such as obesity and OSAHS,through various mechanisms,including altering the gut microecological composition and ***,it is important to study the role of gut microbiota in T2DM patients with OSAHS,which has a high incidence and is prone to several *** To assess whether IH is involved in altering the fecal microbiome in T2DM patients with *** Seventy-eight participants were enrolled from Henan Province People’s Hospital and divided into healthy control(HC,n=26),T2DM(n=25),and T2DM+OSA(n=27)groups based on their *** fecal bacterial DNA of the research participants was extracted and subjected to 16S ribosomal RNA *** clinical indices,such as insulin resistance index,homocysteine(HCY)concentration,and the concentrations of inflammatory factors in the peripheral blood,were assessed and *** Group T2DM+OSA had the highest apnea-hypopnea index(AHI)(2.3 vs 3.7 vs 13.7),oxygen desaturation index(0.65 vs 2.2 vs 9.1),HCY concentration(9.6μmol/L vs 10.3μmol/L vs 13.81μmol/L)and C-reactive protein(CRP)concentrations(0.3 mg/L vs 1.43 mg/L vs 2.11 mg/L),and lowest mean oxygen saturation(97.05%vs 96.6%vs 94.7%)among the three *** and fifteen key differences in amplicon sequence variants were identified when comparing group T2DM+OSA with groups T2DM and HC,*** found progressively decreased levels of Faecalibacterium,Eubacterium,and Lachnospiraceae,and an increase in the level of Actinomyces,which strongly correlated with the HCY,CRP,fasting plasma glucose,and hemoglobin A1c concentrations,AHI,mean oxygen saturation,and insulin resistance index in group T2DM+OSA(P<0.05).CONCLUSION For T2DM patients with OSAHS,IH may be involved in selective

关键词： Gut microbiota obstructive sleep apnea-hypopnea syndrome Type 2 diabetes mellitus Intermittent hypoxia obstructive sleep apnea

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Clinical efficacy and mechanism study of mid-frequency anti-snoring device in treating moderate obstructive sleep apnea-hypopnea syndrome

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World Journal of Clinical Cases 2024年第5期12卷 942-950页

作者： Bao Qian Zhan-Jun Chen Yong-Sheng Wang Xiao-Yan Hu Xiao-Biao Hu Yong-Hua Zheng Pulmonary Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China Radiology Medicine Shanghai Jinshan Tinglin HospitalShanghai 201505China

BACKGROUND obstructive sleep apnea-hypopnea syndrome(OSAHS)is primarily caused by airway obstruction due to narrowing and blockage in the nasal and nasopha-ryngeal,oropharyngeal,soft palate,and tongue base *** mid-frequency anti-snoring device is a new technology based on sublingual nerve *** principle is to improve the degree of oropharyngeal airway stenosis in OSAHS patients under mid-frequency wave ***,there is a lack of clinical application and imaging *** We selected 50 patients diagnosed with moderate OSAHS in our hospital between July 2022 and August *** underwent a 4-wk treatment regimen involving the mid-frequency anti-snoring device during nighttime *** the treatment,we monitored and assessed the sleep apnea quality of life index and Epworth sleepiness Scale ***,we performed computed tomo-graphy scans of the oropharynx in the awake state,during snoring,and while using the mid-frequency anti-snoring ***-sectional area measurements in different states were taken at the narrowest airway point in the soft palate posterior and retrolingual *** Compared to pretreatment measurements,patients exhibited a significant reduction in the apnea-hypopnea index,the percentage of time with oxygen saturation below 90%,snoring frequency,and the duration of the most prolonged apnea *** lowest oxygen saturation showed a notable increase,and both sleep apnea quality of life index and Epworth sleepiness Scale scores *** computed tomography scans revealed that in OSAHS patients cross-sectional areas of the oropharyngeal airway in the soft palate posterior area and retrolingual area decreased during snoring compared to the awake ***,during mid-frequency anti-snoring device treatment,these areas increased compared to *** The mid-frequency anti-snoring device demonstrates the potential to enhance various sleep parameters in pat

