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Xiaochaihutang attenuates liver fibrosis in rats through activation of nrf2 pathway

中国药理学与毒理学杂志 2017年第10期31卷 988-989页

作者： Jin LI Rui HU Shang-fu XU Yuan-yang LI Jie LIU Ying QIN Zhi XIAO Zunyi Medical University Research Center for Medicine & Biology Zunyi Medical University Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education

OBJECTIVE Oxidative sress is one of the key factor responsible for occurrence and development of hepatic fibrosis,a common consequence of chronic liver injury of multiple *** factor erythroid 2-related factor 2(nrf2)serves as a major regulator of a celular defense system against oxidative ***(XCHT),a compound of seven botanical extracts used for liver diseases traditionally in East ***,few studies have investigated its anti-hepatic fibrosis effects and pathophysiological mechanism of *** present study was designed to confirm the anti-hepatic fibrosis effects and explore its potential mechanism of action by investigating the intervention of nrf2 *** Liver fibrosis was induced by repeated injection of Carbon tetrachloride(CCl4) over a period of 9 *** from the 6 th week,the animals in treatment groups were given the appropriate dose of XCHT granules and *** parameters,histological changes of the liver and alpha-smooth muscle actin(α-SMA) were *** expressions of nrf2,Keap1,Nqo1,HO-1,Gclc and Gclm were assessed by RT-PCR and Western *** CCl4 caused a significant fibrosis damage in the rat liver and the liver functions and fibrosis degree were significantly improved by XCHT(5 g·kg^(-1) and 10 g·kg^(-1)).XCHT(5 g·kg^(-1) and 10 g·kg^(-1)) treatment significantly decreased the number of cells labeled with α-SMA ***,XCHT(5 g·kg^(-1) and 10 g·kg^(-1))significantly increase Nqo1,HO-1,Gclc and Gclm expressions in the *** T hese studies establish XCHT is a potentially useful therapeutic agent for treatment of hepatic fibrosis and it might be via regulation of nrf2 pathway in rats against oxidative stress,making further efforts to inhibiting the activated *** or up-regulation of nrf2 pathway may be an alternative treatment strategy for liver fibrosis.

关键词： Xiaochaihutang liver fibrosis nrf2 pathway

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nrf2 pathway Involvement in the Beneficial Skin Effects of Moderate Ionic Osmotic Stress—The Case of The Dead Sea Water

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Journal of Cosmetics, Dermatological Sciences and Applications 2022年第2期12卷 109-130页

作者： Dror Cohen Ze’evi Ma’or Meital Portugal Cohen Miriam Oron Ron Kohen The Myers Skin Research Laboratory Faculty of Medicine Institute for Drug Research School of Pharmacy Hebrew University of Jerusalem Jerusalem Israel The Skin Research Institute The Dead-Sea & Arava Science Center Masada Israel Fosun Jinmei (Shanghai) Cosmetics Co. Ltd. Shanghai China AHAVA Dead Sea Laboratories Lod Israel Miriam Oron Mingelgrin Consulting Jerusalem Israel

Objectives: Exposing skin to moderate ionic osmotic stress (MIOS) triggers several biochemical responses. The objective of this work is to reveal the mechanism triggered by MIOS on the skin surface. Furthermore, this work aims to study the involvement of the nrf2 (nuclear factor erythroid-2-related factor 2) pathway, activated by MIOS, and its beneficial effect in protecting skin against stress via the stimulation of phase II enzymes. Methods: HaCaT cells and human skin organ culture were exposed to Dead Sea Water (DSW) as MIOS inducers and the induction of internal ROS elevation, nrf2 translocation, mRNA gene expressions of the phase II enzymes, heme-oxygenase 1 (HO1), and Catalase (CAT) were determined. Results: Skin exposure to MIOS increases nrf2 translocation to the nucleus, leading to increased levels of ROS, HO1, and CAT. Furthermore, exposing skin to MIOS promotes protection against UVB-related risks. This is demonstrated by attenuation of the expression of biomarkers, related to UVB-induced damage, Caspase-3, IL-8, and IL-1β. Conclusions: Skin exposure to MIOS leads to the activation of nrf2 skin defense pathway and, therefore, could present beneficial advantages to human skin health, as demonstrated on human skin models. The beneficial effects of MIOS, induced by DSW are significantly superior to eq. NaCl brine, suggests that MIOS protection of skin against stress is partially related to specific mineral combinations.

关键词： nrf2 pathway Ionic Osmotic Stress Dead Sea Water Oxidative Stress Human Skin Model

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Effects of Boron on antioxidant activity and nrf2 pathway in ostrich chicks kidney

Effects of Boron on antioxidant activity and Nrf2 pathway in...

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中国畜牧兽医学会动物解剖及组织胚胎学分会第十九次学术研讨会

作者： Jing Wang Haseeb Khaliq Pengpeng Sun Keli Yang Ke Xiao Abdur Rahman Ansari Juming Zhong Kemei Peng College of Veterinary Medicine Huazhong Agricultural University

