Lights for epilepsy:can photobiomodulation reduce seizures and offer neuroprotection?

作     者：Napoleon Torres-Martinez Stephan Chabardes John Mitrofanis Napoleon Torres-Martinez;Stephan Chabardes;John Mitrofanis

作者机构：University of Grenoble AlpesFDD and CEA-LETIClinatecGrenobleFrance 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第7期

页      面：1423-1426页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：Fonds de Dotation (FDD) Clinatec COVEA France 

主　　题：cell death gliosis inflammation infrared mitochondria non-pharmacological red seizure 

摘      要：Epilepsy is synonymous with individuals suffering repeated“fitsor *** seizures are triggered by bursts of abnormal neuronal activity,across either the cerebral cortex and/or the *** addition,the seizure sites are characterized by considerable neuronal *** the factors that generate this abnormal activity and death are not entirely clear,recent evidence indicates that mitochondrial dysfunction plays a central *** treatment options include drug therapy,which aims to suppress the abnormal neuronal activity,or surgical intervention,which involves the removal of the brain region generating the seizure ***,~30%of patients are unresponsive to the drugs,while the surgery option is invasive and has a morbidity ***,there is a need for the development of an effective non-pharmacological and non-invasive treatment for this disorder,one that has few side *** this review,we consider the effectiveness of a potential new treatment for epilepsy,known as photobiomodulation,the use of red to near-infrared light on body *** studies in animal models have shown that photobiomodulation reduces seizure-like activity and improves neuronal ***,it has an excellent safety record,with little or no evidence of side effects,and it is *** all together,this treatment appears to be an ideal treatment option for patients suffering from epilepsy,which is certainly worthy of further consideration.