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Physiotherapy for patients with depression:Recent research progress

World Journal of Psychiatry 2024年第5期14卷 635-643页

作者： Hui-Ling Liu Jing Sun Shi-Feng Meng Ning Sun Department of Mental Health First Clinical Medical College of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Rehabilitation First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina Department of Mental Health First Hospital of Shanxi Medical UniversityTaiyuan 030000Shanxi ProvinceChina

Depression,a common mental illness,seriously affects the health of individuals and has deleterious effects on society.The prevention and treatment of depression has drawn the attention of many researchers and has become an important social issue.The treatment strategies for depression include drugs,psychotherapy,and physiotherapy.Drug therapy is ineffective in some patients and psychotherapy has treatment limitations.As a reliable adjuvant therapy,physiotherapy compensates for the shortcomings of drug and psychotherapy and effectively reduces the disease recurrence rate.Physiotherapy is more scientific and rigorous,its methods are diverse,and to a certain extent,provides more choices for the treatment of depression.Physiotherapy can relieve symptoms in many ways,such as by improving the levels of neurobiochemical molecules,inhibiting the inflammatory response,regulating the neuroendocrine system,and increasing neuroplasticity.Physiotherapy has biological effects similar to those of antidepressants and may produce a superimposed impact when combined with other treatments.This article summarizes the findings on the use of physiotherapy to treat patients with depression over the past five years.It also discusses several methods of physiotherapy for treating depression from the aspects of clinical effect,mechanism of action,and disadvantages,thereby serving as a reference for the in-depth development of physiotherapy research.

关键词： Depression Physiotherapy non-pharmacological Rehabilitation therapy Recent advances

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non-pharmacological intervention for posterior cortical atrophy

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World Journal of Clinical Cases 2016年第8期4卷 195-201页

作者： Agnès Weill--Chounlamountry Jorge Alves Pascale Pradat--Diehl Département de Médecine Physique et de Réadaptation AP-HP H?pitaux Pitié-Salpêtrière Charles Foix GRC-UPMC Handicap Cognitif et Réadaptation Center for Evidence-Based Neuro Rehabilitation CEREBRO-Brain Health Center Laboratoire d’Imagerie Biomédicale (LIB) Inserm U1146 Sorbonne Universités UPMC UMCR2-CNRS UMR7371

Posterior cortical atrophy(PCA) is a rare neurodegene-rative condition characterized by progressive visual-perceptual deficits. Although the neurocognitive profile of PCA is a growing and relatively well-established field, non-pharmacological care remains understudied and to be widely established in clinical practice. In the present work we review the available literature on non-pharmacological approaches for PCA, such as cognitive rehabilitation including individual cognitive exercises and compensatory techniques to improve autonomy in daily life, and psycho-education aiming to inform people with PCA about the nature of their visual deficits and limits of cognitive rehabilitation. The reviewed studies represented a total of 7 patients. There is a scarcity of the number of studies, and mostly consisting of case studies. Results suggest non-pharmacological intervention to be a potentially beneficial approach for the partial compensation of deficits, improvement of daily functionality and improvement of quality of life. Clinical implications and future directions are also highlighted for the advancement of the field, in order to clarify the possible role of non-pharmacological interventions, and its extent, in PCA.

关键词： Cognitive rehabilitation Posterior cortical atrophy Alzheimer’s disease non-pharmacological intervention Neuropsychological rehabilitation

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non-pharmacological cognitive intervention for aging and dementia:Current perspectives

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World Journal of Clinical Cases 2013年第8期1卷 233-241页

作者： Jorge Alves Rosana Magalh?es álvaro Machado óscar F Gon?alves Adriana Sampaio Agavni Petrosyan Neuropsychophysiology Lab CIPsiSchool of PsychologyUniversity of Minho4710-057BragaPortugal Department of Neurology Hospital de Braga4710-243 BragaPortugal Department of Counseling and Applied Educational Psychology Bouvé College of Health SciencesNortheastern UniversityBostonMA 02115United States Department of Cognitive Sciences University of California at IrvineIrvineCA 92717United States

