Dracomolphesin A-E,five 3,4-seco-phenylpropanoids with Nrf2 inducing activity from Dracocephalum moldavica

作     者：Huaran Zhang Lintao Xu Xiaoqing Liu Jiangjiang Fan Xiaoning Wang Tao Shen Shuqi Wang Dongmei Ren Huaran Zhang;Lintao Xu;Xiaoqing Liu;Jiangjiang Fan;Xiaoning Wang;Tao Shen;Shuqi Wang;Dongmei Ren

作者机构：Department of Natural Product ChemistryKey Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJi'nan 250012China Department of Thoracic SurgeryQilu Hospital of Shandong UniversityJi'nan 250012China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2020年第31卷第5期

页      面：1259-1262页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81973202) the Key Research and Development Program of Shandong Province (No. 2018GSF118085) 

主　　题：3,4-seco-phenylpropanoids Dracocephalum moldavica Nrf2 pathway Dioxygenase Antioxidant 

摘      要：Dracomolphesin A-E(1-5),five 3,4-seco-phenylpropanoids featuring an aromatic ring opened framework,were isolated from the aerial parts of Dracocephalum *** structures with absolute configurations were determined by spectroscopic methods coupled with Mosher ***,these compounds represented an example of aromatic ring cleavage products of *** possible biosynthetic pathway of these compounds was *** 1,2,4 and 5 were demonstrated to be Nrf2 pathway activators.