检索结果-南通市图书馆

Analyzing nootropic Effect of Phyllanthus reticulatus Poir. on Cognitive Functions, Brain Antioxidant Enzymes and Acetylcholinesterase Activity against Aluminium-Induced Alzheimer’s Model in Rats: Applicable for Controlling the Risk Factors of Alzheimer’s Disease

引用

Advances in Alzheimer's Disease 2016年第3期5卷 87-102页

作者： Md. Sahab Uddin Abdullah Al Mamun Mohammed Ashraful Iqbal Ariful Islam Md. Farhad Hossain Sayema Khanum Mamunur Rashid Department of Pharmacy Southeast University Dhaka Bangladesh Department of Chemistry Fareast International University Dhaka Bangladesh Department of Pharmacy State University of Bangladesh Dhaka Bangladesh Department of Pharmacy University of Rajshahi Rajshahi Bangladesh

Oxidative stress is intensely linked with neurodegenerative disorders, especially Alzheimer’s disease (AD). Searching for medicinal plant with the nootropic activity for controling the development and progression of AD has received extensive consideration. The plant Phyllanthus reticulatus (PR) Poir. is known in Bengali as Panjuli belongs to family Euphorbiaceae. Previous studies have shown the antioxidant, analgesic, anti-inflammatory, etc. activities of this plant. Therefore, the objective of this study was to examine the nootropic effect of ethanolic extracts of Phyllanthus reticulatus (EEPR) on cognitive functions, brain antioxidatant enzymes and acetylcholinesterase activity in aluminium-induced rats of cognitive impairment and oxidative stress. The effects of EEPR fruit (i.e., 100 and 200 mg/kg b.w.) were examined for 30 days and its nootropic effect was determined in aluminium treated Swiss albino male rats by behavioral studies such as Passive Avoidance (PA) test, Rewarded Alternation (RA) test and biochemical studies such as superoxide dismutase (SOD), catalase (CAT), contents of thiobarbituric acid reactive substances (TBARS) and acetylcholinesterase (AChE) activity in rats brain tissue homogenates. In PA test, administration of EEPR fruit (i.e., 100 and 200 mg/kg, b.w.) significantly (P < 0.05, P < 0.01) increased step-through latency (STL) in rats on 30th day with respect to disease control group. The percentage of memory retention (MR) for this test was pointedly (P < 0.05) increased in rats treated with EEPR fruit (i.e., 200 mg/kg b.w.) as compared with disease control group. For RA test, EEPR fruit (i.e., 200 mg/kg b.w.) markedly (P < 0.01) increased the correct responses (CR) in rats on 30th day related to disease control group. In case of this test the percentage of MR was significantly (P < 0.05, P < 0.01) increased in rats treated with EEPR fruit (i.e., 100 and 200 mg/kg b.w.) with respect to disease control group. Administration of EEPR fruit (i.

关键词： nootropic Phyllanthus reticulatus Cognitive Functions Brain Antioxidant Enzymes Acetylcholinesterase Activity Alzheimer’s Disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuropsychopharmacological profile of Astragalus membranaceous ***

引用

Journal of Traditional Chinese Medical Sciences 2019年第3期6卷 254-262页

作者： Aldarmaa Jalsrai Avijit Biswas Nikolai I.Suslov Joseph V.Martin Institute of Traditional Medicine and Technology 495 Ulaanbaatar-36Mongolia Biology Department Rutgers University315 Penn St.CamdenNJ 08102USA Research Institute of Pharmacology and Regenerative Medicine 3 Lenin Ave.Tomsk 634028Russia Center for Computational and Integrative Biology Rutgers UniversityCamdenNJ 08102USA

Objective:To clarify the neuropharmacological profile of the Mongolian vetch,Astragalus mongholicus(Astragalus membranaceous ***;synonym:***),extracts were evaluated for behavioral effects in rats and ***:An aqueous extract of *** was made by boiling roots from freshlycollected plants in 2.5 volumes(w/v)of water for 60 *** ethanol extract was made by incubating in 70%ethanol for 5 days at 25*** of the aqueous extracts were evaluated in a forced swimming assessment of antidepressant effects,a hole-board test of exploratory behavior,an analysis of inhibition of aggression following electrical stimulation and influences on amnesia resulting from ***,effects of ethanol extracts of *** were assessed on L-tryptophan induced twitches(indicating serotonin-mediated effects)and on hypothermia induced by apomorphine(indicating dopamine-mediated interactions)in ***:Per os(PO)administration of the aqueous decoction of the vetch to rats increased the response in a forced swimming test as reflected in wheel ***,the decoction had no significant effect on the exploratory behavior of rats in the hole-board *** PO administration of the aqueous extract of *** decreased the threshold for aggressive behavior and this effect persisted with subchronic *** administration of the plant extract suppressed aggression of *** ethanol extract of *** showed an antiserotoninergic action and had a significant influence on the hypothermia induced by ***:*** has a variety of potent psychotropic actions,suggesting influences on diverse neurotransmitter systems.

关键词： Antidepressant Anxiolytic Mongolian vetch nootropic Psychotropic effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：