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Diagnostic and prognostic significance of the lymphocyte/C-reactive protein ratio,neutrophil/lymphocyte ratio,and D-dimer values in patients with COVID-19

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BIOCELL 2022年第12期46卷 2625-2635页

作者： ALPASLAN OZTURK MEHMET KARA Department of Medical Biochemistry Amasya University Faculty of MedicineAmasya05000Turkey Department of Infectious Diseases and Clinical Microbiology Beylikduzu State HospitalIstanbul34000Turkey

In this study,our aim was to examine the diagnostic and prognostic significance of lymphocyte/C-reactiveprotein ratio(LCR),neutrophil/lymphocyte ratio(NLR)and D-dimer parameters in COVID-19 *** LCR,NLR,neutrophil count,mean platelet volume(MPV),C-reactive protein(CRP),and D-dimer parameters wereevaluated *** was a retrospective cohort study with 1000 COVID-19 positive and 1000 healthycontrol groups,all over the age of 18 *** ratio(OR)and 95%confidence interval(CI)values were calculatedfor each parameter found to be statistically significant in the univariate and multivariate logistic regression ***,127(12.7%)of the COVID-19^(+)patients,whose data was included in this study,*** neutrophil,MPV,CRP,D-dimer,and NLR values were higher in the COVID-19^(+)/deceased group than in the COVID-19^(+)/alive andcontrol groups(plymphocyte and LCR values were lower inthe COVID-19^(+)/deceased group than in the COVID-19^(+)/alive and control groups(plymphocyte,LCR,D-dimer,NLR,CRP,MPV,PLT,and neutrophil *** significant variables in predicting mortality due to COVID-19 were LCR,CRP,NLR,lymphocyte,D-dimer,neutrophil,and MPV values.A low LCR and high NLR are associated with thepresence,prognosis,and mortality due to *** and NLR parameters can thus be used in clinicalmonitoring to reduce morbidity and mortality rates.

关键词： COVID-19 lymphocyte/C-reactive protein ratio neutrophil/lymphocyte ratio D-dimer Inflammation

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Association of neutrophil/lymphocyte ratio with long-term mortality after ST elevation myocardial infarction treated with primary percutaneous coronary intervention

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Chinese Medical Journal 2010年第23期123卷 3438-3443页

作者： SHEN Xu-hua CHEN Qi SHI yan LI Hong-wei Department of Cardiology Beijing Friendship Hospital Affiliatedto Capital Medical University Beijing 100050 China Department of Computer Capital Medical University Beijing100030 China

Background Primary percutaneous coronary interventions （PCI） have been proposed as a novel superior management strategy in patients with ST elevation myocardial infarction （STEMI）. This study tested the hypothesis that in the acute phase of myocardial infarction with ST-segment elevation, the neutrophil/lymphocyte （N/L） ratio is a predictor of long-term *** We analyzed 551 consecutive STEMI patients treated with primary PCl at a single university center. Patients were stratified according to quartiles of the mean neutrophil/lymphocyte *** Kaplan-Meier survival analysis showed a cumulative eight-year survival of 94.2% in the first quartile, 92.0% in the second quartile, 91.3% in the third quartile, and 75.4% in the fourth quartile （P ＜0.001 by log rank）. Relative to patients in the other three lower N/L ratio quartiles, patients in the highest quartile were more than four times more likely to die during hospitalization （P ＜0.001） and during long-term follow-up （P ＜0.001）. By multivariate Cox regression analysis including baseline demographic, clinical, and angiographic covariables, the N/L ratio in the highest quartile remained an independent predictor of mortality （hazard ratio 2.38, 95% confidence interval （CI） 1.42 to 3.98; P=0.001）.Conclusion The neutrophil/lymphocyte ratio is a strong independent predictor of long-term mortality after ST elevation myocardial infarction treated with very early revascularization.

关键词： neutrophil/lymphocyte ratio primary percutaneous coronary intervention ST elevation myocardial infarction inflammation

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Value of neutrophil/lymphocyte ratio,N-terminal pro-B-type natriuretic peptide,urea,and creatinine for the prediction of acute kidney injury in acute heart failure:a retrospective observational study

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Journal of Bio-X Research 2021年第4期4卷 171-178页

作者： Lisi Huang Jian He Xianghua Lin Ling Luo Rihui Zhong Xiaoying Xie Xiaodan Peng Chaohui Duan Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Department of Clinical Laboratory Sun Yat-sen Memorial HospitalSun Yat-sen University State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong ProvinceChina

