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Welding depth measurement for different mode lasers using optical coherence tomography

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Chinese Optics Letters 2024年第1期22卷 41-46页

作者：谢冠明王三宏张跃强李由胡彪傅愉于起峰 Institute of Intelligent optical Measurement and Detection Shenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Shenzhen Sincevision Technology Co. Ltd.Shenzhen 518055China National Key Laboratory of Human Factors Engineering China Astronaut Research and Training CenterBeijing 100094China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

optical coherence tomography(OCT)allows a direct and precise measurement of laser welding depth by coaxially measuring the keyhole depth and can be used for process monitoring and *** OCT measurement was taken during single-beam laser welding,the keyhole instability of aluminum welding resulted in highly scattered OCT data and complicated the welding depth extraction *** a combination of an inner core beam and an outer ring beam,a novel adjustable ring mode(ARM)laser for producing a stable keyhole was applied to the OCT *** ARM laser power arrangements were conducted on aluminum and *** results indicated that the ring beam greatly improved the stability of the core beam-induced keyhole,and smooth welding depth can be extracted from the concentrated OCT data.

关键词： optical coherence tomography adjustable ring mode laser laser welding welding depth

Deep learning-based inpainting of saturation artifacts in optical coherence tomography images

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Journal of Innovative optical Health Sciences 2024年第3期17卷 1-10页

作者： Muyun Hu Zhuoqun Yuan Di Yang Jingzhu Zhao Yanmei Liang Institute of Modern Optics Nankai UniversityTianjin Key Laboratory of Micro-scale Optical Information Science and TechnologyTianjin 300350China Department of Thyroid and Neck Tumor Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China

Limited by the dynamic range of the detector,saturation artifacts usually occur in optical coherence tomography(OCT)imaging for high scattering *** available methods are difficult to remove saturation artifacts and restore texture completely in OCT *** proposed a deep learning-based inpainting method of saturation artifacts in this *** generation mechanism of saturation artifacts was analyzed,and experimental and simulated datasets were built based on the *** super-resolution generative adversarial networks were trained by the clear–saturated phantom image *** perfect reconstructed results of experimental zebrafish and thyroid OCT images proved its feasibility,strong generalization,and robustness.

关键词： optical coherence tomography saturation artifacts deep learning image inpainting.

Reduced macular thickness and vascular density in abnormal glucose metabolism patients:A meta-analysis of optical coherence tomography(OCT)and OCT angiography studies

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Chinese Medical Journal 2024年第9期137卷 1054-1068页

作者： Xiangyu Fu Xiang Ren Wenyue Chen Danian Chen Department of Ophthalmology West China HospitalSichuan UniversityChengduSichuan 610041China Research Laboratory of Ophthalmology and Vision Sciences State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Ophthalmology The People’s Hospital of Guizhou ProvinceGuiyangGuizhou 550002China

Background:Alterations in macular thickness and vascular density before clinically visible diabetic retinopathy(DR)remain *** study aimed to determine whether retinal manifestations in abnormal glucose metabolism(AGM)patients differ from those in the healthy ***:PubMed,Embase,and Web of Science were searched between 2000 and *** eligibility criteria were AGM patients without *** and secondary outcomes measured by optical coherence tomography(OCT)and OCT angiography(OCTA)were analyzed and expressed as standardized mean differences(SMDs)with 95%confidence intervals(CIs).A random-effects model was used in the data *** potential publication bias for the variables was evaluated using Egger’s ***:A total of 86 observational studies involving 13,773 participants and 15,416 eyes were *** revealed that compared to healthy controls,the total macular thickness of AGM patients was thinner,including the thickness of fovea(-0.24,95%CI[-0.39,-0.08];P=0.002,I^(2)=87.7%),all regions of parafovea(-0.32,95%CI[-0.54,-0.11];P=0.003;I^(2)=71.7%)and the four quadrants of perifovea;the thickness of peripapillary retinal nerve fiber layer(pRNFL),macular retinal nerve fiber layer(mRNFL),and ganglion cell layer(GCL)also *** indicated that the superficial and deep vascular density decreased,the foveal avascular zone(FAZ)area enlarged,and the acircularity index(AI)reduced in AGM ***:Retinal thinning and microvascular lesions have occurred before the advent of clinically detectable DR;OCT and OCTA may have the potential to detect these preclinical ***:PROSPERO;http://***/prospero/;***42021269885.