In recent years, cognitive difficulties associated with normal aging and dementia have been receiving increased attention from both public and scientific communities. With an increase in overall lifespan, promoting healthy cognition has become a priority and a necessity for minimizing and preventing individual and societal burdens associated with cognitive dysfunctions in the elderly. The general awareness concerning the efficacy of preventive(e.g., lifestyles) and palliative treatment strategies of cognitive impairments, related to either healthy or unhealthy trajectories in cognitive aging, is continuously rising. There are several therapeutic strategies which can be broadly classified as either pharmacological or non-pharmacological/psychosocial. In face of the modest evidence for success of pharmacological treatments, especially for dementia related impairments, psychosocial interventions are progressively considered as a complementary treatment. Despite the relative spread of psychosocial interventions in clinical settings, research in this area is rather scarce with evidence for success of these therapies remaining controversial. In this work we provide an evidence based perspective on cognitive intervention(s) for healthy aging, pre-dementia(mild cognitive impairment), and dementia populations. Current evidence and future directions for improving cognitive functions in the elderly are discussed as well.

关键词： Dementia Aging Cognitive intervention Cognition non-pharmacological therapies

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Efficacy of non-pharmacological interventions in controlling type 2 diabetes in patients of African descent: A systematic review

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Journal of Biomedical Science and Engineering 2013年第5期6卷 36-44页

作者： Takira Glasgow Liz Cheek Naji Tabet Computing Engineering and Mathematics University of Brighton Brighton UK Postgraduate Medicine Division of Medical Education Brighton and Sussex Medical School Brighton UK

Purpose: The purpose of this review is to systematically assess the potential effectiveness of targeted educational and other non-pharmacological interventions on diabetes control in populations of African descent in developed countries. Such information can inform intervention strategies and highlight evidence-based approaches to deal with this significant problem in this population. Methods: A systematic review and a meta-analysis of random controlled trials and cohort studies evaluating the influence of education and other non-pharmacological interventions on HbA1Cconcentrations in patients of African descent with diabetes. A comprehensive search of PubMed, EMBASE, CINAHL, ZETOC, SIGLE databases was carried out. Results: Although nine studies (8 randomised controlled trials and 1 cohort study) met the inclusion criteria, relevant HbA1Cdata were available for 6 of the studies for the subsequent meta-analysis. Heterogeneity of meta-analysis was high (I2 = 92%), the random effects pooled standard mean difference favoured the intervention -0.66 (-1.15, -0.17), p = 0.009. After sensitivity analysis, I2 remained moderate to high at 69%. The random effects pooled standard mean difference continued to favour the intervention -0.48 (-0.81, -0.16), p = 0.009. Conclusion: There is evidence supporting the efficacy of educational and other non-pharmacological interventions in diabetes control in populations of African descent in English speaking developed countries. This conclusion is tempered by the significant heterogeneity of selected interventions and paucity of high quality research in the target population.

关键词： Diabetes Education African Descent non-pharmacological Intervention HbA1C

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Lights at night:does photobiomodulation improve sleep?

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Neural Regeneration Research 2023年第3期18卷 474-477页

作者： Audrey Valverde Catherine Hamilton Cécile Moro Malvina Billeres Pierre Magistretti John Mitrofanis UniversitéGrenoble Alpes FDD and CEA-LETIClinatecGrenobleFrance WellRed Inc LauncestonTasmaniaAustralia King Abdullah University of Science and Technology Thuwal Saudi Arabia Institute of Ophthalmology University College LondonLondonUK

Sleep is a critical part of our daily routine.It impacts every organ and system of our body,from the brain to the heart and from cellular metabolism to immune function.A consistent daily schedule of quality of sleep makes a world of difference to our health and well-being.Despite its importance,so many individuals have trouble sleeping well.Poor quality sleep has such a detrimental impact on many aspects of our lives;it affects our thinking,learning,memory,and movements.Further,and most poignantly,poor quality sleep over time increases the risk of developing a serious medical condition,including neurodegenerative disease.In this review,we focus on a potentially new non-pharmacological treatment that improves the quality of sleep.This treatment,called photobiomodulation,involves the application of very specific wavelengths of light to body tissues.In animal models,these wavelengths,when applied at night,have been reported to stimulate the removal of fluid and toxic waste-products from the brain;that is,they improve the brain’s inbuilt house-keeping function.We suggest that transcranial nocturnal photobiomodulation,by improving brain function at night,will help improve the health and well-being of many individuals,by enhancing the quality of their sleep.