关键词： Mid-frequency anti-snoring device obstructive sleep apnea-hypopnea syndrome sleep monitoring Oropharyngeal computed tomography Curative effect

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Analysis of the characteristics of coronary artery lesions in patients with obstructive sleep apnea-hypopnea syndrome and influencing factors

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Family Medicine and Community Health 2014年第4期2卷 41-47页

作者： Bin Sun Jing Liu Ding Huang Cheng Liu The Second Department of Cardiology the First Affiliated Hospital of Xinjiang Medical UniversityUrumchi830054XinjiangChina

Objective:The current study involved an analysis of the characteristics of coronary artery lesions of patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)and the correspond-ing influencing ***:One hundred twenty patients were selected by sleep apnea monitoring and coronary *** to the apnea-hypopnea index(AHI),the patients were divided into the following 3 groups:patients with an AHI15 times/h as the moderate-to-severe OSAHS group(n=63).The clinical and laboratory test data of patients in each group were collected.A single-factor ANOVA and multi-factor logistic regression analysis were performed on the study data to analyze the coronary artery lesions in patients with OSAHS and the corresponding influencing ***:(1)With respect to smoking,alcohol consumption,BMI,blood glucose,blood lipids,and blood pressure among the three groups,there were no significant differences between the three groups;however,age did differ among the three groups(P<0.05).(2)The incidence of anterior descending artery,right coronary artery,single-vessel,and coronary artery lesions as determined by coronary angiography was significantly different(P<0.05).The incidence of these vascular lesions in the moderate-to-severe group was higher than the mild group,and the incidence of coro-nary artery lesions in the moderate-to-severe group was higher(P<0.0167).(3)Based on multi-factor logistic regression analysis,alcohol consumption(OR=7.058;95%CI,1.953-25.508),age(OR=1.845;95%CI,1.121-3.038),and the AHI(OR=2.404;95%CI,1.088-5.314)were the major risk factors for coronary artery *** consumption(OR=12.114;95%CI,3.058-47.979)and the AHI(OR=3.052;95%CI,1.210-7.694)were the risk factors for single-vessel ***(OR=2.812;95%CI,1.236-6.400)was the major risk factor for multi-vessel ***:The probability

关键词： obstructive sleep apnea-hypopnea syndrome Coronary artery lesions

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Effect of Continuous Positive Airway Pressure Therapy on Glycemic Excursions and Insulin Sensitivity in Patients with obstructive sleep apnea-hypopnea syndrome and Type 2 Diabetes

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Chinese Medical Journal 2015年第17期128卷 2301-2306页

作者： Li-Xin Guo Xin Zhao Qi Pan Xue Sun Hui Li Xiao-Xia Wang Li-Na Zhang Yao Wang Department of Endocrinology Beijing Hospital Beijing 100730 China Department of General Medicine First Hospital of China Medical University Shenyang Liaoning 110001 China

Background： For patients with obstructive sleep apnea-hypopnea syndrome （OSAHS） and type 2 diabetes mellitus （T2DM）, the night sleep interruption and intermittent hypoxia due to apnea or hypopnea may induce glycemic excursions and reduce insulin sensitivity. This study aimed to investigate the effect of continuous positive airway pressure （CPAP） therapy in patients with OSAHS and T2DM. Methods： Continuous glucose monitoring system （CGMS） was used in 40 patients with T2DM and newly diagnosed OSAHS. The measurements were repeated after 30 days of CPAP treatment. Subsequently, insulin sensitivity and glycohemoglobin （HbAlc） were measured and compared to the pretreatment data. Results： After CPAP therapy, the CGMS indicators showed that the 24-h mean blood glucose （MBG） and the night time MBG were significantly reduced （P 〈 0.05 and P = 0.03, respectively）. The mean ambulatory glucose excursions （MAGEs） and the mean of daily differences were also significantly reduced （P 〈 0.05 and P = 0.002, respectively） compared to pretreatment levels. During the night, MAGE also significantly decreased （P = 0.049）. The differences between the highest and lowest levels of blood glucose over 24 h and during the night were significantly lower than prior to CPAP treatment （P 〈 0.05 and P = 0.024, respectively）. The 24 h and night time durations of high blood glucose （〉7.8 mmol/L and 〉 11.1 mmol/L） decreased （P 〈 0.05 and P 〈 0.05, respectively） after the treatment. In addition, HbA 1 c levels were also lower than those before treatment （P 〈 0.05）, and the homeostasis model assessment index of insulin resistance was also significantly lower than before CPAP treatment （P = 0.034）. Conclusions： CPAP therapy may have a beneficial effect on improving not only blood glucose but also upon insulin sensitivity in T2DM patients with OSAHS. This suggests that CPAP may be an effective treatment for T2DM in addition to intensive diabetes management.

