Neuropsychopharmacological profile of Astragalus membranaceous ***

作     者：Aldarmaa Jalsrai Avijit Biswas Nikolai I.Suslov Joseph V.Martin 

作者机构：Institute of Traditional Medicine and Technology495 Ulaanbaatar-36Mongolia Biology DepartmentRutgers University315 Penn St.CamdenNJ 08102USA Research Institute of Pharmacology and Regenerative Medicine3 Lenin Ave.Tomsk 634028Russia Center for Computational and Integrative BiologyRutgers UniversityCamdenNJ 08102USA 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2019年第6卷第3期

页      面：254-262页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：The project was funded by the Mongolian Foundation of Science and Technology of Mongolia(17AT05IN324 AJ).Parts of the work were supported by the National Science Foundation(IOS-0724962(JVM)and DBI-0421079(JVM)) 

主　　题：Antidepressant Anxiolytic Mongolian vetch Nootropic Psychotropic effect 

摘      要：Objective:To clarify the neuropharmacological profile of the Mongolian vetch,Astragalus mongholicus(Astragalus membranaceous ***;synonym:***),extracts were evaluated for behavioral effects in rats and ***:An aqueous extract of *** was made by boiling roots from freshlycollected plants in 2.5 volumes(w/v)of water for 60 *** ethanol extract was made by incubating in 70%ethanol for 5 days at 25
*** of the aqueous extracts were evaluated in a forced swimming assessment of antidepressant effects,a hole-board test of exploratory behavior,an analysis of inhibition of aggression following electrical stimulation and influences on amnesia resulting from ***,effects of ethanol extracts of *** were assessed on L-tryptophan induced twitches(indicating serotonin-mediated effects)and on hypothermia induced by apomorphine(indicating dopamine-mediated interactions)in ***:Per os(PO)administration of the aqueous decoction of the vetch to rats increased the response in a forced swimming test as reflected in wheel ***,the decoction had no significant effect on the exploratory behavior of rats in the hole-board *** PO administration of the aqueous extract of *** decreased the threshold for aggressive behavior and this effect persisted with subchronic *** administration of the plant extract suppressed aggression of *** ethanol extract of *** showed an antiserotoninergic action and had a significant influence on the hypothermia induced by ***:*** has a variety of potent psychotropic actions,suggesting influences on diverse neurotransmitter systems.