关键词： aquaporin 4 glymphhatic infrared non-pharmacological red sleep cap transcranial wakefulness

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Lights for epilepsy:can photobiomodulation reduce seizures and offer neuroprotection?

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Neural Regeneration Research 2023年第7期18卷 1423-1426页

作者： Napoleon Torres-Martinez Stephan Chabardes John Mitrofanis University of Grenoble Alpes FDD and CEA-LETIClinatecGrenobleFrance

Epilepsy is synonymous with individuals suffering repeated“fits”or seizures.The seizures are triggered by bursts of abnormal neuronal activity,across either the cerebral cortex and/or the hippocampus.In addition,the seizure sites are characterized by considerable neuronal death.Although the factors that generate this abnormal activity and death are not entirely clear,recent evidence indicates that mitochondrial dysfunction plays a central role.Current treatment options include drug therapy,which aims to suppress the abnormal neuronal activity,or surgical intervention,which involves the removal of the brain region generating the seizure activity.However,~30%of patients are unresponsive to the drugs,while the surgery option is invasive and has a morbidity risk.Hence,there is a need for the development of an effective non-pharmacological and non-invasive treatment for this disorder,one that has few side effects.In this review,we consider the effectiveness of a potential new treatment for epilepsy,known as photobiomodulation,the use of red to near-infrared light on body tissues.Recent studies in animal models have shown that photobiomodulation reduces seizure-like activity and improves neuronal survival.Further,it has an excellent safety record,with little or no evidence of side effects,and it is non-invasive.Taken all together,this treatment appears to be an ideal treatment option for patients suffering from epilepsy,which is certainly worthy of further consideration.

关键词： cell death gliosis inflammation infrared mitochondria non-pharmacological red seizure

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Exercise training in the management of patients with resistant hypertension

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World Journal of Cardiology 2015年第2期7卷 47-51页

作者： Fernando Ribeiro Rui Costa José Mesquita-Bastos School of Health Sciences University of Aveiro Portugal and CINTESIS.UA 3810-193 Aveiro Portugal School of Health Sciences University of Aveiro3810-193 Aveiro Portuga

Hypertension is a very prevalent risk factor for cardiovascular disease. The prevalence of resistant hypertension, i.e., uncontrolled hypertension with 3 or more antihypertensive agents including 1 diuretic, is between 5% and 30% in the hypertensive population. The causes of resistant hypertension are multifactorial and include behavioral and biological factors, such as nonadherence to pharmacological treatment. All current treatment guidelines highlight the positive role of physical exercise as a non-pharmacological tool in the treatment of hypertension. This paper draws attention to the possible role of physical exercise as an adjunct non-pharmacological tool in the management of resistant hypertension. A few studies have investigated it, employing different methodologies, and taken together they have shown promising results. In summary, the available evidence suggests that aerobic physical exercise could be a valuable addition to the optimal pharmacological treatment of patients with resistant hypertension.

关键词： Exercise training Resistant hypertension Blood pressure non-pharmacological Cardiovascular disease

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Treating Comorbid Insomnia in Older Adults via Cognitive-Behavioural Treatment, Bright Light and Exercise

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Health 2014年第10期6卷 960-968页

作者： K. Richter J. Myllymaeki S. Scharold-Schaefer I. Tomova R. Mayrer G. Niklewski Clinic for Psychiatry and Psychotherapy Nuremberg Hospital Nuremberg Germany Psychotherapeutical Practice Weissenburg Germany Sozialstiftung Bamberg Clinic for Psychiatry Psychosomatic and Psychotherapy Clinic Bamberg Bamberg Germany

Background: Insomnia occurs frequently in older adults. The underlying factors for the disorder are physiological changes of the sleep-wake cycle, comorbid diseases and drug treatment. Cognitive behavioural therapy (CBT I) combined with light therapy and physical activity can be effective in the treatment of comorbid insomnia in older adults. Methods: Sixty-three (63) insomnia patients (47 female, 16 male) with an average age of 66.6 years participated in the program. Before and after the treatment, the participants completed questionnaires to assess their sleep quality (PSQI), day-time sleepiness (ESS), mood (BDI) and well-being (WHO-5-Index). In addition, they kept sleep diaries for six weeks. Results: Pre-post comparisons revealed a significant improvement in sleep latency and sleep quality, as well as a significant reduction of day-time sleepiness. In patients with both insomnia and depression, all depression scores improved slightly but significantly. Conclusions: non-pharmacological combination treatment using CBT I, light therapy and physical activity seemed to be effective in older adults with comorbid insomnia and improve additionaly depressive symptoms.