关键词： Abnormal glucose metabolism optical coherence tomography optical coherence tomography angiography Diabetic retinopathy Prediabetes Meta-analysis

Aflibercept combined with triamcinolone acetonide in the treatment of diabetic macular edema:optical coherence tomography and optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 670-675页

作者： De-Shuang Li Hong-Xia Liao Chuan-He Zhang Jian-Guo Huang Wei Chen Jing-Lin Zhang Bo Qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Department of Ophthalmology the University of Hong Kong-Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To analyze the relationship between optical coherence tomography(OCT)and OCT angiography(OCTA)imaging in patients with diabetic macular edema(DME)who are treated with a combination of aflibercept and triamcinolone acetonide(TA).METHODS:A total of 76 eyes newly diagnosed DME were included in this *** were randomly assigned to receive either aflibercept or a combination of aflibercept and *** once a month for a total of three *** macular thickness(CMT),number of hyperreflective foci(HRF),height of subretinal fluid(SRF),and area of foveal avascular zone(FAZ)were evaluated using OCT and OCTA at baseline and after each monthly ***:Both groups showed improvement in best corrected visual acuity(BCVA)and reduction in macular edema after treatment,and the difference in BCVA between the two groups was statistically significant after each treatment(P<0.05).The difference in CMT between the two groups was statistically significant after the first two injections(P<0.01),but not after the third injection(P=0.875).The number of HRF(1mo:7.41±8.25 vs 10.86±7.22,P=0.027;2mo:5.33±6.13 vs 9.12±8.61,P=0.034;3mo:3.58±3.00 vs 6.37±5.97,P=0.007)and height of SRF(1mo:82.39±39.12 vs 105.77±42.26μm,P=0.011;2mo:36.84±10.02 vs 83.59±37.78μm,P<0.01;3mo:11.57±3.29 vs 45.43±12.60μm,P<0.01)in combined group were statistically significant less than aflibercept group after each injection,while the area of FAZ showed no significant change before and after treatment in both ***:The combination therapy of aflibercept and TA shows more significant effects on DME eyes with decreased HRF and ***,both aflibercept and combination therapy show no significant change in the area of FAZ.

关键词： diabetic macular edema optical coherence tomography optical coherence tomography angiography hyperreflective foci subretinal fluid foveal avascular zone aflibercept

Automatic fovea detection and choroid segmentation for choroidal thickness assessment in optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1763-1771页

作者： Chen Yu Lin Hung Ju Chen Yi Kit Chan Wei Ping Hsia Yu Len Huang Chia Jen Chang Department of Ophthalmology Taichung Veterans General HospitalTaichung 407TaiwanChina Department of Computer Science Tunghai UniversityTaichung 407TaiwanChina

AIM:To develop an automated model for subfoveal choroidal thickness(SFCT)detection in optical coherence tomography(OCT)images,addressing manual fovea location and choroidal contour ***:Two procedures were proposed:defining the fovea and segmenting the *** localization from B-scan OCT image sequence with three-dimensional reconstruction(LocBscan-3D)predicted fovea location using central foveal depression features,and fovea localization from two-dimensional en-face OCT(LocEN-2D)used a mask region-based convolutional neural network(Mask R-CNN)model for optic disc detection,and determined the fovea location based on optic disc relative *** segmentation also employed Mask ***:For 53 eyes in 28 healthy subjects,LocBscan-3D’s mean difference between manual and predicted fovea locations was 170.0μm,LocEN-2D yielded 675.9μ***-2D performed better in non-high myopia group(P=0.02).SFCT measurements from Mask R-CNN aligned with manual ***:Our models accurately predict SFCT in OCT ***-3D excels in precise fovea localization even with high ***-2D shows high detection rates but lower accuracy especially in the high myopia *** both models offers a robust SFCT assessment approach,promising efficiency and accuracy for large-scale studies and clinical use.

