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neuropsychological features in post-stroke cognitive impairment with no dementia patients with different Traditional Chinese Medicine syndromes

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Journal of Traditional Chinese Medicine 2019年第1期39卷 97-102页

作者： Ma Jie Wang Yu Zhang Yunyun Guo Qihao Zhen Xiaomin Shi Moyi Department of Neurology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Department of Gerontology Shanghai Jiaotong University Affiliated Sixth People's HospitalShanghai 200233China Internal Medicine of Traditional Chinese Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

OBJECTIVE: To investigate neuropsychological features of post-stroke cognitive impairment with no dementia(PSCIND) patients with different Traditional Chinese Medicine(TCM) ***: We recruited 50 patients with PSCIND between April 2012 and March 2013. Patients were divided into different groups according to TCM classifications. Patients were assessed using neuropsychological tests, including cognitive screening(mini-mental state examination), memory testing (auditory verbal learning test), executive/attention[shape trails test, stroop color-word test(SCWT),reading the mind in the eyes test, the digit ordering test-A(DOT-A), and symbol digit modalities test], language(action naming test, Boston naming test, famous face test, similarity test, and verbal fluency test), and visuospatial functioning [complex figure test(CFT)].RESULTS: We found no significant differences between patients with and without a diagnosis of turbid phlegm blocking the upper orifices on neuropsychological test performance. Patients diagnosed with upper hyperactivity of liver Yang syndrome scored significantly lower on the SCWT-C executive test and the CFT-delayed recall memory test. Patients with excess syndrome scored significantly lower on the SCWT-C executive test, and significantly higher on the DOT-A executive ***: neuropsychological characteristics differ between PSCIND patients with different TCM classifications.

关键词： Cognitive dysfunction Stroke Syndromes and signs neuropsychological tests

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Association between Pre-pregnancy Body Mass Index and Offspring neuropsychological Development from 1 to 24 Months of Age: A Birth Cohort Study in China

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Biomedical and Environmental Sciences 2019年第10期32卷 730-738页

作者： CAO Lu Jia LIN Hong Yan LIANG Xuan CHEN Yong Jie LIU Yu Yan ZHENG Yu Zhi WANG Xin Yan LI Wen YAN Jing HUANG Guo Wei Department of Nutrition and Food Science School of Public HealthTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China Department of Epidemiology and Statistics School of Public HealthTianjin Medical UniversityTianjin 300070China Department of Social Medicine and Health Administration School of Public HealthTianjin Medical UniversityTianjin 300070China

Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in *** In this birth cohort study, a total of 2,253 mother-child pairs were enrolled in Tianjin, China,between July 2015 and May 2018. The China Developmental Scale for Children was used to assess developmental quotient(DQ) of children aged from 1 to 24 *** Mixed-models analysis revealed significant age × pre-pregnancy BMI interactions for total DQ and five neurobehavioral domains(gross motor, fine motor, adaptive, language, and social;P neuropsychological development. It also revealed a short-term positive impact of high pre-pregnancy BMI on neuropsychological development at 1 month of age, but a long-term negative effect(from 1 to24 months).

关键词： Pre-pregnancy BMI neuropsychological development Offspring The first 1,000 days Birth cohort study

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neuropsychological and Electrophysiological Evaluation after Rape: A Case Study of a Teenage Girl

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Journal of Behavioral and Brain Science 2014年第6期4卷 256-267页

作者： Lucía Ester Rizo-Martínez Miguel ángel Guevara Luis Francisco Cerdán Francisco Abelardo Robles-Aguirre Araceli Sanz-Martin Marisela Hernández-González Centro Universitario del Norte Universidad de Guadalajara Colotlán México Instituto de Neurociencias CUCBA Universidad de Guadalajara Guadalajara Jalisco México

Although rape is an event with a high incidence worldwide, there is currently no single consensus about both the general effects and the diagnosis and treatment of this. To evaluate the consequences of rape, a teenage girl was evaluated at two moments: a month-and-a-half and then a year-and-a-half after being raped. Clinical measurements, neuropsychological testing and electroencephalographic recording (EEG) were conducted in four conditions: eyes closed, eyes open, and during performance of two tasks: Towers of Hanoi and Wisconsin. Observations showed subsyndromal symptoms of post-traumatic stress on the first evaluation, and close-to-normal scores on the neuropsychological and cognitive tests in both assessments. Decreased cortical EEG synchronization, mainly in the fast frequencies and in almost all conditions, was obtained in the second evaluation. The results obtained in this study may indicate an early development in the brain, which is discussed in light of current literature on this topic.

