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nicotinamide mononucleotide supplementation improves the quality of porcine oocytes under heat stress

Journal of Animal Science and Biotechnology 2022年第5期13卷 1326-1339页

作者： Meijie Song Yu Li Yihang Zhou Jiner Yan Xiaohua Zhou Qian Gao Yilong Miao Bo Xiong College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China College of Veterinary Medicine Nanjing Agricultural UniversityNanjing 210095China

Background:Elevated ambient temperature-caused heat stress is a major concern for livestock production due to its negative impact on animal feed intake,growth,reproduction,and ***,the germ cells are extremely sensitive to the heat ***,the effective approach and strategy regarding how to protect mammalian oocytes from heat stress-induced defects have not been ***:Germinal vesicle(GV)porcine oocytes were cultured at 41.5℃ for 24 h to induce heat stress,and then cultured at 38.5℃ to the specific developmental stage for subsequent *** mononucleotide(NMN)was dissolved in water to 1 mol/L for a stock solution and further diluted with the maturation medium to the final concentrations of 10μmol/L,20μmol/L,50μmol/L or 100μmol/L,respectively,during heat *** and fluorescence intensity quantification were applied to assess the effects of heat stress and NMN supplementation on the key processes during the oocyte meiotic ***:Here,we report that NMN supplementation improves the quality of porcine oocytes under heat ***,we found that heat stress resulted in oocyte maturation failure by disturbing the dynamics of meiotic organelles,including the cytoskeleton assembly,cortical granule distribution and mitochondrial *** addition,heat stress induced the production of excessive reactive oxygen species(ROS)and DNA damage,leading to the occurrence of apoptosis in oocytes and subsequent embryonic development *** importantly,we validated that supplementation of NMN during heat stress restored the meiotic defects during porcine oocyte ***:Taken together,our study documents that NMN supplementation is an effective approach to improve the quality of oocytes under heat stress by promoting both nuclear and cytoplasmic maturation.

关键词： Heat stress Meiotic defects nicotinamide mononucleotide Oocyte quality Porcine oocytes

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Research Progress on the Application of β-nicotinamide mononucleotides in Cosmetics

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China Detergent & Cosmetics 2023年第2期8卷 73-80页

作者： Liu Lu Bai Liqiang Li Yang Hangzhou DaddyLab Technology Co. Ltd.China

Recent studies have found that nicotinamide mononucleotide(nicotinamide mononucleotide,NMN)also has certain anti-aging,photoprotection,anti-oxidation,and soothing to the skin,while affects the level of nicotinamide adenine dinucleotide(nicotinamide adenine dinucleotide,NAD+)to improve aging-related *** skincare features have laid the foundation for its application in *** has been used in cosmetics and sold on the market in foreign countries,but there have been debates about its *** is currently as a new raw material for cosmetics in China,and its safety is also under *** paper systematically reviewed the basic properties,skin care functions and the safety of its application in cosmetics,aiming to provide theoretical reference for the development and application of NMN.

关键词： nicotinamide mononucleotide NMN cosmetics anti-aging photoprotection anti-oxidation soothing safety

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