关键词： subfoveal choroidal thickness optical coherence tomography automatic foveal detection automatic choroid segmentation

optical coherence tomography in detection of dysplasia and cancer of the gastrointestinal tract and bilio-pancreatic ductal system

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World Journal of Gastroenterology 2008年第42期14卷 6444-6452页

作者： Pier Alberto Testoni Benedetto Mangiavillano Division of Gastroenterology and Gastrointestinal Endoscopy Vita-Salute San Raffaele University Scientific Institute San Raffaele Hospital Milan 20132 Italy

optical coherence tomography(OCT) is an optical imaging modality that performs high-resolution,cross-sectional,subsurface tomographic imaging of the microstructure of *** physical principle of OCT is similar to that of B-mode ultrasound imaging,except that it uses infrared light waves rather than acoustic *** in vivo resolution is 10-25 times better(about 10 μm) than with high-frequency ultrasound imaging,but the depth of penetration is limited to 1-3 mm,depending upon tissue structure,depth of focus of the probe used,and pressure applied to the tissue *** the last decade,OCT technology has evolved from an experimental laboratory tool to a new diagnostic imaging modality with a wide spectrum of clinical applications in medical practice,including the gastrointestinal(GI) tract and pancreatic-biliary ductal *** imaging from the GI tract can be done in humans by using narrow-diameter,catheter-based probes that can be inserted through the accessory channel of either a conventional front-view endoscope,for investigating the epithelial structure of the GI tract,or a side-view endoscope,inside a standard transparent ERCP catheter,for investigating the pancreatico-biliary ductal *** and the esophago-gastric junction has been the most widely investigated organ so far;more recently,also duodenum,colon and pancreatico-biliary ductal system have been extensively *** imaging of the gastro-intestinal wall structure is characterized by a multiple-layer architecture that permits an accurate evaluation of the mucosa,lamina propria,muscularis mucosae,andpart of the *** technique may be,therefore,used to identify pre-neoplastic conditions of the GI tract,such as Barrett's epithelium and dysplasia,and evaluate the depth of penetration of early-stage neoplastic *** imaging of the pancreatic and biliary ductal system could improve the diagnostic accuracy for ductal epithelial changes and the differential diagnosis be

关键词： optical coherence tomography Barrett'sepithelium Dysplasia Adenocarcinoma Gastrointestinal tract Pancreatico-biliary ductal system

optical coherence tomography of the living human kidney

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Journal of Innovative optical Health Sciences 2014年第2期7卷 88-97页

作者： Peter M.Andrews Hsing-Wen Wang Jeremiah Wierwlle Wei Gong Jennifer Verbesey Matthew Cooper Yu Chen Department of Biochemistry Molecular.and Celular Biology Georgetown University MedicalCenter WashingtonDC20007USA Fischell Department of Bioengineering Uriversity of Maryland College ParkMD 20742USA Colege of Photonic and Electric Engineering Fujian Normal University FuzhouChina Medstar Georgetown Transplant Inste Georgetown University Medical Center WashingtonD C 20007USA

Acute tubular necrosis(ATN)induced by ischemia is the most common insult to donor kidneysdestined for *** results from sweling and subsequent damage to cells lining thelkidney *** this study,we demonstrate the capability of optical coherence tomography(OcT)to image the renal microst ructures of living human donor kidneys and potentially providea measure to det ermine the extent of A *** also found that Doppler-based OCT(i.e.,DOCT)reveals renal blood flow dynamics that is another major factor which could relate to post-transplant renal *** OCT/DoCT oberva tions were performed in a noninvasive,sterileand timely manner on intact human kidneys both prior to(er vivo)and following(in vivo)*** results indicate that this imaging model provides transplant surgeons withan objective visualization of the transplant lidneys prior and immediately post transplantation.