关键词： Rape Adolescence EEG Clinical Evaluation neuropsychological Testing

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neuropsychological and Neurological Deficits in Obsessive-Compulsive Disorder: The Role of Comorbid Depression

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International Journal of Clinical Medicine 2012年第3期3卷 200-210页

作者： Habibollah Ghassemzadeh Ramin Mojtabai Nargess Karamghadiri Maryam Noroozian Vandad Sharifi Nargess Ebrahimkhani Depart- ment of Mental Health Johns Hopkins Bloomberg School of Public Health Baltimore USA. Roozbeh Hospital Department of Psychiatry School of Medicine Tehran University of Medical Sciences Tehran Iran

Past research has found a high prevalence of neuropsychological deficits and neurological soft signs in patients with obsessive-compulsive disorder (OCD). A close relationship between OCD and depression has also been indicated in the literature. However, many aspects of this association remain unclear. In this study we compared neuropsychological functioning and neurological soft signs of 46 OCD patients who were off psychotropic medication (21 with significant depressive symptoms and 25 without) with 25 non-patient comparison subjects. The patients were matched to the comparison group with regard to age, sex, education, marital status and handedness. There were significant differences between OCD patients and the non-patient comparison group on neuropsychological functioning but not on neurological soft signs. As far as working memory concerns there was a significant difference between the OCD depressed and non-depressed groups. But we found no evidence that the neuropsychological functions such as cognitive flexibility, problem solving and spatial perception in OCD to be attributable to comorbid depression. The pattern of neuropsychological deficits in this sample of OCD patients is suggestive of orbito-frontal as well as dorsolateral prefrontal cortical dysfunction.

关键词： Obsessive Compulsive Disorder OCD Depression neuropsychological Assessment Neurological Assessment Soft Signs

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Absence of Quantitative Improvement in neuropsychological Profiles in Patients Who Exhibit Moderate Brain Impairment: Comparisons of Cross-Sectional and Longitudinal Data (1 through 4 Years Post-Injury)

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Journal of Behavioral and Brain Science 2013年第2期3卷 225-238页

作者： Sandra G. Tiller Linda S. St-Pierre Michael A. Persinger Clinical Neuropsychology Laboratory Department of Psychology and Behavioural Neuroscience Program Laurentian University Sudbury Canada

A total of 127 adult patients who had sustained an impact of significant mechanical energy to their skulls during motor vehicle incidents were given thorough neuropsychological, cognitive and personality assessments between 0.5 years and 4 years after the event. Cross-sectional analysis indicated no statistically significant objective changes in patients as a function of yearly intervals. However there was strong evidence of significant deterioration of neuropsychological proficiency and efficiency between 0.3 to 1.0 years after the injury. A subset (n = 20) of patients who displayed moderately severe neuropsychological impairment when assessed about 1 year after the injury showed no statistically significant changes when reassessed about 1.5 years later (2.5 years after the brain trauma). These results challenge the traditional concept of “recovery” following a traumatic brain injury and indicate that insidious processes that adversely affect neurocognitive capacity may emerge 0.5 years after the trauma. Post-hoc analysis indicated that the occurrence of unconsciousness or its duration at the time of the injury minimally affected the magnitude of subsequent indices of neuropsychological impairment but influenced the incidence of electroencephalographic theta activity during the years following the injury.

关键词： TBI neuropsychological Impairment Test-Retest Reliability Personality Electroencephalographic Indicators

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Mild Cognitive Impairment in Parkinson Disease: A neuropsychological Study of 25 Patients

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World Journal of Neuroscience 2018年第4期8卷 470-479页

作者： Siham Sanhaji Mounia Rahmani Maria Benabdeljlil Mustapha El Alaoui Faris Service of Neurology A and Neuropsychology Rabat Specialty Hospital Rabat Morocco

Parkinson’s disease (PD) is associated with an increased incidence of cognitive impairment and dementia. Population-based cohort of 25 patients with incident PD underwent a large neuropsychological battery. Executive functions were the most affected cognitive domain including particularly initiation, mental flexibility and inhibition. Episodic memory and visuo-spatial functions were less affected. We found that 92% of patients were classified as having Mild Cognitive Impairment (MCI);most of them experienced PD-MCI Single-Domain (17 patients) with disturbances on executive functions. Less frequently, we identified a group of patients with multiple-domain PD-MCI demonstrating deficits on executive functions as well as on episodic memory and/or visuospatial capacities.