Objective:Early identification of acute kidney injury(AKI)is essential to improve the prognosis of patients with acute heart failure(AHF).We aimed to determine the utility of neutrophil/lymphocyte ratio(NLR),N-terminal prohormone of brain natriuretic peptide(NT-proBNP),urea,and creatinine(Cr),as well as combinations of these,for the prediction of AKI in patients with ***:A total of 153 patients with AHF under the care of Sun Yat-sen Memorial Hospital,Sun Yat-sen University from October 2009 to October 2019 were included in this retrospective observational *** NLR,NT-proBNP,urea,and Cr concentrations were measured on *** was defined using the Acute Kidney Injury Network *** operating characteristic(ROC)curves,the areas under the curves(AUCs),sensitivity,and specificity were employed to evaluate the ability of each biomarker and their combinations to identify *** study was approved by the Ethics Committee of Sun Yat-sen Memorial Hospital,Sun Yat-sen University(approval ***-KY-KS-2021-126)on June 22,***:Forty-six(30.1%)participants developed AKI during *** NLR and NT-proBNP of the participants with AKI were higher than those without(NLR:median 7.886 vs 4.717,P<0.0001;NT-proBNP,median 6774 vs 2786pg/mL,P<0.0001).ROC analyses demonstrated that high NLR and NT-proBNP were associated with higher incidences of AKI(NLR:cut-off 5.681,AUC 0.716,sensitivity 58.9%,specificity 80.4%;NT-proBNP:cut-off 5320pg/mL,AUC 0.700,sensitivity 72.9%,specificity 65.2%).Moreover,a combination of NLR,NT-proBNP,urea,and Cr yielded an AUC of 0.815,sensitivity 80.4%,and specificity of 74.8%.In addition,the AUCs for the prediction of AKI in the participants with New York Heart Association(NYHA)classes II,III,and IV were 0.936,0.860,and 0.772,respectively,using this ***:A combination of NLR,NT-proBNP,urea,and Cr,measured at admission,may represent a promising tool for the prediction of AKI in patients with

关键词： acute kidney injury creatinine neutrophil/lymphocyte ratio N-terminal pro-B-type natriuretic peptide urea

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C-reactive protein is differentially modulated by co-existing infections,vitamin deficiencies and maternal factors in pregnant and lactating indigenous Panamanian women

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Infectious Diseases of Poverty 2017年第1期6卷 819-832页

作者： Doris Gonzalez-Fernandez Emerita del Carmen Pons Delfina Rueda Odalis Teresa Sinisterra Enrique Murillo Marilyn E.Scott Kristine G.Koski School of Dietetics and Human Nutrition Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3V9Canada Department of Nutritional Health Ministry of HealthAnconPanama CityPanama “Comarca Ngabe-Bugle”Health Region Ministry of HealthSan FelixChiriqui ProvincePanama “Panama Norte”Health Region Ministry of HealthLas Cumbres SquareTransithmian HighwayPanama CityPanama Department of Biochemistry University of PanamaSimon Bolivar Avenue(Transithmian Highway)Panama CityPanama Department of Biochemistry University of PanamaManuel Espinoza Batista and Jose De Fabrega AvenuesPanama CityPanama Institute of Parasitology and Centre for Host-Parasite Interactions Macdonald Campus of McGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada School of Dietetics and Human Nutrition and Centre for Host-Parasite Interactions Macdonald CampusMcGill University21111 Lakeshore RoadSte-Anne-de-BellevueQC H9X 3 V9Canada

Background:The usefulness of C-reactive protein(CRP)as a non-specific marker of inflammation during pregnancy and lactation is unclear in impoverished populations where co-existing infections and vitamin deficiencies are ***:This cross-sectional study in Panama recruited 120 pregnant and 99 lactating Ngäbe-Buglewomen from 14 communities in rural *** history,indoor wood smoke exposure,fieldwork,BMI,vitamins A,B_(12),D,and folic acid,and inflammation markers(CRP,neutrophil/lymphocyte ratio(NLR),plateletcrit and cytokines)were *** regressions explored both associations of CRP with other inflammatory markers and associations of CRP and elevated CRP based on trimester-specific cut-offs with maternal factors,infections and vitamin ***:CRP was higher in pregnancy(51.4±4.7 nmol/L)than lactation(27.8±3.5 nmol/L)and was elevated above trimester specific cut-offs in 21%of pregnant and 30%of lactating *** deficiencies were common(vitamin A 29.6%;vitamin D 68.5%;vitamin B1268%;folic acid 25.5%)and over 50%of women had two or more concurrent deficiencies as well as multiple *** regression models highlighted differences in variables associated with CRP between pregnancy and *** pregnancy,CRP was positively associated with greater indoor wood smoke exposure,caries and hookworm and negatively associated with Ascaris and vaginal Lactobacillus and Bacteroides/Gardnerella *** with this,greater wood smoke exposure,caries as well as higher diplococcal infection score increased the odds of trimester-elevated CRP concentrations whereas longer gestational age lowered the likelihood of a trimester-elevated *** lactation,folic acid deficiency was associated with higher CRP whereas parity,number of eosinophils and Mobiluncus score were associated with lower ***,a higher BMI and Trichomonas vaginalis score increased the likelihood of an elevated CRP whereas higher parity and numbe

