Value of Preoperative Hematological Parameters in the Prognosis of Gastric Cancer Patients Undergoing a Total Gastrectomy

作     者：Xi-shan ZHU Ye ZHAO Fei-yan MA Shi-kai WU Xi-shan ZHU;Ye ZHAO;Fei-yan MA;Shi-kai WU

作者机构：Oncology DepartmentPeking University First HospitalBeijing100034China Pathology DepartmentPeking University First HospitalBeijing100034China 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2022年第42卷第2期

页      面：348-356页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by the Science Foundation of Peking University First Hospital 

主　　题：albumin/globulin ratio neutrophil/lymphocyte ratio platelet/lymphocyte ratio gastric cancer prognosis disease-free survival overall survival cancer microenvironment gastrectomy 

摘      要：Objective This study aimed to evaluate the relationships between the albumin/globulin ratio(AGR),neutrophil/lymphocyte ratio(NLR),and platelet/lymphocyte ratio(PLR)and clinicopathological information for gastric cancer *** addition,the prognostic values of these hematological parameters for resectable gastric cancer patients undergoing a total gastrectomy were *** A total of 245 patients with gastric cancer who underwent a total gastrectomy at our hospital between January 1,2005,and December 30,2015,were enrolled into this *** preoperative AGR,NLR,and PLR in the serum samples of the patients were *** relationships between the hematological parameters and the disease-free survival(DFS)as well as overall survival(OS)were analyzed by statistical *** The cutoff values of AGR,NLR,and PLR were 1.57,3.5,and 193,*** analyses demonstrated that a low AGR,a high NLR,and a high PLR were significant risk factors for a poor *** to multivariate analysis,a high PLR was found to be independently associated with a poor ***,when age was considered as a stratified factor,univariate analyses demonstrated that a low AGR had the tendency to be correlated with a shorter DFS in nonelderly patients(65 years old).A low AGR was significantly correlated with a shorter DFS and OS in elderly patients(≥65 years old).Conclusion AGR,NLR,and PLR are independent risk factors associated with a poor gastric cancer survival by univariate analysis,and AGR is an independent risk factor for predicting DFS and OS in elderly patients(≥65 years old)with gastric cancer after total gastrectomy.