关键词： MCI PD neuropsychological Study Executive Functions Episodic Memory Visuospatial Capacities

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Replace Psychometric Inferences with Direct Brain Measurements: LORETA Reflects Traditional Cerebral Loci for neuropsychological Tests

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Neuroscience & Medicine 2015年第3期6卷 107-115页

作者： Paula L. Corradini Michael A. Persinger Clinical Neuropsychology Laboratory Laurentian University Sudbury Canada Behavioural Neuroscience Program Laurentian University Sudbury Canada Department of Psychology Laurentian University Sudbury Canada Biomolecular Sciences Program Laurentian University Sudbury Canada

Inferences of subtle cerebral injury and dysfunction have been historically dependent upon psychometric tests from which clinical neuropsychological profiles are generated. In addition to being secondary, over-inclusive and crude indicators of cerebral activity, psychometric tests are subject to economic incentives to “re-norm” traditional methods under the pretense of “ensuring” contemporary representations that are sanctioned by regulating organizations dominated by agendas of control over the interpretations of clinicians. The validity of neuropsychological tests is essential for their perspicacious application and interpretations. We measured the quantitative electroen-cephalographic profiles and calculated s-LORETA (standardized Low Resolution Electromagnetic Tomography) profiles in real time for normal men and women while they engaged in both traditional and novel neuropsychological tests that were employed to infer localized brain injury. Conspicuous alterations in source current density within specific frequency bands occurred within various regions of the right prefrontal region during performance of the Category, Design Fluency and Conditioned Spatial Association Test, the prefrontal medial surface during Toe Graphaesthesia, the caudal medial surface during Toe Gnosis, the left temporal region during Speech-Sounds, and within the right retrosplenial-parahippocampal region for Seashore Rhythms. Results supported the well established regional associations with the classic neuropsychological tests, verified the cerebral localization with more recent procedures, and emphasized the utility of modern real-time, direct cerebral imaging procedures.

关键词： s-LORETA neuropsychological Tests Category Test Conditioned Spatial Association Test Design Fluency Test Seashore Rhythm Test Speech Sounds Rhythm Test

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A Survey on neuropsychological State, Oxidative Stress and Hematological Parameters in Coke Oven Workers

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Health 2014年第11期6卷 1230-1236页

作者： Behnaz Salehiforouz Ali Akbar Malekirad Mohammad Abdollahi Kobra Rahzani Sara Mostafalou Biology Department Payame Noor University Tehran Iran Faculty of Nursing and Midwifery Arak University of Medical Science Arak Iran Faculty of Pharmacy Pharmaceutical Sciences Research Center Tehran University of Medical Science Tehran Iran

Coke oven factories are one of the main emitting sources of polycyclic aromatic hydrocarbons (PAH)s which have been identified as highly carcinogenic chemicals by IARC. Induction of oxidative stress and following disrupting pathways has been repeatedly reported in subjects exposed to PAHs. This study was performed to monitor the oxidative stress markers, hematological and biochemical parameters, and psychological states in coke oven workers. 100 male subjects were included in this comparative cross-sectional study. At first 50 male workers who were 22 - 63 and worked in the steel factory located in South-East of Iran were contained. Control subjects were chosen from Esfahan, in the factory’s neighborhood, consisting of 50 office workers without any background of occupational exposure to metals. The blood levels of hematological factors and oxidative stress were measured. In order to compare data, two-sample t test was applied. In order to measure the correlation between variables, Pearson correlation coefficient was applied. The mean level of total antioxidant capacity, hemoglobin (Hb), mean corpuscular hemoglobin concentration (MCHC), and hematocrit were significantly lower in the workers in association with increased lipid per oxidation (LPO). A positive correlation existed between work history, hyper thyroids (r2 = 0.288, p = 0.01), and endocrine disorders (r2 = 0.309, p = 0.028). Occupational exposure of coke oven workers to PAHs can induce oxidative stress and consequent metabolic and neuropsychological disorders. When workers take daily shower and use protective tools, absorption of toxic elements would decrease so that reaching them to the body can be suitably limited.