The nrf2 pathway is a most important way in antioxidant capacity,regulating the cell’s redox homeostasis control *** addition,nrf2 pathway also can inhibit cell *** present study,the actions of boron on ostrich chickens kidney,especially in antioxidant capacity,were *** eight ostrich chickens were randomly divided into six equal groups supplemented the boron in the water,which was in the form of boric acid,at the concentration of 0,40,80,160,320 and 640 mg/L,*** relative oxidative/antioxidant enzymes(T-AOC,MDA,GSH-Px) and cell apoptosis in ostrich chicks kidney tissue were *** expression of three important genes in this pathway(nrf2,HO-1 and GCLC) were measured by quantitative real-time PCR,and the localization of key regulator nrf2 was also analyzed by *** results were as following:compared with control group,(1)MDA content was decreased in the 40,80 mg/L groups and significantly decreased(P nrf2 positive cells were mainly distributed in renal tubular cells and rarely in renal ***,The addition of boron,especially at 40,80 mg/L concentration,could bring a significantly increased in the expression of nrf2,HO-1,and *** together,the study demonstrated that low levels of boron(40,80mg/L,especially 80 mg/L) inhibited the cell apoptosis and improved antioxidant system,thus may improve ostrich chicks kidney tissue development;however,high levels of boron(320,640mg/L,especially 640 mg/L) would promote cell apoptosis and reduced the antio

关键词： ostrich chicks boron kidney tissue antioxidant capacity nrf2 pathway

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大鼠脊髓nrf2/HO-1通路参与不同部位电针调节神经性疼痛效应的机制探讨

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World Journal of Acupuncture-Moxibustion 2024年第2期34卷 130-137页

作者：陈柳潘昊天张衙楠多兰董馨王功命周嘉王珂上海中医药大学岳阳中西医结合医院针麻临床研究室上海200083 上海中医药大学针灸推拿学院上海201203

Objective:This study aimed to assess the effects of electroacupuncture(EA)at the contralateral,ipsilateral,or bilateral"Zusanli(ST36)"and"Yanglingquan(GB34)"on neuropathic pain caused by chronic contractile injury(CCI)and to explore the role of the nuclear factor erythroid 2-related factor 2(nrf2)pathway in the effects of ***:Male Sprague-Dawley rats were subjected to the CCI model to induce neuropathic pain.A total of 45 rats were randomly divided into five groups(n=9):sham,CCI,EA-Co(CCI+EA at contralateral acupoints),EA-Ip(CCI+EA at ipsilateral acupoints),and EA-Bi(CCI+EA at bilateral acupoints).The rats received EA treatment on day 8 after CCI,once every alternate day,for a total of eight *** time courses of mechanical pain threshold(MWT),hind paw withdrawal latency(HWL),and sciatic functional index(SFI)were *** expression levels of 8-hydroxydeoxyguanosine(8-OHdG),glutathione(GSH),superoxide dismutase(SOD)activity,interleukin-6(IL-6),interleukin-1 beta(IL-1β),and tumor necrosis factor factor-alpha(TNF-α)in the spinal cord were *** distribution of nrf2,its expression of nrf2 in both the cytosol and nucleus,and the protein levels of its downstream target genes,NQO1 and HO-1,were detected via double immunofluorescence staining and western blotting,***:Following CCI,both MWT and HWL in the CCI group significantly decreased from day 14 after surgery(P<0.001).EA treatment exhibited significant antinociceptive effects induced by CCI by increasing the MWT and HWL values,especially bilateral EA(P<0.05).The SFI of the CCI group was significantly lower than that of the sham group(P<0.001).Only bilateral EA improved the SFI scores compared to the CCI group(P<0.05).8-OHdG levels in the spinal cord of the CCI group were significantly higher than those in the sham group(P<0.05),whereas GSH levels and SOD activity in the spinal cord of the CCI group were significantly lower than those in the sham group(P<0.001 and P<0.01,respecti

关键词： Electroacupuncture Neuropathic pain nrf2 pathway Spinal cord

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Dracomolphesin A-E,five 3,4-seco-phenylpropanoids with nrf2 inducing activity from Dracocephalum moldavica

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Chinese Chemical Letters 2020年第5期31卷 1259-1262页

作者： Huaran Zhang Lintao Xu Xiaoqing Liu Jiangjiang Fan Xiaoning Wang Tao Shen Shuqi Wang Dongmei Ren Department of Natural Product Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJi'nan 250012China Department of Thoracic Surgery Qilu Hospital of Shandong UniversityJi'nan 250012China

Dracomolphesin A-E(1-5),five 3,4-seco-phenylpropanoids featuring an aromatic ring opened framework,were isolated from the aerial parts of Dracocephalum *** structures with absolute configurations were determined by spectroscopic methods coupled with Mosher ***,these compounds represented an example of aromatic ring cleavage products of *** possible biosynthetic pathway of these compounds was *** 1,2,4 and 5 were demonstrated to be nrf2 pathway activators.

关键词： 3,4-seco-phenylpropanoids Dracocephalum moldavica nrf2 pathway Dioxygenase Antioxidant

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Obacunone activates the nrf2-dependent antioxidant responses

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Protein & Cell 2016年第9期7卷 684-688页

作者： Xu, Shengmei Chen, Weimin Xie, Qingfeng Xu, Yang Guangzhou Univ Chinese Med Affiliated Hosp 2 Guangdong Prov Acad Chinese Med Sci Ctr Regenerat & Translat Med Guangzhou 510632 Guangdong Peoples R China Univ Calif San Diego Div Biol Sci 9500 Gilman Dr La Jolla CA 92093 USA

Dear Editor,The transcription factor nuclear factor erythroid 2-related factor 2 （nrf2） plays a crucial role in human antioxidant defense response against environmental insults. Small molecular chemical activators of nrf2 can confer protection against oxidative insults and inhibit the progression of diseases related to oxidative stress. Here, we identified oba- cunone as a novel activator of nrf2 by decreasing nrf2 ubiquitination and increasing its stability. In support of these findings, the systemic administration of obacunone strongly inhibits bleomycin-induced lung fibrosis in mice. Therefore,

关键词： Sulforaphane Tanshinone nrf2 Activator Environmental Insult nrf2 pathway

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