关键词： Continuous Glucose Monitoring System Continuous Positive Airway Pressure obstructive sleep apnea-hypopnea syndrome Type 2 Diabetes Mellitus

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Relation between obstructive sleep apnea-hypopnea syndrome and Glaucoma in a Sub-Saharan African Population

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Open Journal of Ophthalmology 2021年第3期11卷 191-202页

作者： Christelle Domngang Ngambi Ferdinand Nanfack Chantal Mekieje Tumchou Pamela Kapche Diane Menanga Alain Parick Kagmeni Giles Faculty of Health Sciences Université des Montagnes Bangangté Cameroon Faculty of Medicine and Biomedical Sciences Université of Yaoundé 1 Yaounde Cameroon

Introduction: obstructive sleep apnea-hypopnea syndrome (OSAHS) is a frequent pathology worldwide whose main mechanism is a complete or partial obstruction of the upper airway. One of the pathophysiological mechanisms described in primary open-angle glaucoma is that hypoxia in the optic nerve progressively destroys the retinal cells leading to the onset and/or aggravation of glaucoma. The aim of the study was to evaluate the risk of OSA in patients with primary open-angle glaucoma. Methodology: An analytical study was conducted from January to May 2020 at the UHC. After obtaining ethical clearance, 112 patients including 50 glaucoma patients (44.64%) and 62 in the control group were enrolled. Sociodemographic and clinical data were collected from the medical records of the participants, with or without glaucoma, and a questionnaire was administered and a clinical examination performed. The STOP BANG score was used to determine the risk level of OSAHS. Statistical analyses were performed using Epi Info version 7.2. Results: A female predominance was found (60%) in the glaucoma group with a mean age of 55 ± 17 years against 49 ± 18 years in the control group. The high risk of OSAHS was more associated with glaucoma patients. In glaucoma patients, an association was found between high risk of OSAHS and snoring (OR = [1.43 - 849.53];p = 0.029) as well as insomnia (OR = [1.36 - 482.86];p = 0.030). Conclusion: High risk of OSAHS was found in participants with chronic open-angle glaucoma. Signs of OSAHS should be sought in chronic open-angle glaucoma as it may be a factor in its progression.

关键词： obstructive sleep apnea-hypopnea syndrome Glaucoma Risk Factor Subsaharan Africa

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Screening obstructive sleep apnea-hypopnea syndrome from snorers in children by heart rate variability analysis

Screening obstructive sleep apnea-hypopnea syndrome from sno...

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中国睡眠研究会第九届学术年会

作者： Yunxiao Wu Kunling Shen Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University Department of Respiratory Beijing Children's Hospital Capital Medical University

＜正＞This study aimed to evaluate the application of time-and frequency-domain analysis of heart rate variability（HRV）to screen obstructive sleep apnea-hypopnea syndrome（OSAHS）from snorers in *** children who were more than 3 years old were recruited and simultaneously underwent standard polysomnography（PSG）and 24 h ambulatory *** HRV variables of the two groups were compared,and a threshold value of the most significant variables

关键词： obstructive sleep apnea-hypopnea syndrome heart rate variability children

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