关键词： Coke Oven Workers neuropsychological State Oxidative Stress Hematological Parameters

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Regional patterns of atrophy on MRI in Alzheimer’s disease: neuropsychological features and progression rates in the ADNI cohort

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Advances in Alzheimer's Disease 2013年第4期2卷 135-147页

作者： Ranjan Duara David A. Loewenstein Qian Shen Warren Barker Maria T. Greig Daniel Varon Melissa E. Murray Dennis W. Dickson Department of Neurology Miller School of Medicine University of Miami Miami USA Herbert Wertheim College of Medicine Florida International University Miami USA Mayo Clinic Jacksonville USA Wien Center for Alzheimer’s Disease and Memory Disorders Mount Sinai Medical Center Miami Beach USA

Background: Discrete clinical and pathological subtypes of Alzheimer’s disease (AD) with variable presentations and rates of progression are well known. These subtypes may have specific patterns of regional brain atrophy, which are identifiable on MRI scans. Methods: To examine distinct regions which had distinct underlying patterns of cortical atrophy, factor analytic techniques applied to structural MRI volumetric data from cognitively normal (CN) (n = 202), amnestic mild cognitive impairment (aMCI) (n = 333) or mild AD (n = 146) subjects, in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database was applied. This revealed the existence of two neocortical (NeoC-1 and NeoC-2), and a limbic cluster of atrophic brain regions. The frequency and clinical correlates of these regional patterns of atrophy were evaluated among the three diagnostic groups, and the rates of progression from aMCI to AD, over 24 months were evaluated. Results: Discernable patterns of regional atrophy were observed in about 29% of CN, 55% of aMCI and 83% of AD subjects. Heterogeneity in clinical presentation and APOE ε4 frequency were associated with regional patterns of atrophy on MRI scans. The most rapid progression rates to dementia among aMCI subjects (n = 224), over a 24-month period, were in those with NeoC-1 regional impairment (68.2%), followed by the Limbic regional impairment (48.8%). The same pattern of results was observed when only aMCI amyloid positive subjects were examined. Conclusions: The neuroimaging results closely parallel findings described recently among AD patients with the hippocampal sparing and limbic subtypes of AD neuropathology at autopsy. We conclude that NeoC-1, Limbic and other patterns of MRI atrophy may be useful markers for predicting the rate of progression of aMCI to AD and could have utility selecting individuals at higher risk for progression in clinical trials.

关键词： Subtypes Mild Cognitive Impairment MCI preMCI Amnestic MCI Alzheimer’s Disease Dementia MRI Hippocampal Volume Algorithmic Diagnosis Clinical Diagnosis neuropsychological Tests Longitudinal Analysis Regional Atrophy

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The Relationships between Cognitive neuropsychological State, Oxidative Stress and Genotoxicity in Radiology Staff

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Health 2014年第12期6卷 1376-1384页

作者： Hajar Akbari Dastjerdi Mohammad Fazilati Ali Akbar Malekirad Habibollah Nazem Mohammad Abdollahi Akbar Zerratpisheh Department of Biology Payame Noor University Tehran Iran Faculty of Pharmacy and Pharmaceutical Sciences Research Center Tehran University of Medical Science (TUMS) Tehran Iran Islamic Azad University Jiroft Branch Jiroft Iran

Imbalance between the production and removal of reactive oxygen species (ROS) has been used for characterizing Oxidative stress. Extra amount of ROS are hazardous and can lead damages to the cells resulting in harsh diseases. For cancer, diabetes, psychological disorders and age-related disorders, latent of ROS in induction of alteration and DNA harm is a critical factor. Regarding these finding, the current research was planned to test the relationship between cognitive neuropsychological state and oxidative markers and genotoxicity in radiology staff. Total Number of 47 radiology staff, working in the radiology center of a referral University Hospital in Shiraz, were invited in the study. The participants were occupationally exposed to low-dose ionizing radiation (x-ray) for more than 2 years. Psychological disorder was analyzed by SCL-90-R. In the plasma, lipid peroxidation, DNA harm, catalase, superoxide dismutase, myeloperoxidase, and glutathione peroxidase activity were calculated. Associations between parameters were measured by using Pearson correlation coefficient and multivariate linear regression analyses. As a result, there was a positive considerable connection between catalase and paranoid ideation, Obsessive-Compulsive, Anxiety and total. Furthermore, the correlation between psychoticism, Interpersonal Sensitivity, Paranoid Ideation and DNA damage was positive. There were positive relationships between superoxide dismutase and psychomotor speed, initiative/energy, selective attention and verbal memory. So, there were significant relationships among interpersonal sensitivity, somatization, depression and gender. But, there were no major relationships among psychological distress, history workers and oxidative stress. In so many words, Oxidative stress and genotoxicity result in psychological disorders in radiology staff. So, radiology staff should have more attention, as they suffered from some psychological disorders.

关键词： Poisoning Ionizing Radiation Cognitive neuropsychological Stress Oxidative Stress

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