关键词： Insomnia non-pharmacological Treatment Older Adults CBT Light Therapy Physical Activity

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Male osteoporosis: A review

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World Journal of Orthopedics 2012年第12期3卷 223-234页

作者： Antonio Herrera Antonio Lobo-Escolar Jesús Mateo Jorge Gil Elena Ibarz Luis Gracia Department of Orthopedic and Trauma Surgery Miguel Servet University Hospital 50009 Zaragoza Spain Department of Mechanical Engineering University of Zaragoza 50009 Zaragoza Spain

Osteoporosis in men is a heterogeneous disease that has received little attention.However,one third of worldwide hip fractures occur in the male population.This problem is more prevalent in people over70 years of age.The etiology can be idiopathic or secondary to hypogonadism,vitamin D deficiency and inadequate calcium intake,hormonal treatments for prostate cancer,use of toxic and every disease or drug use that alters bone metabolism.Risk factors such as a previous history of fragility fracture should be assessed for the diagnosis.However,risk factors in men are very heterogeneous.There are significant differences in the pharmacological treatment of osteoporosis between men and women fundamentally due to the level of evidence in published trials supporting each treatment.New treatments will offer new therapeutic prospects.The goal of this work is a revision of the present status knowledge about male osteoporosis.

关键词： Male osteoporosis Skeleton involution Etiology Fracture risk Osteoporosis non-pharmacological treatments pharmacological treatments

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在类型 2 糖尿病的生活方式干预的机械学的研究

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World Journal of Diabetes 2012年第12期3卷 201-207页

作者： Analava Mitra Debasis Dewanjee Baishakhi Dey School of Medical Science and Technology IIT Kharagpur 721302India

AIM:To investigate the effect of lifestyle interventions in the non-pharmacological management of type 2 diabetes via a mechanistic approach.METHODS:A randomized controlled trial was carried out on 60 type 2 diabetic male and female volunteers that fulfilled the inclusion criteria,with their proper consent and permission of the International Electrotechnical Commission for 1 year.30 patients were included in the test group and 30 patients in the control group.Demographic details,anthropometrical status,physical activity,food habits and blood glucose lipid profile of the volunteers were recorded at baseline,the test group was directed for lifestyle intervention and final blood glucose lipid data were collected at the end of one year of patient follow-up.RESULTS:After 1 year,the test group who had a lifestyle intervention was found to show a significant improvement in blood glucose lipid profile.The fasting plasma glucose level(FPG),postprandial plasma glucose level(PPG),glycosylated hemoglobin(HbA1c) and body mass index(BMI) values of the test group were reduced significantly,up to 145 ± 2.52,174 ± 2.59,6.3 ± 0.32 and 25 ± 0.41 respectively at the end of the study period,in comparison to the control group whereFPG,PPG,HbA1c and BMI values were 193 ± 3.36,249 ± 4.24,7.2 ± 0.42 and 26 ± 0.65 respectively.Improvement in the total cholesterol(TC),triglyceride(TG),high-density lipoproteins(HDL) and low-density lipoproteins(LDL) values of the test group was also remarkable in comparison to the control group.The TC,TG,HDL and LDL values of the test group were reduced significantly,up to 149 ± 3.32,124 ± 2.16,58 ± 0.62 and 118 ± 2.31,respectively.CONCLUSION:The significant improvement in the blood glucose lipid profile of the test group after 1 year signifies the value of non-pharmacological management of type 2 diabetes via lifestyle intervention strategies.

关键词： Metabolic Unconventional Therapeutic Interventions non-pharmacological Sedentary Lifestyle Counseling

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