关键词： CRP Intestinal parasites Caries Vaginal infections Folic acid deficiency Wood smoke neutrophil/lymphocyte ratio Plateletcrit Pregnancy Lactation

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Value of Preoperative Hematological Parameters in the Prognosis of Gastric Cancer Patients Undergoing a Total Gastrectomy

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Current Medical Science 2022年第2期42卷 348-356页

作者： Xi-shan ZHU Ye ZHAO Fei-yan MA Shi-kai WU Oncology Department Peking University First HospitalBeijing100034China Pathology Department Peking University First HospitalBeijing100034China

Objective This study aimed to evaluate the relationships between the albumin/globulin ratio(AGR),neutrophil/lymphocyte ratio(NLR),and platelet/lymphocyte ratio(PLR)and clinicopathological information for gastric cancer *** addition,the prognostic values of these hematological parameters for resectable gastric cancer patients undergoing a total gastrectomy were *** A total of 245 patients with gastric cancer who underwent a total gastrectomy at our hospital between January 1,2005,and December 30,2015,were enrolled into this *** preoperative AGR,NLR,and PLR in the serum samples of the patients were *** relationships between the hematological parameters and the disease-free survival(DFS)as well as overall survival(OS)were analyzed by statistical *** The cutoff values of AGR,NLR,and PLR were 1.57,3.5,and 193,*** analyses demonstrated that a low AGR,a high NLR,and a high PLR were significant risk factors for a poor *** to multivariate analysis,a high PLR was found to be independently associated with a poor ***,when age was considered as a stratified factor,univariate analyses demonstrated that a low AGR had the tendency to be correlated with a shorter DFS in nonelderly patients(<65 years old).A low AGR was significantly correlated with a shorter DFS and OS in elderly patients(≥65 years old).Conclusion AGR,NLR,and PLR are independent risk factors associated with a poor gastric cancer survival by univariate analysis,and AGR is an independent risk factor for predicting DFS and OS in elderly patients(≥65 years old)with gastric cancer after total gastrectomy.

关键词： albumin/globulin ratio neutrophil/lymphocyte ratio platelet/lymphocyte ratio gastric cancer prognosis disease-free survival overall survival cancer microenvironment gastrectomy

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Association between routine hematological parameters and sudden sensorineural hearing loss:A meta-analysis

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Journal of Otology 2021年第1期16卷 47-54页

作者： Wei Ni Shao-Peng Song Yi-Dao Jiang Department of Otolaryngology-Head and Neck Surgery Jingzhou Central HospitalThe Second Clinical Medical CollegeYangtze UniversityJing Zhou434020PR China

Objective:Recent studies have shown that chronic inflammation contributes to the development of sudden sensorineural hearing loss(SSNHL).Some hematologic parameters have also been linked to the prognosis of ***,the prognostic value of such hematological factors is not *** study explored the association of routine hematological parameters with ***:A systematic literature search was conducted in PubMed,Cochrane Library,Web of Science and Embase to identify eligible *** mean deviation(SMD)and the 95%confidence interval(CI)were retried from relevant studies for ***,subgroup,and publication bias analyses were ***:A total of 18 studies involving 1505 SSNHL patients and 1466 healthy persons were enrolled in the final *** study population included 699 responders and 458 non-responders to *** results revealed that the neutrophil/lymphocyte ratio(NLR)and platelet/lymphocyte ratio(PLR)value in the SSNHL patient group were higher than in the healthy group(SMD=1.05,95%CI:0.86,1.24,p<0.001,SMD=0.52,95%CI:0.26,0.78,p<0.001,respectively).However,there was no significant difference in the mean platelet volumes(MPV)between the groups(SMD=0.03,95%CI:0.44,0.49,p=0.91).Notably,NLR and PLR values were evidently higher in the unrecovered group than in the recovered group(SMD=0.63,95%CI:1.02,0.23,p=0.002,SMD=0.4,95%CI:0.76,0.03,p=0.03,respectively).However,the MPV value was similar in both groups(SMD=0.35,95%CI:1.14,0.44,p=0.38).Conclusions:Our results show that NLR and PLR values can predict the onset and prognosis of SSNHL.

关键词： Sudden sensorineural hearing loss Prognosis neutrophil/lymphocyte ratio Platelet/lymphocyte ratio Meta-analysis

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