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Inflammatory and nutritional markers in colorectal cancer: Implications for prognosis and treatment

World Journal of Clinical Oncology 2024年第10期15卷 1264-1268页

作者： Mesut Tez Department of Surgery University of Health SciencesAnkara City HospitalAnkara 06800Türkiye

The prognosis of colorectal cancer(CRC)patients with peritoneal metastasis remains poor despite advancements in detection and *** inflammatory and nutritional markers have emerged as significant predictors of prognosis in CRC,potentially guiding treatment decisions and improving patient *** editorial explores the prognostic value of markers such as the neutrophil-to-lymphocyte ratio,hemoglobin,and serum albumin *** integrating these markers into prognostic models,clinicians can better stratify patients,personalize treatment strategies,and ultimately enhance clinical *** review highlights the importance of these markers in providing a comprehensive assessment of patient condition and underscores the need for further research to validate their clinical utility and uncover underlying mecha-nisms.

关键词： Colorectal cancer Peritoneal metastasis Neutrophil-to-lymphocyte ratio Hemoglobin Serum albumin Inflammatory markers nutritional markers Prognosis Preoperative markers Personalized treatment

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Yield of testing for micronutrient deficiencies associated with pancreatic exocrine insufficiency in a clinical setting: An observational study

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World Journal of Clinical Cases 2021年第36期9卷 11320-11329页

作者： Mustafa Jalal Jennifer Anne Campbell Solomon Tesfaye Ahmed Al-Mukhtar Andrew Derek Hopper Academic Department of Gastroenterology Sheffield Teaching HospitalsSheffield S102JFUnited Kingdom Department of Infection Immunology and Cardiovascular diseaseUniversity of SheffieldSheffield S102TNUnited Kingdom Academic Unit of Diabetes and Endocrinology Sheffield Teaching HospitalsSheffield S102JFUnited Kingdom Department of Surgery Sheffield Teaching HospitalsSheffield S102JFUnited Kingdom

BACKGROUND Pancreatic exocrine insufficiency(PEI)can be difficult to diagnose and causes maldigestion symptoms and *** has been a number of studies that have identified PEI associated micronutrient deficiencies(PEI-MD),however there is variation in both the frequency and type of PEI-MD reported,with the majority of studies including patients with PEI due to chronic pancreatitis(CP)or CP without *** is a paucity of information regarding the prevalence of PEIMD in patients with PEI without CP and the yield of testing for PEI-MD in a clinical setting in patients with suspected benign pancreatic *** To prospectively assess the yield and type of PEI–MD in patients with and without PEI secondary to benign pancreatic *** Patients investigated for maldigestion symptoms with Faecal Elastase-1(FEL-1)and suspected or proven benign pancreatic disease were prospectively *** the time of FEL-1 testing,serum samples were taken for micronutrients identified by previous studies as PEI-MD:prealbumin,retinol binding protein,copper,zinc,selenium,magnesium and later in the study lipid adjusted vitamin ***-1 was recorded,with a result<200μg/g considered diagnostic of *** underwent computed tomography(CT)imaging when there was a clinical suspicion of CP,a new diagnosis of PEI recurrent,pancreatic type pain(epigastric abdominal pain radiating to back with or without previous acute pancreatitis attacks)or weight *** After exclusions,112 patients were recruited that underwent testing for FEL-1 and *** was identified in 41/112(36.6%)patients and a pancreatic CT was performed in 82 *** a PEI-MD was identified in 21/112(18.8%)*** yield of PEI-MD was 17/41(41.5%)if PEI was present which was significantly higher than those without 4/71(5.6%)(P=0.0001).The yield of PEI–MD was significantly higher when PEI and CP were seen together 13/22(59.1%)compared to CP without PEI and PEI without CP(P<0.03).In

关键词： Pancreatic exocrine insufficiency Chronic pancreatitis Micronutrient Malnutrition Malabsorption nutritional markers

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