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Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords

Progress in Natural Science:Materials International 2009年第10期19卷 1261-1269页

作者： Zhigong Wanga,,Xiaosong Gub,Xiaoying Lü c,Zhenglin Jiangb,Wenyuan Li a,Guangming Lü b,Yufeng Wang a,Xiaoyan Shen a,Xintai Zhao a,Huiling Wangc,Zhenyu Zhang a,Hongmei Shen b,Yang Wua,Weixing Shen b,Jingyang Zhang a,Dong Chenc,Xiaoyi Maoa,Huaxiang Shenb a Institute of RF-& OE-ICs,Southeast University,Nanjing 210096,China b Key Laboratory of neural Regeneration of Jiangsu Province,Nantong University,Nantong 226001,China c State Key Laboratory of Bioelectronics,Southeast University,Nanjing 210096,China Institute of RF- & OE-ICs Southeast University Nanjing 210096 China Key Laboratory of neural Regeneration of Jiangsu Province Nantong University Nantong 226001 China State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 China

Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is *** microelectronic system has been realized in the forms of hybrid and integrated *** integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS *** animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic *** the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been ***,the feasibility of the presented method was demonstrated.

关键词： Nerve injury Microelectrode arrays neural recordings Neurostimulation Functional recovery

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