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a Clinical Observation of Stellate Ganglion Block Used for Migraine

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中国组织工程研究 2001年第9期15卷 156-158页

作者：张淑珍高淑琴王恩真 Department of Anesthesiology Beijing Tiantan HospitalAffiliate of Capital University of Medical Sciences

To observe the therapeutic effect of different drugs used in stellate ganglion block (SGB) on migraine, 80 patients suffering from migraine were randomly allocated into two groups. In group A STB were treated with mixture of lidocaine, vitamine B complex and txiamcinolone acetonide, while in group B nimodipine was also added. The analgestic duration and effect were measured by double－blinded. The analgestic duration in groupB was significantly longer than in group A and the complete pain－relieving percentage was significantly high (P<0.05) in group B.

关键词： migraine stellate ganglion block nimodipine

尼莫地平(nimodipine)治疗突发性聋临床观察

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北京医学 1990年第5期12卷 302-302页

作者：冯彦廉能静蔡正华刘鋋北京市耳鼻咽喉科研究所

突发性聋(Sudden deafness)是病因学不明的突然发生的感音神经性聋,多表现为单侧耳聋、耳鸣及耳堵塞感,约半数患者可伴有眩晕、恶心、呕吐等症状。多数学者认为本病可能与病毒感染、血循环障碍及迷路窗膜破裂有关。关于治疗方面,除窗膜... 详细信息

突发性聋(Sudden deafness)是病因学不明的突然发生的感音神经性聋,多表现为单侧耳聋、耳鸣及耳堵塞感,约半数患者可伴有眩晕、恶心、呕吐等症状。多数学者认为本病可能与病毒感染、血循环障碍及迷路窗膜破裂有关。关于治疗方面,除窗膜破裂需手术治疗外,一般主张改善内耳血液循环和局部代

关键词：治疗后突发性聋尼莫地平 nimodipine

新型钙拮抗剂nimodipine的质谱研究

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质谱学报 2001年第2期22卷 59-63页

作者：余志立胡来兴胡琼莹王占国杨细文曹廷富周凤珍中国医学科学院天津中央制药厂天津300400

本文报告了新型钙拮抗剂nimodipine的EIMS谱、HR -EIMS数据和1 3 CNMR(COM .INEPT)谱和数据。根据HREI数据讨论了主要特征碎片离子的可能裂解途径。其中许多碎片离子是由麦氏重排而得。

关键词：钙拮抗剂 nimodipine 裂解途径麦氏重排

Clinical Efficacy of Shenmai Injection in the Treatment of Cerebral Vasospasm after Ruptured Aneurysm Surgery

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Case Reports in Clinical Medicine 2021年第10期10卷 253-263页

作者： Tianya Wu Jingxin Fu Xinghuo Jin Qichao Chen Huanming Huang Shiqi Chen Junan Zhou Longbiao Xu Department of Neurosurgery Zhuji Affiliated Hospital of Shaoxing University Zhuji People’ Hospital of Zhejiang Province Zhuji China Department of Chinese Medicine Zhuji Yaojiang Town Central Health Center of Zhejiang Province Zhuji China The Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine Zhuji China

Objective: To investigate the therapeutic effect of Shenmai Injection on postoperative cerebral vasospasm in patients with ruptured aneurysms. Methods: Seventy patients undergoing craniotomy for ruptured aneurysms in our hospital were selected as study subjects and randomly divided into control (n = 33) and research (n = 37) groups, they were treated with nimodipine and nimodipine combined with Shenmai injection after operation. The blood flow velocity in the middle cerebral artery (MCA) before and at 1, 3, 7, 11 and 14 days after surgery and the incidence of cerebral vasospasm during these days were compared, and the GCS scores at 14 days postoperatively and GOS scores at 6 months postoperatively were compared between the two groups. Results: There were no statistically significant differences in the occurrence of cerebral vasospasm, GCS or GOS scores between the two groups (P > 0.05), but the period of postoperative cerebral vasospasm in the study group was significantly shorter than that in the control group. Conclusion: Shenmai injection has the effect of shortening the cycle of occurrence of cerebral vasospasm after the operation of ruptured aneurysms, promoting patients to recover as early as possible and reducing their physical and mental burden.

关键词： Shenmai Injection nimodipine Ruptured Aneurysm Aneurysmal Subarachnoid Hemorrhage Cerebral Vasospasm

Hemostatic Therapy for Intracerebral Hemorrhage

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Open Journal of Modern Neurosurgery 2017年第4期7卷 121-128页

作者： Xingxia Wang Jie Gong Ping Gu Zhibao Zhao Qingwen Jin Department of Neurology the First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Internal Medicine Yizheng People’s Hospital Yizheng China

Objective: To reduce the blood pressure and elevate intracranial pressure using nimodipine (Nimotop Intravenous (IV) infusion). Thus, intracerebral hemorrhage was controlled, and the purpose of hemostasis was achieved. Methods: Sixty-eight patients with intracerebral hemorrhage were divided into a treatment group (n = 51), and a control group (n = 35). Nimotop solution (10 mg) was administered as a fast-flowing IV infusion in the treatment group, and 250 ml 20% mannitol infusion was given to patients in the control group twice every day. Patients in both groups received treatment for seven days, and the blood pressure on the treatment day was measured. A brain Computed Tomography (CT) scan was performed as a reexamination within two weeks. Results: The blood pressure in the treatment group was decreased from 179/104 to 151/91 mmHg, averagely, and in the control group was decreased from 181/108 to 180/103 mmHg, averagely. The difference between these two groups was statistically significant (P nimodipine can dilate the arteries, reduce blood pressure, and elevate intracranial pressure, lowering pressure gradients across vessel wall which destroy the vessel wall. Also, nimodipine can prevent hemorrhage as well as recurrent hemorrhage, and can used as the first choice of rescue drug. What’s more, dehydration drugs such as mannitol should not be used in the early stage of intracerebral hemorrhage in order to prevent hematoma enlargement.

