Yield of testing for micronutrient deficiencies associated with pancreatic exocrine insufficiency in a clinical setting: An observational study

作     者：Mustafa Jalal Jennifer Anne Campbell Solomon Tesfaye Ahmed Al-Mukhtar Andrew Derek Hopper 

作者机构：Academic Department of GastroenterologySheffield Teaching HospitalsSheffield S102JFUnited Kingdom Department of InfectionImmunology and Cardiovascular diseaseUniversity of SheffieldSheffield S102TNUnited Kingdom Academic Unit of Diabetes and EndocrinologySheffield Teaching HospitalsSheffield S102JFUnited Kingdom Department of SurgerySheffield Teaching HospitalsSheffield S102JFUnited Kingdom 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第36期

页      面：11320-11329页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Pancreatic exocrine insufficiency Chronic pancreatitis Micronutrient Malnutrition Malabsorption Nutritional markers 

摘      要：BACKGROUND Pancreatic exocrine insufficiency(PEI)can be difficult to diagnose and causes maldigestion symptoms and *** has been a number of studies that have identified PEI associated micronutrient deficiencies(PEI-MD),however there is variation in both the frequency and type of PEI-MD reported,with the majority of studies including patients with PEI due to chronic pancreatitis(CP)or CP without *** is a paucity of information regarding the prevalence of PEIMD in patients with PEI without CP and the yield of testing for PEI-MD in a clinical setting in patients with suspected benign pancreatic *** To prospectively assess the yield and type of PEI–MD in patients with and without PEI secondary to benign pancreatic *** Patients investigated for maldigestion symptoms with Faecal Elastase-1(FEL-1)and suspected or proven benign pancreatic disease were prospectively *** the time of FEL-1 testing,serum samples were taken for micronutrients identified by previous studies as PEI-MD:prealbumin,retinol binding protein,copper,zinc,selenium,magnesium and later in the study lipid adjusted vitamin ***-1 was recorded,with a result200μg/g considered diagnostic of *** underwent computed tomography(CT)imaging when there was a clinical suspicion of CP,a new diagnosis of PEI recurrent,pancreatic type pain(epigastric abdominal pain radiating to back with or without previous acute pancreatitis attacks)or weight *** After exclusions,112 patients were recruited that underwent testing for FEL-1 and *** was identified in 41/112(36.6%)patients and a pancreatic CT was performed in 82 *** a PEI-MD was identified in 21/112(18.8%)*** yield of PEI-MD was 17/41(41.5%)if PEI was present which was significantly higher than those without 4/71(5.6%)(P=0.0001).The yield of PEI–MD was significantly higher when PEI and CP were seen together 13/22(59.1%)compared to CP without PEI and PEI without CP(P0.03).In