关键词： optical coherence tomography doppler optical coherence tomography acute tubularnecrosis kidney transplantation uriniferous tubules glomerulus renal blood flow

optical coherence tomography Features of Tuberculous Serpiginous-like Choroiditis and Serpiginous Choroiditis

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Biomedical and Environmental Sciences 2018年第5期31卷 327-334页

作者： wang xiao na you qi sheng zhao hui ying peng xiao yan Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key Lab Beijing Tongren Hospital Capital Medical University Beijing 100730 China

Objective To investigate optical coherence tomography（OCT） characteristics of tuberculous serpiginous-like choroiditis（Tb-SLC） and serpiginous choroiditis（SC） and to perform OCT to differentiate between these *** This retrospective,case-control study examined consecutively enrolled patients with active Tb-SLC or *** underwent comprehensive ocular examinations and imaging（OCT,color fundus photography,autofluorescence imaging,fluorescein angiography,and indocyanine green angiography）.Findings were examined and compared between eyes with SC and *** Nine patients with active Tb-SLC（14 eyes） and 8 with active SC（12 eyes） were *** following OCT findings were observed significantly more often in the Tb-SLC group than in the SC group： vitreal hyper-reflective spots [5 Tb-SLC eyes（36%）,no SC eyes：P = 0.02],intraretinal edema [11 Tb-SLC eyes（79%）,3 SC eyes（25%）：P = 0.01],sub-retinal pigment epithelium（RPE） drusenoid deposits [11 Tb-SLC eyes（79%）,2 SC eyes（17%）：P 〈 0.01],and choroidal granulomas [8 Tb-SLC eyes（57%）,2 SC eyes（17%）：P = 0.03].A hyporeflective,wedge-shaped band was observed more often in the SC group [5 Tb-SLC eyes（36%）,9 SC eyes（75%）：P = 0.045] than in the Tb-SLC *** incidence of other OCT signs did not differ between the groups and included outer nuclear layer hyper-reflection,outer retinal tabulation,and choriocapillaris point-like *** Vitreal hyper-reflective spots,intraretinal fluid,sub-RPE drusenoid deposits,and choroidal granulomas on OCT images may indicate ***,a hyporeflective,wedge-shaped band may indicate ***,OCT is likely helpful in differentiating between Tb-SLC and SC.

关键词： optical coherence tomography Choroiditis Serpiginous Tuberculosis

optical coherence tomography FOR BLADDER CANCER DIAGNOSIS:FROM ANIMAL STUDY TO CLINICAL DIAGNOSIS

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Journal of Innovative optical Health Sciences 2008年第1期1卷 125-140页

作者： ZHIJIA YUAN HUGANG REN WAYNE WALTZER JASON KIM JINGXUAN LIU KEMIAO JIA HUIKAI XIE YINGTIAN PAN Departments of Biomedical Engineering Stony Brook UniversityStony BrookNYUSA Departments of Biomedical Urology Stony Brook UniversityStony BrookNYUSA Departments of Biomedical Pathology Stony Brook University Stony BrookNYUSA The ECE Department University of FloridaGainesvilleFLUSA

This paper summarizes the recent technological development in our lab on cystoscopic optical coherence tomography(COCT)by integrating time-domain OCT(TDOCT)and spectral-domain OCT(SDOCT)with advanced MEMS-mirror technology for endoscopic laser scanning *** COCT catheter can be integrated into the instrument channel of a commercial 22Fr rigid cystoscopic sheath for in vivo imaging of human bladder under the cystosocopic visual guidance;the axial/transverse resolutions of the COCT catheter are roughly 9μm and 12μm,respectively,and 2D COCT imaging can be performed with over 110dB dynamic range at 4–8 *** examine the utility and potential limitations of OCT for bladder cancer diagnosis,systemic ex vivo rat bladder carcinogenesis studies were performed to follow various morphological changes induced by tumor growth and in vivo porcine study was performed to examine the feasibility of COCT for in vivo *** by promising results of the animal studies,preliminary clinical study was conducted on patients scheduled for operating-room cystoscopy for bladder ***-blind clinical results reveal that COCT can delineate detailed bladder architectures(e.g.,urothelium,lamina propria,muscularis)at high resolution and detect bladder cancers based on enhanced urothelial heterogeneity as a result of excessive growing nature of bladder *** diagnostic sensitivity and specificity can be enhanced to 92%and 85%,*** also suggest that due to reduced imaging depth of COCT in cancerous lesions,staging of bladder cancers may be limited to Ta or T1 for non-outgrowing cancerous lesions.

关键词： optical coherence tomography bladder cancer diagnosis microelectromechanical system