关键词： nimodipine Intracerebral Hemorrhage Hypertension Cranial Hypertension

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星形胶质细胞存在L-型钙通道的新证据

Zoological Research 2007年第5期28卷 485-490页

作者：王磊蔡景霞中国科学院昆明动物研究所脑与行为实验室

以纯化培养的小鼠星形胶质细胞(Astrocyte,AS)为实验材料,采用激光共聚焦钙成像和荧光分光光度计技术,探讨钙激动剂Bay k8644和钙拮抗剂nimodipine对星形胶质细胞胞内钙离子浓度的影响。结果显示,Bay k8644在0.0001、0.001和0.01mmol/L... 详细信息

以纯化培养的小鼠星形胶质细胞(Astrocyte,AS)为实验材料,采用激光共聚焦钙成像和荧光分光光度计技术,探讨钙激动剂Bay k8644和钙拮抗剂nimodipine对星形胶质细胞胞内钙离子浓度的影响。结果显示,Bay k8644在0.0001、0.001和0.01mmol/L浓度下均可显著增加星形胶质细胞的细胞内钙水平,而nimodipine在0.001、0.01和0.1mmol/L浓度下均可显著降低星形胶质细胞胞内钙水平,并阻止KCl引起的细胞内钙升高。上述结果表明星形胶质细胞对L-型钙通道激动剂和拮抗剂的反应与神经元的反应相似,提示星形胶质细胞胞膜上也存在L-型钙通道。

关键词：星形胶质细胞细胞内钙浓度 nimodipine Bay k8544 L-型钙通道

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钠通道Na(v)1.6与缺血性脑损伤

中风与神经疾病杂志 2013年第6期30卷 493-496页

作者：任丽王玉凯黄铭娜龙赤黄海鹰佛山市禅城区中心医院神经内科广东佛山528031 佛山市第一人民医院神经内科广东佛山528000

目的通过观察大鼠缺血脑组织中Na(v)1.6表达探讨Na(v)1.6与缺血性脑损伤的关系。方法线栓法制作大鼠脑缺血模型,168只SD大鼠分为假手术组、脑缺血组和钠通道阻滞剂-riluzole、钙通道阻滞剂-ni-modipine治疗组。大鼠脑缺血后6h、1d、2d... 详细信息

目的通过观察大鼠缺血脑组织中Na(v)1.6表达探讨Na(v)1.6与缺血性脑损伤的关系。方法线栓法制作大鼠脑缺血模型,168只SD大鼠分为假手术组、脑缺血组和钠通道阻滞剂-riluzole、钙通道阻滞剂-ni-modipine治疗组。大鼠脑缺血后6h、1d、2d、3d取材,应用免疫组化检测Na(v)1.6表达,荧光法检测钙离子浓度,氯化三苯四唑染色检测脑梗死体积。结果 Na(v)1.6在脑缺血后6h～1d表达上调,2～3d表达下调;相同时间点nimodipine治疗组与缺血组相比较,Na(v)1.6表达变化不明显;riluzol治疗组Na(v)1.6表达变化明显,差异具有显著性(Pnimodipine治疗组钙离子浓度、脑梗死体积均比缺血组降低,riluzol治疗组降低最明显,差异具有显著性(P<0.05)。结论钠离子内流发生在脑缺血的早期阶段;脑缺血后Na(v)1.6表达上调,抑制Na(v)1.6表达可以减轻脑缺血损伤,Na(v)1.6参与了缺血性脑损伤。

关键词：脑缺血 Riluzole nimodipine 大鼠 Na(v)1 6

The　changes　of　neuronal　Ca^（2＋）　channel　and　its　effects　on　BBB　permeability　and　cerebral　edema　associated　with　brain　injury

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Journal of Medical Colleges of PLA(China) 1994年第1期9卷 9-12页

作者：徐如祥易声禹

ＴｈｅｃｈａｎｇｅｓｏｆｎｅｕｒｏｎａｌＣａ^（２＋）ｃｈａｎｎｅｌａｎｄｉｔｓｅｆｆｅｃｔｓｏｎＢＢＢｐｅｒｍｅａｂｉｌｉｔｙａｎｄｃｅｒｅｂｒａｌｅｄｅｍａ　ａｓｓｏｃｉａｔｅｄｗｉｔｈｂｒａｉｎｉｎｊｕｒｙＸｕ... 详细信息

ＴｈｅｃｈａｎｇｅｓｏｆｎｅｕｒｏｎａｌＣａ^（２＋）ｃｈａｎｎｅｌａｎｄｉｔｓｅｆｆｅｃｔｓｏｎＢＢＢｐｅｒｍｅａｂｉｌｉｔｙａｎｄｃｅｒｅｂｒａｌｅｄｅｍａ　ａｓｓｏｃｉａｔｅｄｗｉｔｈｂｒａｉｎｉｎｊｕｒｙＸｕＲｕｘｉａｎｇ（徐如祥）；ＹｉＳｈ?..

关键词： brain injuries cerebral edema ion channels calcium channe kers blood-brain barrier nimodipine rats

Application of HATR-FTIR Spectroscopy to the Analysis of Nifedipine Tablets

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Application of HATR-FTIR Spectroscopy to the Analysis of Nif...